Geometric Distortion Artifacts Research Articles

Distortion-free water-fat separated diffusion-weighted imaging using spatiotemporal joint reconstruction.

Diffusion-weighted imaging (DWI) suffers from geometric distortion and chemical shift artifacts due to the commonly used Echo Planar Imaging (EPI) trajectory. Even with fat suppression in DWI, severe B0 and B1 variations can result in residual fat, which becomes both a source of image artifacts and a confounding factor in diffusion-weighted contrast in distinguishing benign and malignant tissues. This work presents a method for acquiring distortion-free diffusion-weighted images using spatiotemporal acquisition and joint reconstruction. Water-fat separation is performed by chemical-shift encoding. Spatiotemporal acquisition is employed to obtain distortion-free images at a series of echo times. Chemical-shift encoding is used for water-fat separation. Reconstruction and separation are performed jointly in the spat-spectral domain. To address the shot-to-shot motion-induced phase in DWI, an Fast Spin Echo (FSE)-based phase navigator is incorporated into the sequence to obtain distortion-free phase information. The proposed method was validated in phantoms and in vivo for the brain, head and neck, and breast. The proposed method enables the acquisition of distortion-free diffusion-weighted images in the presence of B0 field inhomogenieties commonly observed in the body. Water and fat components are separated with no obvious spectral leakage artifacts. The estimated Apparent Diffusion Coefficient (ADC) is comparable to that of multishot DW-EPI. Distortion-free, water-fat separated diffusion-weighted images in body can be obtained through the utilization of spatiotemporal acquisition and joint reconstruction methods.

Readout-segmented diffusion weighted imaging of the testis at 3.0T: comparison with single-shot echo-planar imaging.

The current study aimed to explore the feasibility of readout-segmented echo-planar imaging (RS-EPI) of the testis at 3.0T, by comparing with single-shot echo-planar imaging (SS-EPI) in qualitative image quality and quantitative apparent diffusion coefficient (ADC) values. 66 patients undergoing scrotal MRI for various clinical indications were included retrospectively. RS-EPI image quality was rated from 1 (severe distortion or artifact, or nondiagnostic) to 4 (nearly no distortion or artifact, or outstanding). The comparative image quality (RS- vs. SS-EPI) was rated from -2 (SS-EPI severe or greater conspicuity) to 2 (RS-EPI severe or greater conspicuity). The confidence interval of proportions (CIOP) of comparative image quality and Wilcoxon rank sum test were performed to assess the preferences between RS-EPI and SS-EPI. Paired samples t-test and Bland-Altman analysis were performed to compare the mean ADC values of RS-EPI and SS-EPI. The mean, maximum, and minimum ADC values measured by RS-EPI were compared in normal testicular parenchyma, benign and malignant intratesticular lesions. The evaluation of RS-EPI image quality showed RS-EPI with the characteristics of slight geometric distortion and susceptibility artifact, and good lesion conspicuity. The assessment of comparative image quality showed SS-EPI with obvious geometric distortion and susceptibility artifact, and RS-EPI preferred in lesion conspicuity. The CIOP ranged from 97 to 100% among three readers, with preferring to RS-EPI improving image quality (P < 0.001). There was a strong correlation and good agreement between mean ADC values measured by RS-EPI and SS-EPI. The mean, maximum and minimum ADC values by RS-EPI were significantly different in normal testicular parenchyma, benign and malignant intratesticular lesions. RS-EPI DWI of the testis improved image quality in geometric distortion, susceptibility artifacts, and lesion conspicuity, and provided highly correlated and consistent mean ADC values when compared to SS-EPI DWI, indicating the feasibility of RS-EPI DWI of testes.

A C-arm photon counting CT prototype with volumetric coverage using multi-sweep step-and-shoot acquisitions

Objective. Existing clinical C-arm interventional systems use scintillator-based energy-integrating flat panel detectors (FPDs) to generate cone-beam CT (CBCT) images. Despite its volumetric coverage, FPD-CBCT does not provide sufficient low-contrast detectability desired for certain interventional procedures. The purpose of this work was to develop a C-arm photon counting detector (PCD) CT system with a step-and-shoot data acquisition method to further improve the tomographic imaging performance of interventional systems. Approach. As a proof-of-concept, a cadmium telluride-based 51 cm × 0.6 cm PCD was mounted in front of a FPD in an Artis Zee biplane system. A total of 10 C-arm sweeps (5 forward and 5 backward) were prescribed. A motorized patient table prototype was synchronized with the C-arm system such that it translates the object by a designated distance during the sub-second rest time in between gantry sweeps. To evaluate whether this multi-sweep step-and-shoot acquisition strategy can generate high-quality and volumetric PCD-CT images without geometric distortion artifacts, experiments were performed using physical phantoms, a human cadaver head, and an in vivo swine subject. Comparison with FPD-CT was made under matched narrow beam collimation and radiation dose conditions. Main results. Compared with FPD-CT images, PCD-CT images had lower noise and improved visualization of low-contrast lesion models, as well as improved visibility of small iodinated blood vessels. Fine structures were visualized more clearly by the PCD-CT than the highest-available resolution provided by FPD-CBCT and MDCT. No perceivable geometric distortion artifacts were observed in the multi-planar PCD-CT images. Significance. This work is the first demonstration of the feasibility of high-quality and multi-planar (volumetric) PCD-CT imaging with a rotating C-arm gantry.

Reproducibility and feasibility of optic nerve diffusion MRI techniques: single-shot echo-planar imaging (EPI), readout-segmented EPI, and reduced field-of-view diffusion-weighted imaging

BackgroundDiffusion-weighted imaging (DWI) is an essential technique for optic nerve diseases. However, the image quality of optic nerve DWI is decreased by the distortions and artifacts associated with conventional techniques. In order to establish this method as a critical tool in optic nerve diseases, reproducibility and feasibility of new technical and conventional approaches of DWI need to be systematically investigated.MethodsDWIs were acquired using ss-EPI, readout-segmented EPI (rs-EPI) DWI, and reduced field-of-view (rFOV) DWI. 26 volunteers (mean age 31.2 years) underwent repeated MRI examinations in order to assess scan–rescan reproducibility and accuracy. The apparent diffusion coefficient (ADC) values (three ROIs were measured on each side) were determined to evaluate the reproducibility of each sequence and the differences between the three techniques. To quantify the geometric distortion artifacts, the length of optic nerve and the maximum angle of optic nerve were defined and compared to T2-weighted imaging. In addition, two readers evaluated four different aspects of image quality on 5-point Likert scales.Resultsrs-EPI DWI (ICCs: 0.916, 0.797 and 0.781) and rFOV DWI (ICCs: 0.850, 0.595 and 0.750) showed higher reproducibility (ICCs: ROI1, ROI2 and ROI3) of mean ADC value in all three ROIs than ss-EPI DWI (ICCs: 0.810, 0.442 and 0.379). The quantitative analysis of geometric distortion yielded a higher agreement of both rs-EPI DWI and rFOV DWI with T2-weighted imaging than ss-EPI. rs-EPI DWI (2.38 ± 0.90) and rFOV DWI (2.46 ± 0.58) were superior to ss-EPI DWI (1.58 ± 0.64) with respect to overall image quality and other aspects of image quality, each with P < 0.05. The mean ADC values of rFOV DWI were significantly lower than those of rs-EPI DWI and ss-EPI DWI in all three ROIs (P < 0.001).ConclusionsBoth rs-EPI DWI and rFOV-EPI DWI are suitable techniques for the assessment of diffusion restriction and provide significantly improved image quality compared with ss-EPI DWI. For methods using the same acquisition time, rFOV DWI is superior to ss-EPI DWI, while rs-EPI showed an overall superiority, although this technique took 47% longer to perform.

Efficient and Accurate Stitching for 360° Dual-Fisheye Images and Videos.

Back-to-back dual-fisheye cameras are the most cost-effective devices to capture 360° visual content. However, image and video stitching for such cameras often suffer from the effect of fisheye distortion, photometric inconsistency between the two views, and non-collocated optical centers. In this paper, we present algorithms for geometric calibration, photometric compensation, and seamless stitching to address these issues for back-to-back dual-fisheye cameras. Specifically, we develop a co-centric trajectory model for geometric calibration to characterize both intrinsic and extrinsic parameters of the fisheye camera to fifth-order precision, a photometric correction model for intensity and color compensation to provide efficient and accurate local color transfer, and a mesh deformation model along with an adaptive seam carving method for image stitching to reduce geometric distortion and ensure optimal spatiotemporal alignment. The stitching algorithm and the compensation algorithm can run efficiently for 1920×960 images. Quantitative evaluation of geometric distortion, color discontinuity, jitter, and ghost artifact of the resulting image and video shows that our solution outperforms the state-of-the-art techniques.

Development of an Integrated C-Arm Interventional Imaging System With a Strip Photon Counting Detector and a Flat Panel Detector.

Modern interventional x-ray systems are often equipped with flat-panel detector-based cone-beam CT (FPD-CBCT) to provide tomographic, volumetric, and high spatial resolution imaging of interventional devices, iodinated vessels, and other objects. The purpose of this work was to bring an interchangeable strip photon-counting detector (PCD) to C-arm systems to supplement (instead of retiring) the existing FPD-CBCT with a high quality, spectral, and affordable PCD-CT imaging option. With minimal modification to the existing C-arm, a 51×0.6 cm2 PCD with a 0.75 mm CdTe layer, two energy thresholds, and 0.1 mm pixels was integrated with a Siemens Artis Zee interventional imaging system. The PCD can be translated in and out of the field-of-view to allow the system to switch between FPD and PCD-CT imaging modes. A dedicated phantom and a new algorithm were developed to calibrate the projection geometry of the narrow-beam PCD-CT system and correct the gantry wobbling-induced geometric distortion artifacts. In addition, a detector response calibration procedure was performed for each PCD pixel using materials with known radiological pathlengths to address concentric artifacts in PCD-CT images. Both phantom and human cadaver experiments were performed at a high gantry rotation speed and clinically relevant radiation dose level to evaluate the spectral and non-spectral imaging performance of the prototype system. Results show that the PCD-CT system has excellent image quality with negligible artifacts after the proposed corrections. Compared with FPD-CBCT images acquired at the same dose level, PCD-CT images demonstrated a 53% reduction in noise variance and additional quantitative imaging capability.

Turbo Gradient and Spin Echo PROPELLER-Diffusion Weighted Imaging for Orbital Tumors: A Comparative Study With Readout-Segmented Echo-Planar Imaging.

Purpose: To qualitatively and quantitatively compare the image quality and diagnostic performance of turbo gradient and spin echo PROPELLER diffusion-weighted imaging (TGSE-PROPELLER-DWI) vs. readout-segmented echo-planar imaging (rs-EPI) in the evaluation of orbital tumors.Materials and Methods: A total of 43 patients with suspected orbital tumors were enrolled to perform the two DWIs with comparable spatial resolution on 3T. The overall image qualities, geometric distortions, susceptibility artifacts, and lesion conspicuities were scored by using a four-point scale (1, poor; 4, excellent). Quantitative measurements, including contrast-to-noise ratios (CNRs), apparent diffusion coefficients (ADCs), geometric distortion rates (GDRs), and lesion sizes, were calculated and compared. The two ADCs for differentiating malignant from benign orbital tumors were evaluated. Wilcoxon signed-rank test, Kappa statistic, and receiver operating characteristics (ROC) curves were used.Results: TGSE-PROPELLER-DWI performed superior in all subjective scores and quantitative GDR evaluation than rs-EPI (p < 0.001), and excellent interobserver agreement was obtained for Kappa value ranging from 0.876 to 1.000. ADClesion of TGSE-PROPELLER-DWI was significantly higher than those of rs-EPI (p < 0.001). Mean ADC of malignant tumors was significantly lower than that of benign tumors both in two DWIs. However, the AUC for differentiating malignant and benign tumors showed no significant difference in the two DWIs (0.860 vs. 0.854, p = 0.7448). Sensitivity and specificity could achieve 92.86% and 72.73% for TGSE-PROPELLER-DWI with a cutoff value of 1.23 × 10–3 mm2/s, and 85.71% and 81.82% for rs-EPI with a cutoff value of 0.99 × 10–3 mm2/s.Conclusion: Compared with rs-EPI, TGSE-PROPELLER-DWI showed minimized geometric distortion and susceptibility artifacts significantly improved the image quality for orbital tumors and achieved comparable diagnostic performance in differentiating malignant and benign orbital tumors.

Enhancement of MRI Imaging by Combining Ramp Sampling and Parallel Imaging Techniques in Cerebral Tumors

Our aim was to decrease geometric distortion artifact in DWI on brain by using different MR techniques such as ramp sampling and parallel imaging. The study was done on 15 patients, They were subject to routine brain MRI examination for different symptoms, examination was done on 1.5 T scanner, patients were divided to three group five patient in each group, geometric distortion in frontal and occipital lobe measured in the routine acquired DWI and after used the interested strategy compared to anatomical T2-FSE acquired in the routine examination then reduction percentage for each strategy was calculated. Application of parallel technique imaging showed significant artifact reduction in frontal lobe with approximately 54.36 % and about 34.8% in occipital lobe, while ramp sampling showed reduction with approximately 19% in frontal lobe and reduced artifact by 41.58% in the occipital lobe.&#x0D; &#x0D; Finally we conclude that using new techniques such as ramp sampling and parallel imaging used with EPI data acquisition reduced geometric distortion artifact and increased geometric resolution.

Reducing distortions in echo-planar breast imaging at ultrahigh field with high-resolution off-resonance maps.

PurposeDWI is a promising modality in breast MRI, but its clinical acceptance is slow. Analysis of DWI is hampered by geometric distortion artifacts, which are caused by off‐resonant spins in combination with the low phase‐encoding bandwidth of the EPI sequence used. Existing correction methods assume smooth off‐resonance fields, which we show to be invalid in the human breast, where high discontinuities arise at tissue interfaces.MethodsWe developed a distortion correction method that incorporates high‐resolution off‐resonance maps to better solve for severe distortions at tissue interfaces. The method was evaluated quantitatively both ex vivo in a porcine tissue phantom and in vivo in 5 healthy volunteers. The added value of high‐resolution off‐resonance maps was tested using a Wilcoxon signed rank test comparing the quantitative results obtained with a low‐resolution off‐resonance map with those obtained with a high‐resolution map.ResultsDistortion correction using low‐resolution off‐resonance maps corrected most of the distortions, as expected. Still, all quantitative comparison metrics showed increased conformity between the corrected EPI images and a high‐bandwidth reference scan for both the ex vivo and in vivo experiments. All metrics showed a significant improvement when a high‐resolution off‐resonance map was used (P < 0.05), in particular at tissue boundaries.ConclusionThe use of off‐resonance maps of a resolution higher than EPI scans significantly improves upon existing distortion correction techniques, specifically by superior correction at glandular tissue boundaries.

Open-source hardware designs for MRI of mice, rats, and marmosets: Integrated animal holders and radiofrequency coils

BackgroundSmall-animal MRI is an important investigative tool for basic and preclinical research. High-resolution anatomical and functional studies of the brain require artifact-free images that are acquired with a highly sensitive radiofrequency (RF) coil. New MethodThe animal holder plays an important role in mitigating image artifacts: motion artifacts are reduced by immobilizing the animal and geometric-distortion artifacts are reduced by accurately positioning the animal to improve static-field shimming. The RF coil, in turn, must provide high sensitivity over the whole brain and not physically interfere with the animal holder. To accomplish these tasks, the animal holder and RF coil should be designed in tandem. In this manuscript, animal holders and RF coils for mice, rats, and marmoset monkeys are described. Each animal holder includes components for anesthesia delivery and animal immobilization, as well as a compatible receive coil. Results/Comparison with Existing Method(s)Animal holders were capable of accurate and reproducible positioning (for the marmoset, this was in the stereotactic plane), consequently reducing geometric distortion in echo-planar images. Ear bars were designed in conjunction with receive-coil formers, thereby maximizing the sensitive region of coils, while concurrently reducing motion to less than a pixel over EPI time series. Motion and SNR were quantified to facilitate direct comparison to existing animal holders and RF coils. All computer-aided-design (CAD) files of animal holders and RF coils are provided to promote dissemination. ConclusionsThe confluence of design between the animal holder and RF coil provides a pragmatic solution for routine imaging of small animals.

The role of parallel imaging technique in decreasing geometric distortion artifact in diffusion weighted imaging of the brain

IntroductionThe purpose of this study was to evaluate the role of parallel imaging technique in obtaining a more accurate geometric representation of the studied anatomy and how far this technique can reduce the pixel displacement and increase resolution in echo planner imaging- diffusion weighted (EPI-DW) images of the brain. Patients & methodsThe study was done on 6 patients, they were subjected to routine brain MRI examination for different symptoms, examination was done on 1.5 T scanner, the degree of geometric distortion was measured in the phase encoding direction (from anterior to posterior (A/P) in the used sequence) in both DWI sequence acquired without and with parallel imaging technique respectively and was compared with T2-FSE sequence which has no geometric distortion as in EPI. ResultsParallel imaging technique reduced artifact (pixel displacement) in frontal and occipital lobes in addition to increasing resolution for EPI-DWI for the brain. This technique reduced pixel displacement in the frontal lobe by 47 ± 11.7% and 47.3 ± 11% reduction in the occipital lobe. ConclusionParallel imaging technique can be used with EPI-DWI to increase resolution and decrease geometric distortion artifact to acquire more accurate geometric representation of the acquired anatomy.

Body diffusion-weighted imaging using magnetization prepared single-shot fast spin echo and extended parallel imaging signal averaging.

This work demonstrates a magnetization prepared diffusion-weighted single-shot fast spin echo (SS-FSE) pulse sequence for the application of body imaging to improve robustness to geometric distortion. This work also proposes a scan averaging technique that is superior to magnitude averaging and is not subject to artifacts due to object phase. This single-shot sequence is robust against violation of the Carr-Purcell-Meiboom-Gill (CPMG) condition. This is achieved by dephasing the signal after diffusion weighting and tipping the MG component of the signal onto the longitudinal axis while the non-MG component is spoiled. The MG signal component is then excited and captured using a traditional SS-FSE sequence, although the echo needs to be recalled prior to each echo. Extended Parallel Imaging (ExtPI) averaging is used where coil sensitivities from the multiple acquisitions are concatenated into one large parallel imaging (PI) problem. The size of the PI problem is reduced by SVD-based coil compression which also provides background noise suppression. This sequence and reconstruction are evaluated in simulation, phantom scans, and in vivo abdominal clinical cases. Simulations show that the sequence generates a stable signal throughout the echo train which leads to good image quality. This sequence is inherently low-SNR, but much of the SNR can be regained through scan averaging and the proposed ExtPI reconstruction. In vivo results show that the proposed method is able to provide diffusion encoded images while mitigating geometric distortion artifacts compared to EPI. This work presents a diffusion-prepared SS-FSE sequence that is robust against the violation of the CPMG condition while providing diffusion contrast in clinical cases. Magn Reson Med 79:3032-3044, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

Robotic system for MRI-guided stereotactic neurosurgery.

Stereotaxy is a neurosurgical technique that can take several hours to reach a specific target, typically utilizing a mechanical frame and guided by preoperative imaging. An error in any one of the numerous steps or deviations of the target anatomy from the preoperative plan such as brain shift (up to mm), may affect the targeting accuracy and thus the treatment effectiveness. Moreover, because the procedure is typically performed through a small burr hole opening in the skull that prevents tissue visualization, the intervention is basically “blind” for the operator with limited means of intraoperative confirmation that may result in reduced accuracy and safety. The presented system is intended to address the clinical needs for enhanced efficiency, accuracy, and safety of image-guided stereotactic neurosurgery for deep brain stimulation lead placement. The study describes a magnetic resonance imaging (MRI)-guided, robotically actuated stereotactic neural intervention system for deep brain stimulation procedure, which offers the potential of reducing procedure duration while improving targeting accuracy and enhancing safety. This is achieved through simultaneous robotic manipulation of the instrument and interactively updated in situ MRI guidance that enables visualization of the anatomy and interventional instrument. During simultaneous actuation and imaging, the system has demonstrated less than 15% signal-to-noise ratio variation and less than 0.20 geometric distortion artifact without affecting the imaging usability to visualize and guide the procedure. Optical tracking and MRI phantom experiments streamline the clinical workflow of the prototype system, corroborating targeting accuracy with three-ax- s root mean square error 1.38 ± 0.45 mm in tip position and 2.03 ± 0.58° in insertion angle.

3D high-resolution diffusion-weighted MRI at 3T: Preliminary application in prostate cancer patients undergoing active surveillance protocol for low-risk prostate cancer.

To improve spatial resolution and image quality of diffusion-weighted (DW) MRI in detecting low-risk prostate cancer (lrPC) in patients undergoing active surveillance protocol (AS-PC), we propose the application of a diffusion-prepared balanced steady-state free precession (bSSFP) technique capable of multishot acquisition. Diffusion-prepared bSSFP was compared with single-shot DW echo planar imaging (SS-DW-EPI) at two prescribed resolutions (2.1 × 2.1 × 3.5mm(3) , 0.9 × 0.9 × 3.5 mm(3) ) in nine healthy subjects and nine AS-PC patients. Geometric distortion and susceptibility artifacts were quantitatively assessed in all subjects. In AS-PC patients, lesion detection via blinded multiparametric MRI including T1-weighted, T2-weighted, dynamic contrast-enhanced imaging, and along with either of two DW methods were evaluated against 12-point biopsy. Geometric distortion and susceptibility artifacts were significantly less for diffusion-prepared bSSFP at both prescribed spatial resolutions than SS-DW-EPI. Apparent diffusion coefficients of healthy prostate tissue were concordant between the two DW methods at both spatial resolutions. In AS-PC patients, multiparametric MRI with diffusion-prepared bSSFP had greater sensitivity (94%, 63%), accuracy (76%, 67%), positive-predictive value (54%, 48%), negative-predictive value (97%, 82%), and area under the curve (0.80, 0.67) than with SS-DW-EPI. The proposed diffusion-prepared technique with higher spatial resolution and improved image quality over SS-DW-EPI resulted in better multiparametric MRI detection of lrPC in AS-PC patients.

Improved B0‐distortion correction in diffusion MRI using interlaced q‐space sampling and constrained reconstruction

To enable high-quality correction of susceptibility-induced geometric distortion artifacts in diffusion magnetic resonance imaging (MRI) images without increasing scan time. A new method for distortion correction is proposed based on subsampling a generalized version of the state-of-the-art reversed-gradient distortion correction method. Rather than acquire each q-space sample multiple times with different distortions (as in the conventional reversed-gradient method), we sample each q-space point once with an interlaced sampling scheme that measures different distortions at different q-space locations. Distortion correction is achieved using a novel constrained reconstruction formulation that leverages the smoothness of diffusion data in q-space. The effectiveness of the proposed method is demonstrated with simulated and in vivo diffusion MRI data. The proposed method is substantially faster than the reversed-gradient method, and can also provide smaller intensity errors in the corrected images and smaller errors in derived quantitative diffusion parameters. The proposed method enables state-of-the-art distortion correction performance without increasing data acquisition time.

MO‐G‐BRA‐05: High Fidelity, Low Distortion Tetrahedral Diffusion‐Weighted MRI for Radiation Treatment Planning

Purpose: Diffusion‐weighted (DW) MR imaging provides supplemental information that may aid in target delineation during radiation treatment planning. However, geometric distortion artifacts and the inability to acquire higher b‐value DW images in tissues with short T2s have encumbered the utilization of DW MRI in radiation treatment planning. To rectify these issues, we present here a novel DW imaging approach that combines tetrahedral diffusion encoding and a multi‐shot, variable‐density spiral (MS‐VDS) acquisition. Methods: A custom MS‐VDS pulse sequence with Stejkal‐Tanner (ST) and twice refocused spin echo (TRSE) excitation schemes was implemented on a Siemens 3T scanner. For comparison to current state‐of‐the‐art, orthogonal and tetrahedral DW images were acquired in the brains of three healthy volunteers (FOV: 220mm2, matrix: 1282, interleaves: 16, TR: 3000ms, TH: 3mm, b‐values: 0/1000 s/mm2). Self‐navigated phase correction was applied during reconstruction to correct each spiral interleaf for eddy current and motion‐induced phase errors. Results: The MS‐VDS acquisition was effective at diminishing geometric distortion artifacts. The minimum echo times for the orthogonal ST, tetrahedral ST, and tetrahedral TRSE acquisitions were 79 ms, 56 ms, and 71 ms, respectively. Although the inherent self‐navigating capability of VDS was effective at diminishing eddy current and motion‐induced phase errors in the orthogonal ST images, the tetrahedral ST images were contaminated by residual eddy current‐induced blurring. However, the tetrahedral TRSE images exhibited quality similar to the orthogonal ST images, indicating that the TRSE sequence provided effective compensation of residual eddy currents. Conclusions: Tetrahedral encoding results in a reduction in minimum echo time for a given b‐value, facilitating acquisition of DW images in tissues with shorter T2s. A TRSE excitation is required to provide eddy current compensation in tetrahedral DW acquisitions. The combined MS‐VDS TRSE tetrahedral DW imaging method permits acquisition of high fidelity, low distortion DW images suitable for radiation treatment planning.

Real-time geometric lens distortion correction using a graphics processing unit

Optical imaging systems often suffer from distortion artifacts which impose important limitations on the direct interpretation of the images. It is possible to correct for these aberrations through image processing, but due to their calculation-intensive nature, the required corrections are typically performed offline. However, with image-based applications that operate interactively, real-time correction of geometric distortion artifacts can be vital. We propose a new method to generate undistorted images by implementing the required distortion correction algorithm on a commercial graphics processing unit (GPU), distributing the necessary calculations to many stream processors that operate in parallel. The proposed technique is not limited to affine lens distortions but allows for the correction of arbitrary geometric image distortion artifacts through individual pixel resampling at display rates of more than 30 frames per second for fully processed images (1024×768 pixels). Our method enables real-time GPU-based geometric lens distortion correction without the need for additional digital image processing hardware.

Metal-Induced Artifacts in MRI

The purpose of this article is to review some of the basic principles of imaging and how metal-induced susceptibility artifacts originate in MR images. We will describe common ways to reduce or modify artifacts using readily available imaging techniques, and we will discuss some advanced methods to correct readout-direction and slice-direction artifacts. The presence of metallic implants in MRI can cause substantial image artifacts, including signal loss, failure of fat suppression, geometric distortion, and bright pile-up artifacts. These cause large resonant frequency changes and failure of many MRI mechanisms. Careful parameter and pulse sequence selections can avoid or reduce artifacts, although more advanced imaging methods offer further imaging improvements.

MO‐FF‐A3‐01: Advantages of Multi‐Shot, Variable‐Density Spiral, Diffusion‐Weighted MR Imaging for Radiation Treatment Planning

Purpose: The prerequisite for intensity‐modulated radiation therapy (IMRT) is accurate target and critical structure definition. Diffusion‐weighted MRI provides information that may improve target delineation and, therefore, radiation treatment outcome. However, geometric distortion artifacts have hampered the use of diffusion‐weighted MRI in radiation treatment planning. We demonstrate here a multi‐shot (i.e. interleaved), variable‐density spiral method that not only diminishes geometric distortion artifacts, but also permits acquisition of higher resolution diffusion‐weighted images for use in radiation treatment planning. Method and Materials: A custom, multi‐shot, spin‐echo, variable‐density spiral sequence with bipolar diffusion gradients was implemented on a 3.0T GE scanner. High‐resolution, multi‐shot, diffusion‐weighted images were acquired on three healthy volunteers (FOV: 240mm2, matrix: 2562, interleaves: 32, TE: 50 msec, TR: 3000 msec, scan time: 3.2 minutes). To demonstrate the inherent self‐navigating capabilities of variable‐density spiral, diffusion‐weighted images were reconstructed without and with self‐navigated phase correction. For comparison to the current state‐of‐the‐art method, diffusion‐weighted images were also collected using a clinical, single‐shot, spin‐echo echo‐planar imaging (EPI) sequence with ramp sampling, partial k‐space, and parallel imaging (FOV: 240mm2, matrix: 1282, TE: 64.7 msec, SENSE, R=2, scan time: ∼1 minute). Results: The inherent self‐navigating capability of variable‐density spiral was effective at diminishing motion‐induced phase errors, encoded by the diffusion gradients, that varied from shot‐to‐shot. The multi‐shot diffusion‐weighted images exhibited good signal‐to‐noise ratio despite the 47% reduction in voxel volume compared to the diffusion‐weighted EPI images. Off‐resonance effects resulted in geometric distortions in ventral and rostral brain regions on diffusion‐weighted images collected with EPI, but did not compromise the geometric integrity of diffusion‐weighted images acquired with multi‐shot spiral. Conclusions: Multi‐shot, variable‐density spiral permits acquisition of high‐resolution, diffusion‐weighted images that do not suffer from geometric distortions that have previously prohibited their use in radiation treatment planning.

Performance of a novel piezoelectric motor at 4.7 T: applications and initial tests

The focus of this report was to test the performance of a novel piezoelectric motor under high magnetic field strength conditions and to investigate its potential applications in small animal magnetic resonance imaging (MRI). The device is made entirely of nonferrous materials and consists of four piezoelectric ceramic plates connected to a threaded metal tube through which a screw migrates. Ultrasonic vibrations of the threads inherent to the tube result in rotational and translational motion of the screw. Potential applications of the piezoelectric motor were investigated at 4.7 T. Firstly, phantom studies showed the motor was capable of accurately delivering low injection volumes ( approximately 0.01 ml). Dynamic contrast-enhanced MRI (DCE-MRI) studies performed in vivo using serially acquired T1-weighted, spin-echo imaging demonstrated the ability of the motor to reliably administer MR contrast-enhancing agent into live tumor-bearing mice without the introduction of image artifacts. In a second set of experiments, the motor allowed for controlled, dynamic repositioning of an anatomic slice of interest in a live animal to magnetic field isocenter, which resulted in reduced geometric distortion and image artifact due to improved radiofrequency and gradient field homogeneity. In conclusion, piezoelectric motors are MR compatible and offer great potential for improving MRI efficiency and throughput, particularly in a preclinical setting. Further investigation into applications such as automated capacitor tuning and impedance matching for MR transceiver coils is warranted.