AbstractEventhough the composition control of chemical reactors is an old, widely studied, and still relevant problem in chemical process control, it still presents some aspects that remain unexplored or unresolved. For instance, a unifying approach is needed to systematize the existing ad hoc controller constructions, to rigorously explain their remarkable robustness property, and to explore the possibility of improving their construction and functioning. In this paper, some aspects of these control problems are addressed by resorting to recently developed approaches in constructive non‐linear control, yielding a systematic controller construction coupled to a simple tuning scheme that can be executed with standard tuning rules, a closed‐loop stability criterion, and an explanation of the closed‐loop dynamics behaviour. Specifically, a linear cascade (master/slave) control configuration is proposed, which leads to global internal stability of the controlled system with asymptotic regulation of the output‐stream composition about a given desired setpoint. A simulation example is used to illustrate the results. Copyright © 2002 John Wiley & Sons, Ltd.