Purpose of the work: elucidation of the geological structure, manifestations of magmatism, geodynamics and metallogeny of one of the largest segments of the paleocontinental sector of the Lyapin megablock in the Urals. The peculiarity of the metallogenic specialization of the latter for uranium, thorium, rare metals, gold, optical quartz caused both increased interest and contradictory ideas about its geology, composition of rock complexes, their age and genesis. Methodology of the work: generalization, analysis and synthesis of materials from long-term studies of the geology and metallogeny of the region, including experimental, methodological, thematic and geological survey work (GDP-200/2 sheets P-40-VI, P-40-XII) with the involvement of extensive literary sources. Results. For the first time, on the basis of the created formation map and the developed author’s legend of the territory, the geological structure is shown, the geological structure, geodynamic conditions of formation, metallogenic features of uneven-aged rock associations are shown. The Lyapinsky megablock, which corresponds to the Lyapinsky mineragenic zone, is a component of the West Ural megazone of the Ural Mineragenic Province, including the Mankhambovsky, Malopatoksky, Nyartinsky and Sаledsky ore nodes. In their history of development, four metallogenic epochs are distinguished: the Pre-Riphean, Riphean-Cambrian, Paleozoic and MesozoicCenozoic, specialized in noble, rare, radioactive, and non-ferrous metals, the largest objects of which include the Yasnoye, Narodnoye, Turman, Chudnoye, Sosnovoye, Telaizskoye, Torgovskoye, Turupinskoye, Kholodnoye, Kozhimskoye, and others. Conclusions. The results obtained indicate that along with a certain ore specialization of metallogenic epochs, an important factor affecting the ore content of the territory is the activated suture zones established in the course of research, in the areas where the largest ore objects, including stratiform and porphyry deposits, are localized, as well as unconventional objects of the “structural-stratigraphic disagreement” type.