This article is devoted to studying multiplicity and regularity of analytic sets. We present an equivalence for analytic sets, named blow-spherical equivalence, which generalizes differential equivalence and subanalytic bi-Lipschitz equivalence and, with this approach, we obtain several applications on analytic sets. On multiplicity, we present a generalization for Gau–Lipman’s Theorem about differential invariance of the multiplicity in the complex and real cases, and we show that the multiplicity \(\mathrm{mod}\,2\) is invariant under blow-spherical homeomorphisms in the case of real analytic curves and surfaces and also for a class of real analytic foliations and is invariant by (image) arc-analytic blow-spherical homeomorphisms in the case of real analytic hypersurfaces, generalizing some results proved by G. Valette. On regularity, we show that blow-spherical regularity of real analytic sets implies \(C^1\) smoothness only in the case of real analytic curves. We present also a complete classification of the germs of real analytic curves.