Glycated Hemoglobin Index Research Articles

Glycated haemoglobin index is a new predictor for all-cause mortality and cardiovascular mortality in the adults

Glycosylated haemoglobin index (HGI) has been shown to correlate with the prognosis of metabolic diseases, but the relationship with mortality remains unclear. This study included 18,285 US adults who participated in the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2018. During the median follow-up period of 115 months, a total of 2572 all-cause deaths and 671 cardiovascular disease (CVD) deaths occurred. The restricted cubic spline revealed a U-shaped correlation between HGI and all-cause and CVD mortality. After adjusting for all covariates, the optimal inflection point values in all-cause and CVD deaths were 0.17 and 0.02, respectively. In the left side of the inflection point, the risk of all-cause mortality and CVD mortality decreased by approximately 24% (HR 0.76, 95% CI 0.69, 0.84) and 25% (HR 0.75, 95% CI 0.60, 0.96) with the increase in HGI. Conversely, in the right of the inflection point, an increase of 1 unit in the HGI was linked with a 17% (HR 1.17, 95% CI 1.07, 1.27) and 31% (HR 1.31, 95% CI 1.15, 1.49) increase in all-cause and CVD mortality. Our study showed that HGI is an important tool for predicting the risk of all-cause mortality and CVD death in US adults and there is a U-shaped relationship between HGI and mortality.

Association between glycated hemoglobin index and triglycerides-glucose index in a sample of non-diabetic individuals and its relation with insulin resistance

Introduction: Studies have shown that elevations of the triglyceride/glucose index (TyG) as well as the glycation of hemoglobin index (HGI) are associated with several complications related to insulin resistance (IR). Objective: To evaluate the association between HGI and TyG index in a sample of non-diabetic individuals and it’s relation with IR. Method: A cross-sectional study was conducted with 32 non-diabetic individuals. The variables analyzed included age, gender, body mass index, and laboratory data (triglycerides, glucose, HbA1c, and insulin). We calculated the TyG index, HOMA-IR, and HGI. Simple and multivariate linear regression analyses were also performed, in addition to ANOVA and Pearson's correlation between variables. Results: The multivariate linear regression analysis of the analyzed sample revealed a significant correlation between the TyG index and HGI, which was confirmed by the T-test. The results indicated a strong positive correlation between the TyG index and HGI, with a Pearson correlation coefficient of 0.98. Conclusion: The HGI, TyG index and IR showed a significant association in the analyzed sample. This suggests that both indices are highly reliable in measuring IR and glucose metabolism and may be markers of risk independent of fasting plasma glucose, and the other variables evaluated in this study.

Index-based assessment of type I diabetes mellitus compensation level influence on oral health condition in adolescents

Relevance. Type I diabetes mellitus is generally recognized as a socially significant disease which directly affects the nature and severity of clinical symptoms of comorbidities, including in the oral cavit y.Material and methods. The study, which was conducted in the Department of Pediatrics of the “V.A. Almazov National Medical Research Center” in St. Petersburg, included 54 patients with type I diabetes mellitus. The mean age of the study group was 15.4 ± 1.27 years. Diabetes duration was 71.2 ± 46 months. The average value of glycated hemoglobin is 8.64 ± 1.69. 11% of patients appeared to have uncontrolled hyperglycemia (HbA1c > 7%). The dental examination included a questionnaire, examination and index evaluation using the Green-Vermillion Hygiene Index (OHI), the PMA index modified by Parma, Russell’s periodontal index (PI) and the DMF index. Statistical data was processed using the JAMOVI 2.3.13 software.Results. The principal component analysis distributed the studied indices by three independent mathematical models-constructs. The binomial regression of the OHI and glycated hemoglobin showed a specificity of 0.903 and a sensitivity of 0.348. Regression analysis of the PI and Hb1Ac showed a specificity of 0.919 and a sensitivity of 0.294.Conclusion. The binomial regression model of dental indices with the glycated hemoglobin index values helped to formulate the Hb1Ac key-point values, which allows for suspecting a highly likely initial stage of gingivitis. Hb1Ac above 8.6 is this value.

Fluorescence/electrochemiluminescence approach for instant detection of glycated hemoglobin index

The percentage of glycated hemoglobin (HbA1c) in total hemoglobin (Hb) is an important index for the diagnosis of Type II diabetes (T2D) because it reflects the long-term glucose level in blood. Herein, employing a one-pot co-reduction approach using glutathione (GSH) as structure-directing agent, a cluster-like AuAg nanoparticle (AuAg NPs) material was synthesized, therefore an electrochemiluminescence (ECL) aptamer-sensor for HbA1c detection was developed based on functionalized electrode with this material. Meanwhile, the quantitative determination of total Hb was realized based on the quenching effect of Hb on the fluorescence (FL) of luminol. Under compatible conditions, the results of both indexes can be satisfactorily acquired. This multimodal detection system has a good linear response toward Hb from 0.1 to 2.5 μM and HbA1c from 0.005 to 0.5 μM. The blood test proves this strategy is capable of accurate Hb and HbA1c detection, thus to obtain the percentage of HbA1c in total Hb (HbA1c%), which has the potential application for clinical diagnosis of diabetes mellitus.

Association between dental visits at primary care and glycated hemoglobin level in patients with type 2 diabetes: a cohort study.

To evaluate the association between dental visits and variation in the glycated hemoglobin index (A1C) of patients with type 2 diabetes (T2DM) with well or not well glycemic control over time. Patients with T2DM, A1C ≥ 7% (not well-controlled) and < 7% (well-controlled), who attended a primary care service and were followed up from January 2010 to May 2018. The outcome was the variation of A1C obtained from reference laboratories. At the beginning of the study, a questionnaire with behavioral, clinical, and socioeconomic information was carried out. Multiple linear regression analyses tested interaction terms of all variables with the initial glycemic level (not well-controlled or well-controlled). The sample consisted of 507 people, 65% women, and 66% individuals 55 to 74 years old, followed on average for 5.4 years. There was an interaction (p = 0.01) between dental visits and initial A1C. Patients not well-controlled with at least one dental visit had an average reduction in A1C of -0.56 percentage point (95%CI -1.06 - -0.56), whereas the well-controlled group who also had at least one dental visit had an increase of 0.34 percentage point (95%CI -0.18 - 0.87). Dental visits were associated with an improvement in A1C of approximately a half-percentage point in patients who had the initial A1C considered as not well-controlled.

Effect of glycated hemoglobin index and mean arterial pressure on acute ischemic stroke prognosis after intravenous thrombolysis with recombinant tissue plasminogen activator: Erratum.

Effect of glycated hemoglobin index and mean arterial pressure on acute ischemic stroke prognosis after intravenous thrombolysis with recombinant tissue plasminogen activator: Erratum.

Effect of glycated hemoglobin index and mean arterial pressure on acute ischemic stroke prognosis after intravenous thrombolysis with recombinant tissue plasminogen activator.

To determine whether glycated hemoglobin and mean arterial pressure (MAP) during thrombolysis are prognostic factors of intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) for acute ischemic stroke (AIS).A total of 125 AIS patients, who received rt-PA intravenous thrombolysis in our hospital, were included into the present study, and divided into good prognosis group and poor prognosis group. Univariate and multivariate logistic regression analyses were used to determine the prognostic factors of AIS treated by rt-PA thrombolysis, Spearman correlation analysis was used to analyze the correlation of the accumulated cigarette consumption in the smoking subgroup and glycated hemoglobin in the diabetic subgroup with the prognosis after intravenous thrombolysis and the symptomatic intracranial hemorrhage (sICH).Univariate analysis revealed that the interval from onset to thrombolysis, baseline National Institutes of Health Stroke Scale (NIHSS) score, MAP during thrombolysis and DRAGON score were prognostic factors. Multivariate logistic regression analysis revealed that baseline NIHSS score and MAP during thrombolysis were independent prognostic factors for rt-PA thrombolysis. Furthermore, the glycated hemoglobin index was positively correlated with the incidence of sICH.The NIHSS score before thrombolysis and MAP during thrombolysis were independent factors for the prognosis of AIS treated by thrombolysis. The higher the glycated hemoglobin index of diabetic patients, the more likely they are to develop sICH, the glycated hemoglobin index was negatively correlated with the prognosis after intravenous thrombolysis. The accumulated cigarette consumption was negatively correlated with the prognosis after intravenous thrombolysis.

Crescimento de crianças diabéticas em controle ambulatorial em hospital universitário

Com o objetivo de estudar o crescimento de pacientes com diabetes mellitus tipo 1 (DM1) acompanhados no Ambulatório da Disciplina de Diabetes do Hospital Universitário Pedro Ernesto - UERJ, foram avaliados, em corte transversal, 34 crianças e adolescentes com média (±DP) de 12±3,7 anos de idade, sendo 19 do sexo masculino. A idade de início do DM1 era de 7,8±4,1 anos e a duração da doença 4,2±3,1 anos. A mediana (variação) da relação altura para idade representada por unidades de desvio-padrão, escore Z, (Z A/I), foi de -0,05 (-1,8 a 1,1). Apenas 8,8% e 20,6% do grupo tiveram Z A/I menores que -1,5 e -1, respectivamente. O Z A/I mostrou-se significativamente diferente entre os subgrupos de &lt;FONT FACE=Symbol&gt;£&lt;/FONT&gt;5 anos (SG1) e de &gt;5 anos de doença (SG2), sendo, respectivamente: 0,26 (-1,47 a 1,10) e -0,77 (-1,88 a 0,73); p=0,03. SG1 e SG2 diferem também na idade de início do DM1 que é maior nos pacientes do SG1, respectivamente: 9,2±3,9 anos e 5,2±3,3 anos; p=0,01 Houve correlação negativa do Z A/I com o tempo de doença no grupo geral (r=-0,47; p&lt;0,01). Quando o grupo foi subdividido por índice de hemoglobina glicada (hemoglobina glicada / máximo valor da normalidade) em controle adequado (&lt;1,33) e não adequado ( &gt; ou = 1,33), observamos diferença do Z A/I entre grupos, respectivamente: 0,29 (-1,69 a 0,85) e -0,43 (-1,88 a 1,10); p=0,02. A mediana do escore Z para peso em relação à idade (Z P/I) foi de 0,04 (-1,64 a 1,53). Apenas dois pacientes tiveram seus índices de massa corporal no percentil 85. Em conclusão, os escores de desvio padrão de altura para idade dos pacientes em controle ambulatorial, com tratamento convencional, mostraram correlação com o tempo de doença, sendo mais comprometidos nos pacientes com maior tempo de doença e controle glicêmico não adequado.