Objective To select and study the regulating immune medicines (bailing capsule and six taste glutinous rehmannia ball) combined with immunosuppressive therapy in systemic lupus erythematosus (SLE),to reduce simple immunosuppressive therapy in the treatment of SLE with high infection rates for exploration.Methods Case selection followed the diagnostic criteria (using American College of Rheumatology [ACR]1997 recommended classification criteria) in patients with SLE,retrospective study from January 1,2008 to December 31,2011 with renal involvement and pulmonary interstitial lesions in 61 patients with SLE (from more than two hospitals to standardize treatment and regular follow-up of patients),design combination of traditional Chinese and western medicine treatment group (31 cases),western medicine group (30 cases).The control group of western medicine used the sugar cortical hormone plus cyclophosphamide,combine with traditional Chinese and western medicine in treating group and control group based on the six taste glutinous rehmannia ball and Corbrin capsules by ESR,before and after the treatment,CRP,C3,C4,24h urine protein,ANA,ds-DNA,blood routine changes were all observed throughout the course of treatment.Results The average infection rate was 31.5% in treatment group,43.7% in the control group,treatment group was lower than that of control group.And the total effective rate of the treatment group (83.8%) was significantly higher than that in control group (73.3%).Conclusions The regulation of the immune medicines (bailing capsule and six taste glutinous rehmannia ball),can reduce the immune inhibitor induced adverse reactions and complications,thus enhance the curative effect,prevent and reduce the infection. Key words: Traditional Chinese and western medicine; Regulation Immune; SLE