Geometrical Arrangement Research Articles

Novel Nanoparticle‐Sized Cu(II), Ru(III), and Th(IV) Chelates Derived From Quinaldine Azo Dye Ligand: DFT Studies, Molecular Docking, and Applications in Drug Development and Catalysis

ABSTRACTThree novel complexes of copper(II), ruthenium(III), and thorium(IV) ions with quinaldine azo dye ligand HL were synthesized in nanoscale. Applying mass spectroscopy, electronic, infrared, 1H NMR, elemental, and thermal investigations, their structures were examined. By using azo nitrogen and hydroxyl oxygen atoms to coordinate as a monobasic bidentate, it was found that the ligand displayed bicapped square antiprism geometry with thorium(IV) metal ion, square pyramidal arrangement in copper(II) complex and octahedral configuration in ruthenium(III) complex. In order to confirm the complexes' geometrical arrangement, theoretical investigations were carried out using DFT/B3LYP/6–311 + G(d,p)/LANLDZ. The dipole moment, geometrical configuration, energetic parameters, and HOMO–LUMO gap of energy have been calculated. The compounds were formed in nanometric forms, as indicated by the mean particle sizes obtained by applying TEM. Based on TEM images for the complexes of copper(II), ruthenium(III), and thorium(IV), their average particle sizes were 11.04, 3.89, and 1.52 nm, respectively. PANC‐1 and A‐549 cells were used in the tests to evaluate the compounds' anticancer activity against the vinblastine reference. The findings confirm the great cytotoxicity effect of the free ligand and its complexes against the investigated cell lines using different doses of the examined compounds. Ru(III) and Cu(II) complexes exhibited cytotoxic effectiveness greater than that of vinblastine. The azo ligand, HL, exhibited the strongest antibacterial activity that is superior to that of the conventional medicines themselves and greater than that of its metal complexes. The most physiologically active compound's ideal conformation was found using molecular docking research, and the manner in which the Ru(III) complex and the enzyme of Panc‐1 link together was determined. It interacts in three different modes with the target receptor (PANC‐1): hydrophobic force, electrostatic force, and H‐bond. In addition to increasing the candidate activity, these interactions can be used to design and predict new, effective compounds. The capacity of the ligand and its complexes to act as heterogeneous catalysts for the oxidation of methyl violet 2B was examined. The ruthenium(III) and thorium(IV) complexes generated the greatest catalytic efficiencies.

Analysis of Signalized Roundabouts with Intelligent Transportation Systems - The Case of Gaziantep Junction 40 (Shell)

This study presents an analysis aimed at optimizing traffic flow at the Shell Intersection in Gaziantep. Due to increasing population and vehicle numbers, traffic problems in the city are growing, especially at central intersections. Using PTV-Vissim micro-simulation software, the current situation was analyzed and alternative scenarios were developed. Performance analyses were conducted on models created using field observations and peak hour traffic counts. The intersection, currently at service level "F", is targeted to be elevated to service levels "B" and "C" through the proposed Single Point intersection design and optimized signal plans. Results indicate that the proposed changes could reduce average vehicle delay by 85-93% and increase average speed by 195-239%. This study aims to contribute to the improvement of urban traffic management through the integration of intelligent transportation systems and geometric arrangements.

Analysis of the interactions between laser and arc due to different geometric arrangements and laser parameters in the additive manufacturing of Ti-6Al-4V

Additive manufacturing based on arc welding (=DED-Arc) has already established itself in the world of additive manufacturing. Recent process optimizations show the increased use in a hybrid process by irradiating an additional laser beam into the active arc zone. Numerous publications can be found in the literature for steel, aluminum, or bronze, in which, among other things, a strength-enhancing effect or an improved wall surface during this hybrid process is reported. The way in which the laser beam impacts the arc, at what distance, at what angle and with what spot size or focusing appears to be random in the publications and is always chosen differently in the literature. In order to close this knowledge gap, a corresponding holder for a DED-Arc torch and laser optic is developed, which allows these geometric factors to be systematically changed and also enables the titanium alloy Ti-6Al-4V to be processed in a hybrid process. By welding individual tracks and walls with different angles, distances and spot sizes of the two energy sources, a fundamental understanding of the laser-arc hybrid process is created. The results are analyzed using a high-speed camera and evaluated on the basis of surface measurements, micrographs, and power source values. This showed that the distance between the laser and the arc has the greatest effect on the additive process stability and the arc power sources values. In the range of 2–6 mm, there are, in some cases, strong fluctuations in the wire deposition and the arc voltage, so that this range should be avoided. It also showed that a wider spot sizes range of 360–600 μm can be used, whereby different ranges are recommended depending on the target size of uniform wall height or thickness. For the laser incidence angle, the most uniform walls across all tests are achieved at 20°. As the angle of incidence becomes flatter, the walls become more irregular, although there is no linear relationship or areas that should be avoided at all.

Machine Learning-Based Investigation of Atomic Packing Effects: Chemical Pressures at the Extremes of Intermetallic Complexity.

Intermetallic phases represent a domain of emergent behavior, in which atoms with packing and electronic preferences can combine into complex geometrical arrangements whose long-range order involves repeat patterns containing thousands of atoms or is incompatible with a 3D unit cell. The formation of such arrangements points to unexplained driving forces within these systems that, if understood, could be harnessed in the design of new metallic materials. DFT-chemical pressure (CP) analysis has emerged as an approach to visualize how atomic packing tensions within simpler crystal structures can drive this complexity and create potential functionality. However, the applications of this method have hitherto been limited in scope by its dependence on resource-intensive electronic structure calculations. In this Article, we develop machine learning (ML)-based implementation of the CP approach, drawing on the collection of DFT-CP schemes in the Intermetallic Reactivity Database. We illustrate the method with comparisons of ML-CP and DFT-CP schemes for a series of examples, before demonstrating its application with an exploration of one of the quintessential instances of complexity in intermetallic chemistry, Mg2Al3, whose high-temperature unit cell is a 2.8 nm cube containing 1227 atoms. An analysis of its ML-CP-derived interatomic pressures traces the origins of the structure to simple matching rules for the assembly of Frank-Kasper polyhedra. The ML-CP model can be immediately employed on other intermetallic systems, through either its web interface or a command-line version, with just a crystallographic information file.

Analysing fluid flow and heat transfer comparatively in flow passage systems: Evaluating thermal impacts and geometric configurations

This research thoroughly examines heat transfer and fluid flow in a passage flow system, highlighting the difficulties posed by different geometric arrangements and temperature conditions that may affect the system's performance. The main aim is to evaluate the impacts of different geometric characteristics on the velocity, pressure, and temperature profiles inside the flow route. These factors encompass cavity dimensions, tube diameter, and input conditions. An inclusive comparison of three different geometric designs at controlled temperatures is conducted using computational fluid dynamics (CFD) simulations. The findings indicate that the optimal geometric parameters improve thermal performance, with certain arrangements displaying improvements in heat transfer rates up to 30 %. In this regard, the higher cavity dimensions and suitable input velocities are exposed as advantages. The first sample exhibited a higher velocity of 0.024 m s-1 due to its simpler geometry and favorable heating conditions, while the third sample demonstrated a higher temperature of 465 K due to its complex cavity shape and multiple heating sources. This study suggests that enhancing efficiency in heat management applications necessitates a strategic design approach for passage flow systems, which must account for flow characteristics and geometric specifications. This research would provide insightful information for designers and engineers looking at enhancing fluid flow systems across a range of industrial applications.

Growth Patterns of Carbon Clusters Cn (n = 2-60) Identified via ABCluster Searching and DFT Benchmarking.

Recently, novel algorithms and enhanced computational capabilities have created unprecedented opportunities to precisely determine the geometric structures of clusters through theoretical calculations. In this study, we extensively investigated and characterized the geometric arrangements of the carbon clusters Cn (n = 2-60), employing the efficient ABCluster algorithm in conjunction with the gradient-corrected PBE and higher-accuracy B3LYP hybrid functional in density functional theory (DFT). New structures and a discernible structural growth pattern have been discovered. We observed a distinct preference in carbon clusters that transform from the linear chains (n = 2-9) to closed single-ring and planar structures (n = 10-27) and finally evolve to carbon cages (n = 28-60). A shortcut to construct the cage clusters was unveiled by inserting or rotating specific atoms within a distinct structural unit. The research results obtained from combining ABCluster with DFT calculations offer valuable new insights into the growth mechanisms and evolutionary trajectories of carbon clusters, providing a crucial theoretical framework for the development of innovative carbon-based materials and their potential applications.

Permeation mechanisms of hydrogen peroxide and water through Plasma Membrane Intrinsic Protein aquaporins.

Hydrogen peroxide (H2O2) transport by aquaporins (AQP) is a critical feature for cellular redox signaling. However, the H2O2 permeation mechanism through these channels remains poorly understood. Through functional assays, two Plasma membrane Intrinsic Protein (PIP) AQP from Medicago truncatula, MtPIP2;2 and MtPIP2;3 have been identified as pH-gated channels capable of facilitating the permeation of both water (H2O) and H2O2. Employing a combination of unbiased and enhanced sampling molecular dynamics simulations, we investigated the key barriers and translocation mechanisms governing H2O2 permeation through these AQP in both open and closed conformational states. Our findings reveal that both H2O and H2O2 encounter their primary permeation barrier within the selectivity filter (SF) region of MtPIP2;3. In addition to the SF barrier, a second energetic barrier at the NPA (asparagine-proline-alanine) region that is more restrictive for the passage of H2O2 than for H2O, was found. This behavior can be attributed to a dissimilar geometric arrangement and hydrogen bonding profile between both molecules in this area. Collectively, these findings suggest mechanistic heterogeneity in H2O and H2O2 permeation through PIPs.

Fabrication and Customization of Highly Porous PLGA Membranes Utilizing Near‐Field Electrospinning, Thermal Transitions, and Multilayer Strategies

Polymer porous membranes are crucial in various applications, including water filtration, tissue engineering, and drug administration. Conventional far‐field electrospinning (FFES) is widely used for producing polymeric membranes due to its cost‐effectiveness, scalability, and flexibility in using many polymers. However, FFES has limitations in controlling pore form and size, as it produces randomly oriented fibers that lead to inconsistent and noncustomizable pore sizes. To address these limitations, this work combines near‐field electrospinning (NFES) with thermal treatment of polymer fibers and membranes. NFES offers more precise control over fiber placement and alignment, producing well‐defined fiber patterns with consistent and customizable pore sizes without compromising the thickness of membranes. By exploring the interplay between polymer behavior, thermal effects, and capillary action, the differences in pore area under various temperatures and fiber spacings are characterized. Additionally, this study investigates the influence of multilayer infusion on pore size and geometric arrangement by examining multilayer configurations stacked at various angles. The results indicate that increasing the number of layers leads to decreased pore size, while the alignment of infused fibers affects pore shape. This integrated approach enhances control over membrane characteristics, improving the performance and consistency of polymer porous membrane fabrication across various applications.

Large-volume fully automated cell reconstruction generates a cell atlas of plant tissues.

The geometric shape and arrangement of individual cells play a role in shaping organ functions. However, analyzing multicellular features and exploring their connectomes in centimeter-scale plant organs remain challenging. Here, we established a set of frameworks named Large-Volume Fully Automated Cell Reconstruction (LVACR), enabling the exploration of three-dimensional (3D) cytological features and cellular connectivity in plant tissues. Through benchmark testing, our framework demonstrated superior efficiency in cell segmentation and aggregation, successfully addressing the inherent challenges posed by light sheet fluorescence microscopy (LSFM) imaging. Using LVACR, we successfully established a cell atlas of different plant tissues. Cellular morphology analysis revealed differences of cell clusters and shapes in between different poplar (P. simonii Carr. and P. canadensis Moench.) seeds, whereas topological analysis revealed that they maintained conserved cellular connectivity. Furthermore, LVACR spatiotemporally demonstrated an initial burst of cell proliferation, accompanied by morphological transformations at an early stage in developing the shoot apical meristem. During subsequent development, cell differentiation produced anisotropic features, thereby resulting in various cell shapes. Overall, our findings provided valuable insights into the precise spatial arrangement and cellular behavior of multicellular organisms, thus enhancing our understanding of the complex processes underlying plant growth and differentiation.

Spatial arrangement of the whiskers of harbor seals ( Phoca vitulina ) compared to whisker arrangements of house mice ( Mus musculus ) and brown rats ( Rattus norvegicus ).

We quantify the three-dimensional positions and orientations of the whiskers across the face of the harbor seal, and compare this geometry with the whisker arrays of rats and mice.

Conduction in heterogeneous systems in the low-frequency regime: variational principles and boundary integral equations.

The response of a homogeneous material to the presence of an external low-frequency oscillating electric field can be described by means of an effective complex conductivity. Low frequencies are characterized by negligible magnetic and radiative effects. The properties of heterogeneous systems, composed of multiple homogeneous regions, can be determined from those of the individual components and their geometric arrangement. Examples of such heterogeneous systems include soft materials such as colloidal suspensions, electrolyte systems, and biological tissues. The difference in the intrinsic conductivities between the homogeneous regions leads to the creation of an oscillating charge density localized at the interfaces between these regions. We show how to express key properties of these systems using this dynamic charge as a fundamental variable. We derive a boundary integral equation for the charges and reconstruct potentials and fields from its solution. We present a variational principle that recovers the fundamental equations for the system in terms of the oscillating charge and show that, in some formulations, the associated functional can be interpreted in terms of the power dissipated in the system. The boundary integral equations are numerically solved using a finite element method for a few illustrative cases.

X-ray polarization measurement of the gold standard of radio-quiet active galactic nuclei: NGC 1068

Context. NGC 1068 is the most observed radio-quiet active galactic nucleus (AGN) in polarimetry, yet its high-energy polarization has never been probed before due to a lack of dedicated polarimeters. Aims. Using the first X-ray polarimeter sensitive enough to measure the polarization of AGNs, we want to probe the orientation and geometric arrangement of (sub)parsec-scale matter around the X-ray source. Methods. We used the Imaging X-ray Polarimetry Explorer (IXPE) satellite to measure, for the first time, the 2–8 keV polarization of NGC 1068. We pointed IXPE at the target for a net exposure time of 1.15 Ms, in addition to using two Chandra snapshots of ∼10 ks each in order to account for the potential impact of several ultraluminous X-ray sources (ULXs) within IXPE’s field of view. Results. We measured a 2–8 keV polarization degree of 12.4% ± 3.6% and an electric vector polarization angle of 101° ± 8° at a 68% confidence level. If we exclude the spectral region containing bright Fe K lines and other soft X-ray lines where depolarization occurs, the polarization fraction rises to 21.3% ± 6.7% in the 3.5–6.0 keV band, with a similar polarization angle. The observed polarization angle is found to be perpendicular to the parsec-scale radio jet. Using a combined Chandra and IXPE analysis plus multiwavelength constraints, we estimated that the circumnuclear “torus” may sustain a half-opening angle of 50–55° (from the vertical axis of the system). Conclusions. Thanks to IXPE, we have measured the X-ray polarization of NGC 1068 and found comparable results, both in terms of the polarization angle orientation with respect to the radio jet and the torus half-opening angle, to the X-ray polarimetric measurement achieved for the other archetypal Compton-thick AGN: the Circinus galaxy. Probing the geometric arrangement of parsec-scale matter in extragalactic objects is now feasible thanks to X-ray polarimetry.

Electromagnetic and thermal performance study on a canted stack of REBCO tapes

Abstract Due to the critical current limitation of a single REBCO tape, stacking methods are generally employed to increase the current carrying capacity in practical high-temperature superconducting (HTS) applications. However, the overall critical current is strongly dependent on the self-magnetic field, which is influenced by the geometrical arrangement of conductors in the stack. Due to the brittle ceramic property, REBCO tapes are conventionally bent along the thickness side of the tape. However, the difference in bending radii of the outer and inner tape surfaces in the stack may lead to fracture deformation, thereby limiting the stacking number of REBCO tapes. To balance the stacking number with the bending issue, canted stack is proposed as a variant of normal stack for REBCO tapes. As a potential HTS intermediate component, it is imperative to conduct a comprehensive study on electromagnetic and thermal performance of canted stack. The unique geometrical arrangement of canted stack introduces new factors that affect critical current and transport AC loss. This paper concludes the special influencing factors of canted stack, including canted angle, stacking number, tape width, and spatial structure. The metal interleaving method is introduced for spatial distribution changing and thermal stability. Furthermore, orthogonal analysis is performed to elucidate the comprehensive correlation among these multiple factors. This study provides insights into the overall critical current and transport AC loss for different combinations of canted stack and establishes a predicting function for critical current to support the structural design of canted stack. Based on the specific case study, the improvement effect of canted stack is confirmed by both experiments and simulations.

Interaction of multiple micro-defects on the strength and failure mechanism of UD composites by computational micromechanics

The mechanical properties of unidirectional fiber-reinforced plastic (UD-FRP) are affected by a variety of micro-defects, such as random fiber arrangement, fiber misalignment and micro-voids. This study aims to investigate how these multiple micro-defects interact with each other and how they affect the strength and failure mechanism of UD-FRP by means of computational micromechanics. The composite behavior was simulated by the finite element analysis of a representative volume element of the composite microstructure in which the random distribution of fibers, the micro-voids, and the fiber misalignment are explicitly included. Both matrix and interface failure were considered for the loadings of transverse tension/compression, longitudinal compression, transverse/longitudinal shear, and their combination. It was found that these three micro-defects significantly weakened the compressive strength of UD-FRP along the longitudinal direction. Especially, the fiber misalignment magnified the effect of fiber arrangement, while the micro-voids reduce the effect. Besides, the fiber arrangement and micro-voids significantly weakened the tensile and compressive strength of UD-FRP along the transverse direction, but their interaction effect was not obvious. Moreover, transverse and longitudinal shear strength are significantly affected by micro-voids, but only longitudinal shear is affected by geometric fiber arrangement, and this effect is also weakened by micro-voids. Finally, the damage envelope under the combined longitudinal compression and transverse loads was obtained and compared with the Tsai-Wu failure criterion. The results showed that the Tsai-Wu criteria can provide an effective estimation for the failure locus under this biaxial loading condition.

Sandwich d/f Heterometallic Complexes [(Ln(hfac)3)2M(acac)3] (Ln = La, Pr, Sm, Dy and M = Co; Ln = La and M = Ru).

Sandwich d/f heterometallic complexes [(Ln(hfac)3)2M(acac)3] (Ln = La, Pr, Sm, Dy and M = Co; Ln = La and M = Ru) were prepared in strictly anhydrous conditions reacting the formally unsaturated fragment [Ln(hfac)3] and [M(acac)3] in a 2-to-1 molar ratio. These heterometallic complexes are highly sensitive to moisture. Spectroscopic observation revealed that on hydrolysis, these compounds yield dinuclear heterometallic compounds [Ln(hfac)3M(acac)3], prepared here for comparison purposes only. Quantum mechanical calculations supported, on the one hand, the hypothesis on the geometrical arrangement obtained from ATR-IR and NMR spectra and, on the other hand, helped to rationalize the spontaneous hydrolysis reaction.

A Type-II InP/MoTe2 van der waals heterostructure with adjustable electronic properties under external electric field and biaxial strain

We employed first-principles methods grounded in density functional theory to explore the geometric arrangement of the InP/MoTe2 heterojunction. Various configurations were examined to identify the stable state of the heterojunction. The findings highlight that the H1-type heterojunction, featuring an interlayer distance of 3.286 Å, shows notable stability, displaying a type-II alignment with an indirect bandgap of 0.630 eV. Under the influence of external electric fields and strain, shifts in the bandgap and charge transfer of the heterojunction are observed, as indicated by the study. The heterojunction shifts to a metal state from a semiconductor under the influence of electric fields and strain, while still retaining the intrinsic properties of each layer. InP/MoTe2 heterojunctions are harnessed to boost material absorption and expand the range of detectable wavelengths, particularly in the ultraviolet spectrum. Importantly, external electric fields and mechanical strain have the capability to adjust the optical properties of the heterojunction, expanding its applicability and future development potential in optoelectronic devices.

Piezofluorochromism in Covalent Organic Frameworks: Pressure-Induced Emission Enhancement and Blue-Shifted Emission.

Achieving enhanced or blue-shifted emission from piezochromic materials remains a major challenge. Covalent organic frameworks (COFs) are promising candidates for the development of piezochromic materials owing to their dynamic structures and adjustable optical properties, where the emission behaviors are not solely determined by the functional groups, but are also greatly influenced by the specific geometric arrangement. Nevertheless, this area remains relatively understudied. In this study, a successful synthesis of a series of bicarbazole-based COFs with varying topologies, dimensions, and linkages was conducted, followed by an investigation of their structural and emission properties under hydrostatic pressure generated by a diamond anvil cell. Consequently, these COFs exhibited distinct piezochromic behaviors, particularly a remarkable pressure-induced emission enhancement (PIEE) phenomenon with a 16-fold increase in fluorescence intensity from three-dimensional COFs, surpassing the performance of CPMs and most organic small molecules with PIEE behavior. On the contrary, three two-dimensional COFs with flexible structures exhibited rare blue-shifted emission, whereas the variants with rigid and conjugated structures showed common red-shifted and reduced emission. Mechanism research further revealed that these different piezochromic behaviors were primarily determined by interlayer distance and interaction. This study represents the first systematic exploration of the structures and emission properties of COFs through pressure-treated engineering and provides a new perspective on the design of piezochromic materials.

Piezofluorochromism in Covalent Organic Frameworks: Pressure‐Induced Emission Enhancement and Blue‐Shifted Emission

AbstractAchieving enhanced or blue‐shifted emission from piezochromic materials remains a major challenge. Covalent organic frameworks (COFs) are promising candidates for the development of piezochromic materials owing to their dynamic structures and adjustable optical properties, where the emission behaviors are not solely determined by the functional groups, but are also greatly influenced by the specific geometric arrangement. Nevertheless, this area remains relatively understudied. In this study, a successful synthesis of a series of bicarbazole‐based COFs with varying topologies, dimensions, and linkages was conducted, followed by an investigation of their structural and emission properties under hydrostatic pressure generated by a diamond anvil cell. Consequently, these COFs exhibited distinct piezochromic behaviors, particularly a remarkable pressure‐induced emission enhancement (PIEE) phenomenon with a 16‐fold increase in fluorescence intensity from three‐dimensional COFs, surpassing the performance of CPMs and most organic small molecules with PIEE behavior. On the contrary, three two‐dimensional COFs with flexible structures exhibited rare blue‐shifted emission, whereas the variants with rigid and conjugated structures showed common red‐shifted and reduced emission. Mechanism research further revealed that these different piezochromic behaviors were primarily determined by interlayer distance and interaction. This study represents the first systematic exploration of the structures and emission properties of COFs through pressure‐treated engineering and provides a new perspective on the design of piezochromic materials.

The Halogen Bond to Ethers - Prototypic Molecules and Experimental Electron Density.

Halogen bonds to dialkyl ether molecules have remained largely unexplored. We here address the synthesis and the structural chemistry of the first halogen-bonded noncyclic alkyl ethers, combining 1,4-diiodotetrafluorobenzene and the prototypic or commonly used ethers dimethyl ether, tetrahydrofuran, and methyl-tert-butyl ether as halogen acceptors. Two different structural motifs based on moderately strong halogen bonds were obtained: Discrete trimolecular aggregates are formed, and unexpected halogen-bonded supramolecular chain adducts feature oxygen-bifurcated halogen bonds with 1:1 donor:acceptor ratio. Both structure types may be selectively obtained even for the same ether by adjusting the stoichiometry in the crystallization experiments. The geometric features of the etheric oxygen center were found to be flexible, in contrast to the almost linear geometry about the halogen donor atom. A high-resolution X-ray diffraction experiment on the extended adduct of dimethyl ether allowed us to study the electronic details of the acceptor-bifurcated I···O···I halogen bonds. The electron density in the bond critical points and derived properties such as the Laplacian indicate essentially electrostatic interactions and explain the geometrical flexibility of ethers in halogen bonds. Our studies demonstrate the great versatility of ethers as halogen bond acceptors, that can occur in many geometrical arrangements and whose contribution to nature's structural designs should not be underestimated.

Morphology and photovoltaic architectural integration: students’ explorations on the ‘fifth façade’ in Lima’s multi-family projects

The aesthetic integration of solar systems with multi-family buildings remains rare in Latin American countries. This article considers sixty-five projects by architecture students in Lima (Peru) to establish compositional criteria using typological classifications of the solar system layout on the roofs, volumetric composition, and their relationship with façades and lower spaces. The results show a wide range of variables that must be resolved. However, there are limitations to understanding this integration when dealing with the inclination of roofs as well as the coherence and geometric arrangement in irregular configurations. More emphasis is required on understanding the interior organisation and its implications for solar systems when designing multi-family houses. Previous research on the quantification of solar incidence has already been published; however, more research for further aesthetic assessments in medium-density multi-family dwellings could be carried out in the future.