Recent advancements in geospatial technologies have significantly expanded the volume and diversity of geospatial data, unlocking new and innovative applications that require novel Geographic Information Systems (GIS). (Discrete) Global Grid Systems (DGGSs) have emerged as a promising solution to further enhance modern geospatial capabilities. Current DGGSs employ a simple, low-resolution polyhedral approximation of the Earth for efficient operations, but require a projection between the Earth’s surface and the polyhedral faces. Equal-area DGGSs are desirable for their low distortion, but they fall short of this promise due to the inefficiency of equal-area projections. On the other hand, efficiency-first DGGSs need to better address distortion. We introduce a novel mesh-based DGGS (MBD) which generalizes efficient operations over watertight triangular meshes with spherical topology. Unlike traditional approaches that rely on Platonic or Catalan solids, our mesh-based method leverages high-resolution spherical meshes to offer greater flexibility and accuracy. MBD allows high-resolution polyhedra (HRP) to be used as the base polyhedron of a DGGS, significantly reducing distortion. To address the operational challenges, we introduce a new hash encoding method and an efficient barycentric indexing method (BIM). MBD extends Atlas of Connectivity Maps to the BIM to provide efficient spatial and hierarchical traversal. We introduce several new base polyhedra with lower areal and angular distortion, and we experimentally validate their properties and demonstrate their efficiency. Our experimentation shows that we achieve constant-time operations for high-resolution MBD, and we recommend polyhedra to be used as the base polyhedron for low-distortion DGGSs, compact faces, and efficient operations.