This study aimed to evaluate the flexural strength (FS) and surface roughness (Ra) of heat-polymerized poly methyl methacrylate (PMMA) acrylic resin reinforced with glass fibers (GF) and polypropylene fibers (PPF) in different concentrations. One hundred heat-cured PMMA resin samples were prepared and randomly allocated into five groups based on fiber reinforcement (n = 20). Group 1 had no fiber reinforcement, Group 2 had 0.5% silanized GF reinforcement, Group 3 had 1% silanized GF reinforcement, Group 4 had 0.5% silanized PPF reinforcement, and Group 5 had 1% silanized PPF reinforcement. Fatigue load was applied through artificial aging. FS testing of fifty samples was performed using a universal testing machine, and Ra was analyzed using an optical interferometric profilometer. Specimens were selected for SEM and EDX analysis. To find the differences among the studied groups, one-way analysis of variance and post hoc Tukey’s test were utilized. The results showed that Group 5 (1% PPF reinforcement) presented the highest fracture resistance (90.1±9.8 MPa), while the minimum FS scores were observed in Group 1 (no reinforcement) (59.2±7.1 MPa). Group 3 (1% GF reinforcement) exhibited the highest values of surface roughness (1.99±0.1992), whereas the lowest roughness scores were observed in Group 1. The study concluded that incorporating 0.5% PPF into the resin denture is a viable option for reinforcing the prosthesis without increasing surface roughness.