Commonly, Global Positioning System (GPS)-based precise orbit determination (POD) of a low Earth orbiting (LEO) satellite is conducted by introducing fixed GPS orbits and clock corrections that were derived in a previous independent network solution using ground-based GPS receivers only. There have been a number of studies showing that the integration of LEO GPS observations can be advantageous in global network solutions, particularly when it comes to estimating geodetic parameters, such as the Earth’s center-of-mass. There has been an increase in GPS data available from LEO CubeSats over the past few years, such as from the Spire satellites, which are equipped with dual-frequency GPS receivers. The goal of the present study is to determine how GPS observations collected by specific Spire satellites affect global network solutions when combined with GPS observations from ground stations of the International GNSS Service. To obtain a combined GPS-LEO solution, GPS observations collected from receivers of selected Spire satellites and additional scientific LEOs are used to obtain combined GPS-LEO solutions by performing one joint least-squares adjustment process. Using this method, LEO satellite orbit parameters are determined along with GPS orbit parameters and geodetic parameters, namely GNSS station coordinates, Earth rotation parameters (ERPs), and the Earth’s center-of-mass. The influence of the Spire LEOs is assessed by analyzing different solutions that use GPS observations from different Spire and LEO satellites. Besides comparing the different global network solutions with one another, a comparison to a solution using only terrestrial GPS data is performed as well. As part of the quality assessment of the GPS-LEO solution, quality characteristics are analyzed, which are the geodetic parameters, orbit overlaps at arc boundaries, and formal errors determined for the estimated parameters. The results show that the estimation of the Earth’s center-of-mass coordinates benefits from including GPS-LEO observations. The solution is more improved by integrating GPS-LEO observations from scientific LEOs than from GPS-Spire-included solutions. The analysis reveals that GPS orbits are improved using the LEO-integrated approach, while orbit misclosures of LEO and Spire trajectories currently indicate a decrease in LEO orbit precision due to LEO orbit modeling deficiencies.