This research paper, which is part of a broader study, seeks to contribute to knowledge on the Resource Description and Access standard by exploring the state of readiness of Ghanaian university libraries to implement the standard, as well as highlighting the myriad of activities and initiatives that libraries should undertake in preparation for RDA implementation. This convergent parallel mixed methods study engaged 62 cataloguing practitioners, across nine university libraries, through questionnaires and interviews as data collection instruments. The analysis of data revealed the importance of planning and an overwhelming state of unpreparedness among Ghanaian university libraries to implement the standard. The study also contributes various appropriate activities and initiatives for readying libraries for RDA implementation to RDA literature. It is recommended among others, that university library management and leaders of professional library organisations designate RDA preparatory periods and forge collaborations and partnerships with libraries that have implemented the RDA standard.