The performance of both the tectonic uplift and of the 4th-order glacial eustatic sea level fluctuations in controlling the stratigraphic architecture of Quaternary lowstand prograding wedges of the Salento continental shelf (Southern Adriatic sea, Italy) during a time interval spanning from the Middle Pleistocene to the Holocene has been pointed out through the interpretation of high-resolution seismic reflection profiles and their correlation to the curves of the isotopic stratigraphy. Three main transgressive surfaces of erosion (RS1, RS2 and RS3) punctuate the stratigraphic architecture of the Salento continental shelf, separating Quaternary lowstand prograding wedges between them. All along the Middle Pleistocene, increasing the tectonic uplift of the Puglia offshore, combining with 4th-order glacio-eustatic variations, have dealt with the pattern of a broad forced regression prograding wedge, favoring a platform progradation of approximately 15 km. The architectural stacking patterns of the overlying Late Pleistocene and Holocene prograding wedges are controlled by 4th-order glacio-eustatic sea level changes, allowing for the formation of incomplete depositional sequences. In this period, the eustatic signature overcomes the tectonic mark, implying a decline in the uplift of the Apulian foreland in the course of the final 250 ky.
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