Global self-esteem and Emotional Regulation contribute to the well-being, social adaptation and comprehensive development of people, both of which are scarcely studied in Gifted students, especifically in the Chilean and Latin American context, hence their importance. This study seeks to identify the level of global self-esteem, recognize the emotional regulation strategy used and the relationship between global self-esteem and emotional regulation strategies in 37 Gifted students participants in a Chilean extracurricular enrichment program. To this effect, the Piers-Harris Self-Concept Scale for children and young people, in Gorostegui's version, and the Emotional Regulation Questionnaire for children and adolescents (ERQ-CA), version revised by Gullone and Taffe (2012) are used. A descriptive analysis and a correlation analysis of variables are carried out, revealing that these students have adequate levels of global self-esteem, mostly use cognitive reassessment as an emotional regulation strategy, and there is a statistically significant negative correlation between global self-esteem and expressive suppression. This study becomes a contribution to the knowledge of socio-affective qualities of Gifted students and highlights the relevance of creating educational spaces focused on the satisfaction of their needs in a comprehensive and systematic manner.