Georges Pompidou Research Articles

Real-world evaluation of nivolumab utilization in adjuvant treatment of localized muscle-invasive urothelial carcinoma

IntroductionIn 2022, nivolumab was granted marketing authorization for adjuvant treatment in patients at high-risk of recurrence following surgery for localized invasive muscle urothelial carcinoma, who express PD-L1 on the operative specimen. We aimed to investigate its real-world utilization. Materials and methodsOur bicentric real-world study, conducted at Foch Hospital and Georges-Pompidou European Hospital between July 2022 and January 2024, included patients who underwent surgery for urothelial carcinoma or were referred for adjuvant nivolumab treatment at these centers. ResultsA total of 200 patients underwent surgery during the study period, of whom 70 met the high-risk criteria, with 46% of these patients not receiving adjuvant treatment due to ineligibility. Our survival outcomes among patients treated by nivolumab are consistent with the results of the CheckMate 274 study (Bajorin et al. N Engl J Med. 2021). Our study population was older and frailer than that of the study cohort, with a mean age of 69years. Significant PD-L1 expression was observed in 66% of the tested patients. The median disease-free survival was 11.34months in patients who received neoadjuvant chemotherapy followed by surgery and adjuvant nivolumab. Nivolumab was generally well-tolerated, but 25% of patients discontinued it due to toxicity. Our initial data on treatments for recurrence after adjuvant nivolumab highlighted the effectiveness of conventional chemotherapy (cisplatin or carboplatin combined with gemcitabine) and targeted chemotherapy (enfortumab vedotin). ConclusionOur real-world data align with existing literature regarding adjuvant nivolumab in localized invasive muscle urothelial carcinoma. Level of evidence3.

ЕВРОПЕЙСКАЯ ИДЕЯ ШАРЛЯ ДЕ ГОЛЛЯ И ЖОРЖА ПОМПИДУ

В статье представлены концепции «объединенной Европы», выдвинутые двумя первыми президентами Пятой республики во Франции Шарлем де Голлем и Жоржем Помпиду. На основе высказываний самих глав французского государства рассмотрены их предложения по устройству и развитию Европейского экономического сообщества и воплощение идей двух политиков в жизнь. The article presents the concepts of “united Europe” put forward by the first two presidents of the Fifth Republic in France, Charles de Gaulle and Georges Pompidou. On the basis of the statements of the heads of state, their proposals for the structure and development of the European Economic Community and the implementation of their ideas were considered.

Chaosmosis: Ethical, Artistic, Political Stakes

Abstract: This essay introduces the concept of "Chaosmosis," as employed by Jean-Jacques Lebel for the collective exhibition of the same name at the Centre Georges Pompidou in Paris in 2024. Considering the intellectual origins of the term, from the writings of James Joyce, Umberto Eco, and Félix Guattari, as well as Lebel’s close friendship with Guattari, it explains how "chaosmos" offers an ethico-aesthetic paradigm with which to conceive of and continue the surrealist revolution.

Treatment of Aortoiliac Occlusive Lesions by Aortic Robotic Surgery: Learning Curve and Midterm Outcome

The learning curve and midterm results of aortoiliac occlusive disease (AIOD) revascularization by robot-assisted laparoscopic (RAL) surgery may be known. A prospective single-center study was conducted in the vascular surgery department of Georges Pompidou European Hospital (Paris, France). Patients with AIOD treated by RAL from February 2014 to February 2019 were included. Demographic characteristics, past medical history, Trans-Atlantic Inter-Society Consensus (TASC) lesions classifications, mortality, primary and secondary patency, as well as complication rates were collected. Safety was analyzed by the cumulative sum control chart method with a conversion rate of 10%, operative time by cumulative average-time model, and primary and secondary patency by the Kaplan-Meier method. Seventy patients were included, 18 (25.7%) with TASC C lesions and 52 (74.3%) with TASC D lesions. Before discharge, 14 (24.3%) patients had surgical complications. Among them, 10 (14.3%) required at least one reintervention. One (1.4%) patient died during the hospitalization. The learning curve in terms of safety (conversion rate) was 13 cases with an operating time of 220minutes after 35 patients. During follow-up (median 37months [21; 49]), 63 patients (91.3%) improved their symptoms, 53 (76.8%) became asymptomatic, and 3 graft limb occlusions occurred. The primary patency at 12, 24, 36, and 48months was 94%, 92%, 92%, and 92%, respectively, while the secondary patency for the same intervals was 100%, 98.1%, 98.1%, and 98.1%, respectively. Robotic surgery in AIOD revascularization seems safe and effective; allowing to treat patients with few comorbidities and severe lesions, in a dedicated center experienced in RAL, with excellent patency. Prospective clinical trials should be performed to confirm safety.

Updates in BRAF V600E-Mutated Metastatic Colorectal Cancer

Colorectal cancer (CRC) is the third most common cancer worldwide, and the second leading cause of cancer death. Approximately one in five patients with CRC present with metastatic disease at diagnosis. The BRAF V600E mutation occurs in 8–12% of patients with metastatic colorectal cancer (mCRC), and is characterised by an aggressive clinical course and poor prognosis. This article is based on a webinar discussion in March 2024, between two experts in gastrointestinal cancers, Chiara Cremolini, University of Pisa, Italy; and Julien Taieb, Georges Pompidou European Hospital, Université Paris-Cité, France, both of whom have a wealth of experience and expertise in the clinical management of CRC. The experts described the most important recent advances in the treatment of BRAF V600E-mutated mCRC, including data presented at the European Society for Medical Oncology (ESMO) Congress in October 2023, and the American Society of Clinical Oncology (ASCO) Gastrointestinal (GI) Cancers Symposium in January 2024. Cremolini and Taieb gave valuable insights into topics such as the aggressive nature of BRAF V600E-mutated mCRC, and how this impacts choice of treatment, patient outcomes, and quality of life, as well as the importance of early testing and monitoring. The experts also discussed how the BRAF V600E mutation impacts treatment response and outcomes in patients with microsatellite unstable (microsatellite instability [MSI]) versus microsatellite stable (MSS) tumours, and recent key clinical trials in BRAF V600E-mutated mCRC. The importance of surgery in the multidisciplinary management of patients with BRAF V600E-mutated mCRC, BRAF as a prognostic marker in resected CRC, and real-world studies in this field were also explored. Finally, Cremolini and Taieb described what the future of the management of patients with BRAF V600E-mutated mCRC might look like, and which advancements in research they would like to see.

From ritual to performance: Ta'zieh in Iran today

Abstract As a practice and experience, ta'zieh lies at the crossroads between ritual and performance, collective lament and recollection, literature, and folklore. Focusing on the experience of the spectator, this paper discusses ta'zieh's liminal status and diverse functions in Iran today. This study is based on observations gathered during fieldwork in the fall of 2017 in Tehran (Grand Bazaar), Isfahan (Falāvarjān), and Kashan (Nushābād). By way of comparison, we further reflect on a video installation by Abbas Kiarostami presented at the Centre Georges Pompidou in Paris in 2003, which challenges common assumptions about the aesthetic and religious effectiveness of ta'zieh. The contrast allows us to elucidate how, by renovating ancient narrative forms, contemporary Iranian performing arts partake in the shaping of individual affects as well as communal emotions.

Patterns of recurrence in surgically treated women for TP53-mutated endometrial carcinomas

ObjectiveTo describe the patterns of recurrence and the prognosis of patients with a recurrent TP53 mutated endometrial carcinoma treated initially by surgery. MethodsAll patients with endometrial carcinoma, treated at hospital European Georges Pompidou between 2001 and 2021 were retrospectively included. Patients were separated into two groups: TP53-mutated and not TP53-mutated (POLE/ultramutated-like (POLEmut), dMMR (mismatch repair-deficient) and NSMP (No specific molecular profile)). We estimated survival using recurrence free survival, overall survival and overall survival from recurrence. The risk of recurrence according to TP53 status and the type of recurrence (locoregional recurrence, peritoneal recurrence, and metastasis) were also compared between the two groups. ResultsTwo hundred and ninety-one patients with endometrial carcinoma were included. Of these, 57 were TP53-mutated and 234 patients were not TP53-mutated. TP53 mutated patients had the worst recurrence free survival and overall survival (p < 0.001 for each). The hazard rate of recurrence was higher during the first three years for TP53 mutated endometrial carcinoma then tend to join the one of no TP53 mutated. There was a statistical difference between the two groups in terms of cumulative incidence of peritoneal recurrence (p = 0.002). There was, however, no statistical difference in overall survival from recurrence. ConclusionsTP53-mutated endometrial carcinoma were more likely to experience a recurrence during the first three years and most often peritoneal recurrence compared to not TP53-mutated. TP53 status in endometrial carcinoma could be useful to define follow-up. Further prospective studies are required to assess the predictive impact of TP53 mutation on chemotherapy benefit.

TRANSLUMINAL ANGIOPLASTY OF THE RENAL ARTERIES IN PATIENTS WITH FIBROMUSCULAR DYSPLASIA

Objective: FMD is the second most frequent cause of renal artery stenosis (RAS) after atherosclerosis and can lead to hypertension. To cure or improve this renovascular hypertension, patient with fibromuscular dysplasia and renal artery stenosis undergo renal artery revascularization by percutaneous renal transluminal angioplasty (PTRA). Although this method has been performed for many years, there have been only few small size trials published. This retrospective single center study aimed to evaluate the rate of cured hypertension after PTRA. Design and method: We included all adult patients diagnosed with FMD who were seen in our referral center for hypertension management (Hôpital Européen Georges Pompidou, Paris) from January 2010 to March 2020. Blood pressure response was assessed at 3 month and one year. Primary outcome was one year cured hypertension rate in ambulatory measurement, secondary outcomes were improvement and complication rate. Results: Overall, 76 adult patients (87% female, mean age at enrollment 35.5 years) were included. FDM was multifocal in 74% and unisite in 68% of patients. AT baseline, mean day ambulatory blood pressure (dABP) was 141 ± 17/89 ± 14 mmHg under a mean of 2.3 ± 1.37 antihypertensive treatments. All patient underwent PTRA. Stent were inserted in 8 patients (10.5%) with residual stenosis after PTRA and in 8 patients (10.5%) with renal artery dissection, total complication rate was 18.4%. At one-year follow-up, mean dABP was 128 ± 12/78 ± 9 mmHg (p &lt; 0.0001) with 1.1 ± 1.3 treatments (p &lt; 0.0001). In total, 75% beneficiated from renal angioplasty: 31% were cured and 44% were improved. Cured hypertension was associated with low body mass index (BMI) (p = 0.017) and unisite FDM (p = 0.017) on a multivariable analysis. Conclusions: In patients with FMD, PTRA is associated with cured hypertension 31% of patients with renal artery FMD undergoing PRTA. Hypertension is more likely to be cured in patient with low BMI and multisite FMD. These results are to be put in perspective with a complication rate of 18.4%.

Équivoques de l'oubli après Vichy

Abstract Through a reflection on the ambiguous facets of Holocaust oblivion that has lasted for generations, the article examines how the official politics of memory in France instrumentalized historical oblivion as an ideological tool. To this end, the essay analyzes Fabrice Humbert's 2009 novel, L'Origine de la violence, to examine the essential role of literature in pinpointing the dynamics of memory and forgetting while exploring the ambiguity of oblivion, pardon and reparation. The unveiled family secret is explored as an allegory of the cryptic national history that reflects the amnesia imposed after the Vichy regime (1940-1944) by the “resistancialisme” promulgated in the post-war period in France; amnesia decreed years later by President Georges Pompidou when he pardoned the French war criminal Paul Touvier in 1972. This politics of forgetting comforted a generation of citizens implicated in collaboration during WWII, resulting in conflicts with the younger generations, as portrayed in Humbert's text.

A Museum of Black Civilizations in the Contemporary World: In conversation with Hamady Bocoum

A Museum of Black Civilizations in the Contemporary World: In conversation with Hamady Bocoum

Clinical outcomes of adapted hypofractionated radiotherapy for bladder cancer in elderly patients.

To investigate the feasibility, efficacy, and safety of trimodal therapy (TMT) using a bifractionated split-course hypofractionated radiotherapy (RT) for non-metastatic muscle-invasive bladder cancer (MIBC) in elderly patients. We retrospectively reviewed the characteristics and outcomes of patients aged >75 years with non-metastatic MIBC suitable or not for radical cystectomy (RC) and treated with transurethral resection of bladder tumour followed by concomitant radio-chemotherapy (platinum salt and 5-fluorouracil) at two institutions (Saint Louis Hospital, Paris, France and European Georges Pompidou Hospital, Paris, France) between 1990 and 2021. RT consisted of an adapted bifractionated split-course hypofractionated RT. Acute toxicities were reported according to Common Terminology Criteria for Adverse Events version 5.0 and late toxicities were reported according to the Radiation Therapy Oncology Group/European Organisation for Research and Treatment of Cancer late radiation morbidity scoring schema. The primary end-point was overall survival (OS). Secondary end-points included other survivals outcomes and safety. A total of 122 patients were identified, with a median (range) follow-up of 51.1(0.5-210.8)months. In all, 83.5% of patients completed radio-chemotherapy. The OS rate was 61.7% at 3 years and 51.2% at 5 years. In multivariate analysis, the completion of RT and concomitant chemotherapy were significantly associated with better OS and cancer-specific survival. For patients fit for RC, a complete histological response was achieved for 77 patients (91.7%) with radio-chemotherapy and the bladder conservation rate was 90.5%. Acute and late Grade ≥3 toxicities were <5%. Bifractionated split-course hypofractionated RT with concomitant chemotherapy regimen appears to be well-tolerated and effective. Trimodal treatment seems to be a curative option for elderly patients unfit for radical surgery compared with palliative care and may contribute to improved survival in these patients.

Circulation Global Rounds: France

HomeCirculationVol. 147, No. 5Circulation Global Rounds: France No AccessArticle CommentaryRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessArticle CommentaryRequest AccessFull TextCirculation Global Rounds: France Nicolas Danchin, MD, PhD and Claire Bouleti, MD, PhD Nicolas DanchinNicolas Danchin Correspondence to: Nicolas Danchin, MD, PhD, Department of Cardiology, Hôpital Européen Georges Pompidou, 20 Rue Leblanc, 75015 Paris, France. Email E-mail Address: [email protected] https://orcid.org/0000-0001-9263-5051 Université de Paris Cité, Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, France (N.D.). Search for more papers by this author and Claire BouletiClaire Bouleti https://orcid.org/0000-0001-6922-0093 Hôpital Paris St Joseph, France (N.D.). University of Poitiers, Clinical Investigation Center (INSERM 1204), Cardiology Department, Poitiers Hospital, France (C.B.). Search for more papers by this author Originally published30 Jan 2023https://doi.org/10.1161/CIRCULATIONAHA.122.059479Circulation. 2023;147:361–363FootnotesFor Sources of Funding and Disclosures, see page 363.Circulation is available at www.ahajournals.org/journal/circCorrespondence to: Nicolas Danchin, MD, PhD, Department of Cardiology, Hôpital Européen Georges Pompidou, 20 Rue Leblanc, 75015 Paris, France. Email nicolas.danchin.[email protected]com

Systematic search for the UBA1 mutation in men after a first episode of venous thromboembolism: A monocentric study

Systematic search for the UBA1 mutation in men after a first episode of venous thromboembolism: A monocentric study

Long-term continuous flow ventricular assist in children and adult congenital patients (HeartWare and HeartMate): Current status in France and feedback

The ACHD patient population has the highest rate of death on the transplant waiting list. Compared to optimal medical therapy, continuous flow LVADs (HeartMate and HeartWare) improve survival, quality of life, allow patients to return home. Among them, the HeartMate 3 (HM3) device has the fewest reported adverse events, and the only one available since 2021. HM3 use is associated with low mortality and few adverse events. Foreign literature reports implantations in children as small as 19 kg, as well as ACHD patients with complex heart disease. Current data on the efficacy and safety of implantation in these patients are favorable. No cases have been reported in France to date. To determine the current state of practice in France regarding long-term continuous left-sided single ventricular assist in children and adult congenital patients. To present the results of two successful French implantations. Between June and July 2022, the different pediatric and adult congenital cardiac surgery centers in France and the manufacturers Abbott (HeartMate) and Medtronic (HeartWare) were contacted. A questionnaire will be sent to surgical centers to understand the low use of this type of assistance in France in 2022. The cases of two patients implanted at the Georges Pompidou European Hospital between 2020 and 2022 will be reported: the case of a 15-year-old patient with dilated cardiomyopathy in the context of Duchenne muscular dystrophy, and the case of a 36-year-old patient with Fontan circulation and systolic dysfunction of his single ventricle. The description will include quality of life indexes, collected by means of a questionnaire under stable conditions. The aim of this study is to identify the reasons for the low use of long-term continuous left single ventricular assistance in the population concerned. The aim will be to promote this practice in this population. The sharing of experiences is essential in such a specialized field. We will propose lines of thought to promote long-term assistance in non-experienced centers.

Eligibility assessment for aortic valve repair in adults congenital patients

Aortic valve (AV) pathology in adult congenital heart disease (ACHD) patients has its own etiologies: bicuspid aortic valve (BAV), conotruncal anomalies, Laubry-Pezzi syndrome, subvalvular aortic membrane, genetic disorders or postoperative lesions (Ross procedure or previous AV repair). Following the example of mitral plasty in the 1980s, surgical techniques for AV repair have been standardized since the 2000s and show very good results in selected patients, allowing a substantial reduction in the risk of prosthesis-related complications. To present an accurate and reproducible transthoracic and transesophageal echo protocol analysing aorta phenotypes and AV and predict the immediate success of AV repair in ACHD patients. The study involved a retrospective analysis of all the ACHD patients operated between January 2018 and May 2022 for AV surgery at the Georges Pompidou European Hospital in Paris. Clinical characteristics, type of ACHD, severity and type of valve involvement (insufficiency, stenosis, or dilatation of the aortic root) were collected. Preoperative and postoperative transthoracic and transesophageal echography were performed using a unique protocol with a 3D approach. Preoperatively, the AV dysfunction, its lesion at the origin and its etiology were defined. Measurements of aortic annulus, effective heights, geometric heights, commissural angle if BAV were made, and the presence of fenestrations, calcifications were noted. In case of AV repair, all measurements were repeated postoperatively. The surgical techniques of aortic plasty were noted. Sixty-three patients were analyzed, 46% of whom were referred for AV repair. Fifty percent of them had BAV, 30% of them were redux of AV repair (20%) or Ross procedure (10%), 20% had conotruncal anomalies. Aortic plasty was performed in 33% of patients, including external ring annuloplasty in case of AV regurgitation with an annulus diameter ≥ 25 mm. We analyzed which patients have the best chance to be reparable. ACHD patients are challenging patients for AV repair. A standardized echo protocol helps to predict the reparability, in order to know if the cardiologist should address his patient in expert surgeons’ hands.

Bladder preservation in older adults with muscle-invasive bladder cancer: A retrospective study with concurrent chemotherapy and twice-daily hypofractionated radiotherapy schedule

IntroductionBladder cancer occurs mainly in older adults and surgery is not always possible when there are geriatric conditions and comorbidities. Trimodal treatment (TMT) combining trans-urethral resection of bladder tumour (TURBT) followed by concurrent chemoradiation (CRT) would be a curative alternative in such patients. Materials and MethodsAll consecutive patients 75 years of age and older with non-metastatic muscle-invasive bladder cancer (MIBC) treated with TMT by Georges Pompidou European Hospital team were retrospectively analysed. Induction CRT combined hypofractionated twice-daily radiotherapy targeting bladder and pelvis to a total dose of 24 Gy (Gy) with concurrent platinum salt and 5-fluorouracil. Consolidation CRT to a total dose of 44 Gy was proposed to patients with biopsy-proven complete response after induction phase and those with persistent tumour underwent salvage cystectomy. We assessed using Kaplan-Meier method overall survival (OS), cancer specific survival (CSS), invasive recurrence-free survival (IRFS), metastasis-free survival (MFS), survival with bladder preserved (SBP), and toxicities. With a Cox model for OS and the Fine Gray method of competing risk for secondary endpoints, we analysed in univariate (u) and multivariate (m) analysis the impact of tumour characteristics and patient profiles: gender, age, age-adjusted Charlson comorbidity index, polypharmacy, and malnutrition. ResultsFrom 1988 to 2017, 85 patients were included. After induction, complete response rate was 83.5%. With a median follow-up of 63 months, 5 year-OS, CSS, IRFS, MFS and SBP were 61.0%, 77.6%, 71%, 82.9%, and 70.2% respectively. A persistent tumour after induction impacted SBP (SHRm 3.61; p = 0.004), CSS (SHRm 3.27; p = 0.023), and MFS (SHRm 3.68; p = 0.018). Late grade 3 urinary and gastrointestinal toxicities were 3.5% and 1.2%. DiscussionWe report here the largest series of bladder preservation over 75 years in a curative intent. Outcomes and tolerance in selected older adults compared favourably with surgical series and with CRT studies using classical fractionation.

Bleeding risk of intramuscular injection of COVID‐19 vaccines in adult patients with therapeutic anticoagulation

Bleeding risk of intramuscular injection of COVID‐19 vaccines in adult patients with therapeutic anticoagulation

Tabagisme du personnel de deux hôpitaux de l’Assistance Publique–Hôpitaux de Paris, 2021

A survey on smoking prevalence was conducted among staff at the Georges Pompidou and Corentin Celton hospitals in the framework of the "smoke-free hospital" project. It aimed to determine the smoking status of different categories of personnel, their desire to be helped to quit and, as regards healthcare staff, whether or not they were encouraging patients who smoked to try to quit. From February to May 2021, an anonymous survey was distributed, first on paper in the occupational health unit, and then online in all wards. All in all, 775 people, three quarters of whom were women, participated in the survey (15% of the workforce). Among the respondents, 27% said they smoked: 29.6% of the men and 26.1% of the women. Unsurprisingly, the age group with the highest prevalence was 18-24years. High prevalence was likewise found among technical and administrative staff. More than half of the smokers, who consumed an average of 8 cigarettes a day, were interested in receiving smoking cessation support. As regards smoking cessation support for patients, 49% of medical and nursing staff (70% of the doctors) frequently or systematically advised them to quit. Our results illustrate a need to reach high-prevalence categories of smokers in a hospital setting, the objective being to help them to consider quitting, and also a need to train health professionals in smoking cessation counseling.

ЛАТИНОАМЕРИКАНСКАЯ ПОЛИТИКА ФРАНЦИИ: ЭВОЛЮЦИЯ В ГОДЫ ПЯТОЙ РЕСПУБЛИКИ

The article examines the evolution of the French foreign policy towards the Latin America in the period of the Fifth Republic. It is noted that this policy was uneven, because it depended on the preferences of each president who plays a major role in determining the country’s foreign policy priorities. Charles de Gaulle, in the framework of his policy of restoring the «greatness» France, attached great importance to political, economic and cultural ties with Latin America and made a very important personal contribution to building up such ties. Georges Pompidou and Valery Giscard d’Estaing did not show much interest towards the region, although they encouraged trade and economic exchanges with it, allowing to sell French goods there, and in return receive row materials and semi-finished products for their own industry. On the contrary, François Mitterrand developed political and cultural relations with the Latin America countries, with the focus on supporting the «progressive» forces and democratization processes. Jacques Chirac and Nicolas Sarkozy took a more pragmatic approach, but they did a lot to develop economic and political co-operation with the region both at the bilateral level and trough the EU. François Holland, who believed that the Latin America had a «great future», promoted the relations with it even more actively. At the same time, protecting the interests of French agricultural producers he practically blocked negotiations between the EU and the common market MERCOSUR on a free trade zone and association. Under Emmanuel Macron Latin America «dropped out» of French policy priorities, which led to the loss of the former dynamics of relations. The coronavirus pandemic has dealt a severe blow to mutual trade and economic exchanges. However, some prospects of enhancing co-operation still exist.

Next-Generation Sequencing Targeted Panel in Routine Care for Metastatic Colon Cancers.

Simple SummaryThe place of Next-Generation-Sequencing (NGS) targeted panel in routine practice in digestive oncology should be addressed. The aim of our retrospective study was to assess the results and impact of NGS panel for metastatic colorectal cancer (mCRC) patients. In total, 210 patients with mCRC were included. Based on our findings, a major advantage of the NGS panel over single gene techniques is that, beyond the classical hotspots, it allows for an exhaustive search for molecular abnormalities in routinely recommended genes. In addition, routine NGS is a way to detect amplifications associated with resistance to anti-EGFR therapies and low-prevalence mutations in actionable genes, providing patients with the opportunity to access innovative targeted therapies. In conclusion, NGS targeted panel in mCRC is feasible in routine practice. Nevertheless, panels need to be regularly updated and in-depth studies are needed to better analyse the prognostic factors.In digestive oncology, the clinical impact of targeted next-generation sequencing (NGS) in routine practice should be addressed. In this work, we studied the impact of a 22-gene NGS amplicon-based panel with Ion Torrent Proton Sequencing, prospectively performed in routine practice. We analyzed the results of extended molecular testing, beyond RAS and BRAF, in metastatic colorectal cancer (mCRC) patients in a single-center, retrospective, observational study of consecutive mCRC patients followed up at the Georges Pompidou European Hospital between January 2016 and December 2018. Overall, 210 patients with mCRC were included. Median follow-up was 25.4 months (IQR: 14.9–39.5). The three most frequently mutated genes were: TP53 (63%), KRAS (41%) and PIK3CA (19%). A positive association was found between overall survival and performance status (PS) ≥ 2 (HR: 4.91 (1.84–13.1); p = 0.001) and differentiation (HR: 4.70 (1.51–14.6); p = 0.007) in multivariate analysis. The NGS panel enabled five patients to access a targeted therapy not currently registered for CRC. In conclusion, targeted NGS panels in mCRC are feasible in routine practice, but need to be regularly updated and in-depth studies are needed to better analyze the prognostic factors.