The Zheduo–Gongga Mountain, an enormous tower located at the boundary of the eastern Tibetan Plateau, is an ideal place to study the contribution of the climate and/or tectonics to the mountain building. Here, we report new zircon U–Pb ages, biotite 40Ar–39Ar, and apatite fission track (AFT) ages of granites along the Zhonggu transect in the northern part of the Zheduo–Gongga massif to investigate the detailed exhumation history and mechanism. The results show zircon U-Pb ages of 14.3 ± 0.3 and 11.3 ± 0.2 Ma, Biotite 40Ar–39Ar ages of 4.39 ± 0.07 and 3.62 ± 0.05 Ma, and AFT ages of ~2.6–0.9 Ma. Combining previous structural and geochronological studies, we argue that the growth and exhumation of the Zheduo–Gongga Mountain experienced the following stages. Late Oligocene–early Miocene crust shortening and magmatism marked the initiation of the crustal thickening and surface uplift during ~32–11 Ma, forming a migmatite–granitic belt along the Xianhuihe fault, in response to the northward advancing of the Indian plate into the Eurasian plates. Subsequently, the massif experienced episodic phases of exhumation with variable rates. The exhumation occurred at a rate of ~1–1.5 km/Ma with a cooling rate of 70 ± 20 °C/m.y. during ~11–5 Ma coinciding with the coeval intensification of the Asian monsoon and clockwise rotation of the Chuandian block, south of the Xianshuihe fault. During ~5–2 Ma, a phase of accelerated exhumation (~2–5 km/Ma) started, followed by a possible phase of decelerated exhumation (~1–1.5 km/Ma, corresponding to a cooling rate of 120 ± 20 °C/m.y.) since ~2 Ma, when alpine glaciations initiated due to global cooling. This study highlights the importance of tectonic deformation during ~11–5 Ma in controlling the early growth and exhumation of high mountains in the eastern Tibetan Plateau. The climate may account for the later exhumation of the Zheduo–Gongga mountain since ~5 Ma.