In this paper, we study an initial-boundary value problem of three-dimensional (3D) compressible isentropic magneto-micropolar fluid equations with Coulomb force and slip boundary conditions in a bounded simply connected domain, whose boundary has a finite number of two-dimensional connected components. We derive the global existence and uniqueness of classical solutions provided that the initial total energy is suitably small. Our result generalizes the Cauchy problems of compressible Navier–Stokes equations with Coulomb force [S. Liu, X. Xu and J. Zhang, Global well-posedness of strong solutions with large oscillations and vacuum to the compressible Navier–Stokes–Poisson equations subject to large oscillations and non-flat doping profile, J. Differ. Equ. 269 (2020) 8468–8508] and compressible MHD equations [H. Li, X. Xu and J. Zhang, Global classical solutions to 3D compressible magnetohydrodynamic equations with large oscillations and vacuum, SIAM J. Math. Anal. 45 (2013) 1356–1387] to the case of bounded domains although tackling many surface integrals caused by the slip boundary condition are complex. The main ingredient of this paper is to overcome the strong nonlinearity caused by Coulomb force, magnetic field, and rotation effect of micro-particles by applying piecewise-estimate method and delicate analysis based on the effective viscous fluxes involving velocity and micro-rotational velocity.