Mesenteric cysts are a rare occurrence in clinical practice, and even fewer are found to be of Mullerian origin. Diagnosis of mesenteric cysts is typically based on clinical assessment and radiological imaging. Surgical excision remains the primary treatment option. We report a case of a middle-aged lady presenting with a giant mesenteric cyst weighing 8-kilogrammes that was managed with laparotomy. Current literature of this rare clinical entity was also reviewed, including differential diagnoses of cystic lesions within the abdomen and role of imaging in guiding pre-operative diagnosis and management strategies. The giant mesenteric cyst was successfully excised en bloc without spillage via a laparotomy. Analgesia optimisation was achieved with a continuous local anaesthetic infusion. Pre-operative radiology can assist in diagnosis of the mesenteric cyst and guide management. Should an open surgical approach be selected, analgesia can be optimised with a continuous local anaesthetic infusion which decreases need for opioid medications.