Geometric Singular Perturbation Research Articles

Bifurcation of the travelling wave solutions in a perturbed (1 + 1)-dimensional dispersive long wave equation via a geometric approach

Choosing ${\kappa }$ (horizontal ordinate of the saddle point associated to the homoclinic orbit) as bifurcation parameter, bifurcations of the travelling wave solutions is studied in a perturbed $(1 + 1)$ -dimensional dispersive long wave equation. The solitary wave solution exists at a suitable wave speed $c$ for the bifurcation parameter ${\kappa }\in \left (0,1-\frac {\sqrt 3}{3}\right )\cup \left (1+\frac {\sqrt 3}{3},2\right )$ , while the kink and anti-kink wave solutions exist at a unique wave speed $c^*=\sqrt {15}/3$ for $\kappa =0$ or $\kappa =2$ . The methods are based on the geometric singular perturbation (GSP, for short) approach, Melnikov method and invariant manifolds theory. Interestingly, not only the explicit analytical expression of the complicated homoclinic Melnikov integral is directly obtained for the perturbed long wave equation, but also the explicit analytical expression of the limit wave speed is directly given. Numerical simulations are utilized to verify our mathematical results.

Geometric Singular Perturbation Analysis to a Perturbed $(1 + 1)$-Dimensional Dispersive Long Wave Equation

The existence of the solitary wave and the nonexistence of kink (anti-kink) wave solutions are studied for a perturbed $(1 + 1)$-dimensional dispersive long wave equation. The methods are based on the geometric singular perturbation {(GSP, for short)} approach, Melnikov method and bifurcation analysis. The results show that the solitary wave solution with a suitable wave speed $c$ and parameter ${\kappa}$ exists under the small singular perturbation. Interestingly, unlike solitary wave solutions, the kink (anti-kink) wave solution doesn't persist because the corresponding Melnikov function has no zeros. Further, numerical simulations are utilized to verify the correctness of our analytical results.

Existence and instability of traveling pulses of Keller–Segel system with nonlinear chemical gradients and small diffusions

In this paper, we consider a generalized model of Keller–Segel system with a nonlinear chemical gradient and small cell diffusion. The existence of the traveling pulses for such equations is established by the methods of geometric singular perturbation (GSP) and trapping regions from dynamical systems theory. By the technique of GSP, we show that the necessary condition for the existence of traveling pulses is that their limiting profiles with vanishing diffusion can only consist of the slow flows on the critical manifold of the corresponding algebraic-differential system. We also consider the linear instability of these pulses by the spectral analysis of the linearized operators.

Geometric analysis of the Goldbeter minimal model for the embryonic cell cycle.

A minimal model describing the embryonic cell division cycle at the molecular level in eukaryotes is analyzed mathematically. It is known from numerical simulations that the corresponding three-dimensional system of ODEs has periodic solutions in certain parameter regimes. We prove the existence of a stable limit cycle and provide a detailed description on how the limit cycle is generated. The limit cycle corresponds to a relaxation oscillation of an auxiliary system, which is singularly perturbed and has the same orbits as the original model. The singular perturbation character of the auxiliary problem is caused by the occurrence of small Michaelis constants in the model. Essential pieces of the limit cycle of the auxiliary problem consist of segments of slow motion close to several branches of a two dimensional critical manifold which are connected by fast jumps. In addition, a new phenomenon of exchange of stability occurs at lines, where the branches of the two-dimensional critical manifold intersect. This novel type of relaxation oscillations is studied by combining standard results from geometric singular perturbation with several suitable blow-up transformations.

Time-delay effects on the dynamics of Liénard type equation with fast and slow variables

Time-delay effects on the dynamics of Liénard type equation with one fast variable and one slow variable are investigated in the present paper. By using the methods of stability switch and geometric singular perturbation, time-delay-induced complex oscillations and bursting are investigated, and in several case studies, the mechanism of the generation of the complex oscillations and bursting is illuminated. Numerical results demonstrate the validity of the theoretical results.

Effect of high-frequency stimulation on nerve pulse propagation in the FitzHugh–Nagumo model

We consider the FitzHugh-Nagumo model axon under action of a homogeneous high-frequency stimulation (HFS) current. Using a multiple scale method and a geometrical singular perturbation the- ory, we derive analytically the main characteristics of the traveling pulse. We show that the effect of HFS on the axon is determined by a parameter proportional to the ratio of the amplitude to the frequency of the stimulation current. When this parameter is increased, the pulse slows down and shrinks. At some threshold value, the pulse stops and its width becomes zero. The HFS prevents the pulse propagation when the parame- ter exceeds the threshold value. The analytical results are confirmed by numerical experiments performed with the original system of partial differential equa- tions.

Possible mechanisms underlying intermittent synchronous activity in the networks of excitatory and inhibitory bursting neurons

Basal ganglia circuits in Parkinson’s disease constitute a prominent example of neural system of coupled inhibitory and excitatory neurons, which exhibit synchronous activity [1]. The phase-locking of neural activity in this system, as analyzed in experimental data intraoperatively recorded in Parkinsonian patients, exhibits intermittent temporal dynamics [2]. The mechanisms of this intermittent synchronous dynamics make the subject of this study. The conductance-based network models of subthalamo-pallidal circuitry of basal ganglia have being shown to reproduce the intermittent temporal patterns of phase-locking observed in experiments with high fidelity [3]. We start with this network model of synaptically coupled excitatory subthalamic and inhibitory pallidal bursting neurons. We further reduce it to the model of two mutually coupled inhibitory neurons with self-inhibition. This network is presented at Figure ​Figure1.1. While real subthalamic neurons are excitatory, the resulting two-neurons network is adequate simplification of the original circuitry under assumption of high fidelity of responses of inhibitory pallidal cells. While this reduction may be associated with the loss of some other biologically realistic features, it produces a relatively generic circuit, therefore the studied mechanism may be quite general too. Figure 1 The network architecture. Each connection is inhibitory synapse. We used geometric dynamical systems and singular perturbation methods to reduce the full model to a simpler set of equations. Mathematical analysis was completed using three slow variables with two different time scales. Intermittently synchronous oscillations are generated by overlapped spiking which crucially depend on the geometry of slow phase plane and the interplay between slow variables as well as the strength of synapses. Two slow variables are responsible for the generation of out-of-phase stable solution and the other slower variable for irregular and intermittent activity pattern. The results of analysis can be traced to particular values of biophysical parameters (synaptic strength and parameters of calcium dynamics), which are known to be impacted in Parkinson’s disease.

Travelling waves for a biological reaction diffusion model with spatio-temporal delay

In this paper, we consider the reaction diffusion equations with spatio-temporal delay, which models the microbial growth in a flow reactor. Nonlocal spatial term, a weighted average in space, arises when the individuals have not necessarily been at the same point in space at previous time. By employing linear chain technique, geometric singular perturbation, and the center manifold theorem, we prove that the steady travelling wave does not only persist, but also it looks qualitatively the same as it do with no delay at all, under the introduction of delays, at least for small delay.