Geographical Regions In China Research Articles

A study on the physical aging characteristics of the older people over 70 years old in China.

In China, with the increase of life expectancy and the decrease of fertility rate, the aging problem has become increasingly prominent, and the physical problems of the older people over 70 years are the key and difficult problems. Based on the interactive logic between the aging problem and the older people health, in the study, a questionnaire survey and a nationwide physical fitness test were carried out on the older people over 70, to divide into different age groups (70-74 years old, 75-79 years old, 80-84 years old, 85 years old and older) and different genders. There were 8,400 valid samples, and 1,050 persons in each group. One-way ANOVA was used to compare the differences among groups of different ages, and a broken line chart was drawn to discuss the aging characteristics of various physical indexes of the older people over 70 in China. (1) Body morphology: male waist circumference, male waist-to-height ratio and female BMI showed a gradual downward trend with the increase of age; (2) Physiological function: male and female vital capacity showed a decreasing trend with the increase of age, while female pulse pressure showed a gradual upward trend. (3) Physical quality: the indicators of male and female muscle strength, flexibility quality, aerobic endurance and balance showed a downward trend with the increase of age. Vital capacity, flexibility quality, muscle strength, aerobic endurance, balance ability and so on, decreased significantly with the growth of age. 80 years old is the inflection point of the rapid decline of various indicators. Blood pressure, silent pulse, BMI, waist-to-hip ratio, waist-to-height ratio and other indicators did not change regularly with age. Indicators such as blood pressure, BMI, waist-to-hip ratio and waist-to-height ratio were in the high-risk range of metabolic diseases and cardiovascular and cerebrovascular diseases. The study conducted physical fitness test on the older people over 70 years old in 7 geographical regions of China, which is the first nationwide physical fitness test for the older people, which is an extension and expansion of the national physical fitness monitoring system, and also shows that the test indicators involved in the "Health fitness scale" are simple and feasible. And the study added a series of test data over 70 years old, which is the basis for scientific and reasonable formulation of physical fitness evaluation standards for the older people, and is of great significance for improving the national physical fitness database and grasping the dynamic changes of national physical health status, and providing data support for scientific guidance of physical exercise for the older people.

Application of improved glomerular filtration rate estimation by a neural network model in patients with neurogenic lower urinary tract dysfunction.

Previous studies have indicated that creatinine (Cr)-based glomerular filtration rate (GFR) estimating equations - including the new Chronic Kidney Disease Epidemiology creatinine (CKD-EPIcr) equation without race and the estimated glomerular filtration rate (eGFR) equation developed for the Chinese population - displayed suboptimal performance in patients with neurogenic lower urinary tract dysfunction (NLUTD), which limited their clinical application for detecting changes in GFR levels in all cohorts. To develop a neural network model based on multilayer perceptron (MLP) for evaluating GFR in Chinese NLUTD patients, and compare the diagnostic performance with Cr-based multiple linear regression equations for Chinese and the CKD-EPIcr equation without race. Single-center, cross-sectional study of GFR estimation from serum Cr, demographic data, and clinical characteristics in Chinese patients with NLUTD. A total of 204 NLUTD patients, from 27 different geographic regions of China, were selected. A random sample of 141 of these subjects was included in the training sample set, and the remaining 63 patients were included in the testing sample set. The reference GFR (rGFR) was assessed by the technetium-99m-labeled diethylenetriaminepentaacetic acid (99mTc-DTPA) double plasma sample method. A neural network model based on MLP was developed to evaluate GFR in the training sample set, which was then validated in the testing sample set and compared with Cr-based GFR equations. The MLP-based model showed significant performance improvement in evaluating the difference, absolute difference, precision, and accuracy of GFR estimation compared with the Cr-based GFR equations. Additionally, compared with the rGFR, we found that the MLP-based model provided an acceptable level of accuracy (greater than 85%, which was within a 30% deviation from the rGFR). The MLP-based model offered significant advantages in estimating GFR in Chinese NLUTD patients, and its application could be suggested in clinical practice.

The distribution of allergen sensitization and screening panel for respiratory allergic diseases in seven geographical regions of China: A multicenter study

The distribution of allergen sensitization and screening panel for respiratory allergic diseases in seven geographical regions of China: A multicenter study

Allergen sensitization and screening panel for respiratory allergic diseases in seven geographical regions of China

Allergen sensitization and screening panel for respiratory allergic diseases in seven geographical regions of China

Genomic analysis of lumpy skin disease virus asian variants and evaluation of its cellular tropism

Lumpy skin disease virus (LSDV) is a poxvirus that mainly affects cattle and can lead to symptoms such as severe reduction in milk production as well as infertility and mortality, which has resulted in dramatic economic loss in affected countries in Africa, Europe, and Asia. In this study, we successfully isolated two strains of LSDV from different geographical regions in China. Comparative genomic analyses were performed by incorporating additional LSDV whole genome sequences reported in other areas of Asia. Our analyses revealed that LSDV exhibited an ‘open’ pan-genome. Phylogenetic analysis unveiled distinct branches of LSDV evolution, signifying the prevalence of multiple lineages of LSDV across various regions in Asia. In addition, a reporter LSDV expressing eGFP directed by a synthetic poxvirus promoter was generated and used to evaluate the cell tropism of LSDV in various mammalian and avian cell lines. Our results demonstrated that LSDV replicated efficiently in several mammalian cell lines, including human A549 cells. In conclusion, our results underscore the necessity for strengthening LSD outbreak control measures and continuous epidemiological surveillance.

Chinese Snowscape As a Phenomenon

With unique aesthetic value, snowy landscapes are one of the most important subjects in Chinese painting. Due to their purity, elegance, serenity, simplicity and cold charm, snow scenes have been the focus of artists and scholars from long ago. The artistic features and cultural connotations of Chinese snow paintings have attracted the attention of many Chinese and Russian scholars. However, there is no typological study of snow landscape in their works. In this regard, the authors consider it necessary to actualize this topic. The article provides historical information about the study of snowy landscape, the history of Chinese painting masters’ appeal to this theme. The classification of snow painting depending on seasons, geographical regions of China, atmospheric phenomena, and themes is offered. The authors suggest their definition of the concept of “Chinese snow landscape” and the author’s classification of the content of snow paintings. The paper applies a typological approach to the analysis of “snow” scenes, and examines the development of traditional Chinese aesthetic contexts from ancient artistic codes to contemporary theories. Outstanding examples of snow landscape painting are presented. Snow painting is an important medium of Chinese cultural heritage that demonstrates the diversity and richness of Chinese culture. The given overview of China’s snow scene painting as a phenomenon in the work of Chinese artists can serve as a basis for further in–depth studies.

The effects of corporate social responsibility on innovation and performance of firms in China: a structural equation model analysis

Purpose This study aims to analyze and discuss the impact of corporate social responsibility (CSR) on firms’ performance, as well as to examine the interplay between CSR and the economy, society and innovation. Design/methodology/approach This paper collects data from 420 manufacturing firms across various geographical regions in China. By using a structural equation model, the paper investigates the impact of CSR on enterprise innovation, customer management capability, market competitiveness (MC) and firm financial performance. Findings The findings demonstrate that CSR performance positively contributes to enhancing the level of enterprise innovation, as well as customer management capability and market competitiveness. Furthermore, it assists enterprises in improving market competitiveness and elevating customer management capabilities. Thus, CSR can have a positive effect on the firm financial performance. Originality/value The outcomes presented in this paper offer valuable evidence regarding the influence of implementing CSR on different aspects of enterprise performance and innovation. Moreover, it provides practical recommendations for enterprises seeking to transition towards low-carbon practices and upgrade their manufacturing industry.

Current Status of Surveillance Systems for Human Respiratory Syncytial Virus

To conduct timely surveillance of the seasonal characteristics and disease burden of Human Respiratory Syncytial Virus (HRSV) in various geographical regions of China, and further develop more precise and effective prevention and intervention strategies, there is an urgent need for China to establish a nationwide, effective, and stable HRSV surveillance system. Through combining the current status of domestic and international HRSV surveillance systems and the existing surveillance framework in China, this study proposed an HRSV surveillance type applicable to China based on different surveillance purposes, and considering the feasibility of implementation. This article aimed to provide solid scientific and technical support to monitor the dynamic changes of HRSV epidemic timely, carry out a risk assessment and early warning, and further understand the disease burden of HRSV in China. It also helps to improve the diagnosis, prevention, and control of the HRSV diseases research and development, use, and evaluation of HRSV vaccines and drugs in China.

Preliminary Retrieval and Validation of Aerosol Optical Depths from FY-4B Advanced Geostationary Radiation Imager Images

Fengyun-4B (FY-4B) is the latest Chinese next-generation geostationary meteorological satellite. The Advanced Geostationary Radiation Imager (AGRI) aboard FY-4B is equipped with 15 spectral bands, from visible to infrared, suitable for aerosol optical depth (AOD) retrieval. In this study, an overland AOD retrieval algorithm was developed for the FY-4B AGRI. Considering the large directional variation in the FY-4B AGRI reflectances, a bidirectional reflectance distribution function (BRDF) database was built, through which to estimate land surface reflectance/albedo. Seasonal aerosol models, based on four geographical regions in China, were developed between 2016 and 2022 using AERONET aerosol products, to improve their applicability to regional distribution differences and seasonal variations in aerosol types. AGRI AODs were retrieved using this new method over China from September 2022 to August 2023 and validated against ground-based measurements. The AGRI, Advanced Himawari Imager (AHI), and Moderate-Resolution Imaging Spectroradiometer (MODIS) official land aerosol products were also evaluated for comparison purposes. The results showed that the AGRI AOD retrievals were highly consistent with the AERONET AOD measurements, with a correlation coefficient (R) of 0.88, root mean square error (RMSE) of 0.14, and proportion that met an expected error (EE) of 65.04%. Intercomparisons between the AGRI AOD and other operational AOD products showed that the AGRI AOD retrievals achieved better performance results than the AGRI, AHI, and MODIS official AOD products. Moreover, the AGRI AOD retrievals showed high spatial integrity and stable performance at different times and regions, as well as under different aerosol loadings and characteristics. These results demonstrate the robustness of the new aerosol retrieval method and the potential of FY-4B AGRI measurements for the monitoring of aerosols with high accuracy and temporal resolutions.

OP143 Association Of Different Venous Access Device With Health‑Related Quality Of Life Among Patients With Breast Cancer In China

IntroductionFew studies have explored the relationship between different venous access devices and health-related quality of life (HRQoL) among patients with breast cancer in China. This study aimed to evaluate the HRQoL of patients with breast cancer in China who underwent different venous access devices and to estimate the association between type of venous access device and HRQoL.MethodsA multicenter cross-sectional study was conducted in three tertiary hospitals from three major geographical regions in China. The final sample consisted of 472 patients aged from 18 to 78 years. The HRQoL was measured with the EQ-5D-5L scale and the EuroQoL Group visual analog scale. The venous access devices were divided into totally implantable venous access devices (TIVAD), peripherally inserted central catheters (PICC), and other devices. The multivariate regression analyses were used to explore the association between type of venous access device and HRQoL.ResultsOf 472 participants, 352 (75%) used the TIVAD device, 89 (19%) used the PICC device, and 31 (7%) used other devices. The TIVAD group had the highest EQ-5D-5L values (mean 0.89, standard deviation [SD] 0.178), while the PICC group had the lowest values (mean 0.85, SD 0.239). The EQ-5D-5L values for the other venous access device group was in between (mean 0.88, SD 0.127). However, the multivariate analysis indicated that the VAS and EQ-5D-5L scale dimension scores among patients were not significantly different (P>0.05) for the various central venous access devices.ConclusionsThis study demonstrates a non-significant association between the type of venous access device used and the HRQoL of patients with breast cancer in China. Although patients with a TIVAD experienced more pain during device insertion and access for chemotherapy, the negative effect on HRQoL scores was smaller than for PICCs.

A national survey of physicians regarding protection of patient privacy in China

ObjectivesThe significance of safeguarding patient privacy at a population level within public medical institutions remains insufficiently acknowledged despite the potential to enhance the protection awareness of physicians and of hospital management in clinical practice. We herein devised a survey to investigate the current state of patient privacy breaches in China and to ascertain its underlying rationales. MethodsWe conducted a comprehensive nationwide survey of 928 physicians in seven geographic regions of China through convenience and snowball sampling, enrolled physicians defined in the Chinese Health Statistics Yearbook, and measured the incidence of medical data breaches. Physicians’ perceptions and behaviors with respect to patient privacy protection and their attitudes toward hospital management were accessed through descriptive statistics. Multiple logistic regression analysis was also conducted with different adjustments of covariates for each model. ResultsOf the 937 respondents, 928 physicians were eligible and validated for the analysis. We estimated that 52.2 % (95 %CI, 48.9–55.4) of the physicians reported that they had disclosed their patients’ privacy. Master's (OR, 0.63 [95 %CI, 0.43–0.92]) and Ph.D. (OR, 0.59 [95 %CI, 0.35–1.00]) educational levels, scores on the understanding of patient privacy protection (OR, 0.89 [95 %CI, 0.80–0.99]), the presence of colleagues who had experienced data disclosure (OR, 7.00 [95 %CI, 5.02–9.77]), full-time department supervision (OR, 1.60 [95 %CI, 1.02–2.53]) and corresponding regulations (OR, 0.56 [95 %CI, 0.33–0.97]) for patient privacy protection in the hospital, restricted external equipment for computers (OR, 1.76 [95 %CI, 1.10–2.83]), and access to medical records (OR, 0.62 [95 %CI, 0.41–0.94]) were all associated with privacy breaches by physicians. ConclusionsIn general, patient privacy research and awareness of patient privacy protection are relatively deficient in China, with a remarkably high occurrence of disclosure. We posit that the identification of the factors underlying our results will provide evidence for appropriate hospital management, and that these factors may then be generalizable to other clinical settings. Public interest summaryPatient privacy breaches seem to be rarely mentioned and addressed regardless of the country, potentially due to its high sensitivity, while this is significant in clinical practice. In this study, we meant to find out the answers to the questions, “What is the situation of privacy disclosure in China public medical institutions?”, “Why does it happen?”, and “Is patient privacy protected enough? If not, how can we do better?”. Through conducting a survey among physicians, their answers were collected for further analysis. Our results appear to provide guidance for physicians on patient privacy protection and support hospital and information management.

Spatio-temporal evolution and the driving factors of municipal solid waste in Chinese different geographical regions between 2002 and 2020

Urbanization and economic development have contributed to the rapid and massive generation of municipal solid waste (MSW) and significant changes in spatial patterns, which are becoming a serious pollution problem. Previously, macroscopic studies on the driving factors of MSW have been widely conducted at the national level, but the exploration of the driving factors in different geographical regions on a regional scale has not received much attention in the previous literature. This study is based on China, spatial patterns were analyzed using spatial autocorrelation and movement of center of gravity, and time series clustering was used to explore temporal trends. Subsequently, Geodector was adopted to quantify the relationship between MSW generation and driving factors. The results of the study are as follows: 1) By analyzing the spatial pattern of MSW, this study found that MSW showed a spatial pattern of high in the southeast and low in the northwest during 2002–2020, and its separating line was the same as the Hu-line; the average center of gravity of MSW generation in the past 20 years was always located in Henan Province and shifted southward by 339.7 km. 2) The local spatial autocorrelation analysis results showed that the Low-Low clusters moved from southeast to northwest from 2002 to 2020, increasing to 20 cities. High-High clusters mainly appeared in the East Coast and South Coast regions, increasing from 8 to 17 cities in the last 20 years. 3) The analysis of driving factors by Geodetector revealed that Urbanization is the most critical dimension factor influencing MSW generation, with the strongest impact on the East Coast region. The next dimension is Economy, which has the most significant impact on MSW generation in the North West region. Energy is the third dimension that influences MSW generation, with the greatest impact on the North Coast region. The results of this study reveal trends in the spatial and temporal distribution of MSW in different geographic regions of China over the past 20 years and the impact of their driving factors, which can help the Chinese government take action to control MSW in a site-specific manner.

Evaluation energy flow and analysis of energy economy for agricultural yield production in different geographical regions of China

Abstract Dry and humid climates have different potentials for providing soil moisture. Agricultural drought is a confirmed criterion for evaluating production potential in agriculture, which is discussed in this research. Therefore, this research aims to investigate drought using meteorological and agricultural drought indicator data in four climatic regions of China (humid, semi-humid, semi-arid and dry). For this purpose, climatic information was collected in the last 20 years, and the values of the standard precipitation index (SPI) and reconnaissance drought index (RDI) were determined. Examining the indicators indicates that the indicators are high in all the years under review in dry areas. In the semi-arid region, there was a significant decrease in the average value of the indices in July and August in the years 2017–2022. Drought indicators did not show a critical situation in humid and semi-humid areas, and there was sufficient moisture for plants throughout the year. The results showed that there was a high correlation between the SPI and the RDI in all the identified areas. In addition to rainfall, the RDI also includes transpiration and is more sensitive, especially in dry areas where transpiration is higher than rainfall.

Incidence trends of primary liver cancer in different geographical regions of China from 1978 to 2012 and projections to 2032: An age-period-cohort analysis.

China accounted for 45.3% of new cases of primary liver cancer (PLC) worldwide in 2020. While variations in PLC incidence between different regions of China and decreasing incidence in overall China have been reported, incidence patterns have not been thoroughly explored by region. We examined the nearly status and temporal trends of PLC incidence in different geographical regions in China and project future trends. The age-standardized incidence rate (ASR) was estimated for 1978 to 2012 by different geographical regions and gender in China. Age-period-cohort model was adopted to evaluate age and birth cohort effects on the temporal trend of five registries of China (Hong Kong, Shanghai, Jiashan, Harbin and Zhongshan), Bayesian age-period-cohort model was adopted to project future trends for 2013 to 2032. PLC incidence in China exhibits marked geographical disparity, with the highest incidence in Southwest China, and gender differences being particularly pronounced in South China. While other registries exhibited decreasing trend, Zhongshan exhibited an increasing trend, with the cohort effect showing a marked upward trend for females born in 1916 to 1949 and males born in 1916 to 1962. During 2013 to 2032, the ASR appears to increase by 86.9% for men and 40.0% for women in Zhongshan, while the remaining registries will decline by around 50%. Since the high incidence of hepatitis B virus infection in early birth cohort, recent rise of nonviral risk factors and the severe aging of the Chinese population, it may be critical to tailor future prevention and control strategies for PLC to the distribution of risk factors in different geographical regions.

Exploring the cooling potential maps of a radiative sky cooling radiator-assisted ground source heat pump system in China

Practical implementation of radiative sky cooling (RSC) in an active manner requires thoughtful system design. This study proposes a hybrid system that combines ground source heat pump (GSHP) and all-day RSC radiators (RSCR) to improve the systematical energy efficiency and assesses the cooling potential of RSCR as a supplemental part in GSHP across China using regional meteorological data. The study systematically evaluates the advantages in the energy efficiency of the hybrid system, the temporal cooling potential variability of RSCR in seven geographic regions of China, and the effects of varied radiative coatings with different spectral properties on the cooling capacity. The results indicate that the annual average cooling power provided by RSCR ranges between 149.7 and 484.6 W/m2 across all regions of China, with the highest cooling potential of 336.5 W/m2 observed in the cold region of north China and the lowest cooling potential of 178.3 W/m2 in the tropical region of south China. Compared with the stand-alone GSHP system, the heat rejected into the ground can be reduced by 20.6% on the nationwide average, and the nationwide average coefficient of performance (COP) of the proposed system can be increased by 18.6% due to the additional cooling contributions from RSCRs. All seven regions show promising cooling capacities for using RSCR as a supplemental heat rejector in winter compared to summer, with the maximum cooling power production of 453.6 W/m2 observed in winter in northeast China, corresponding to a temperature drop in RSCRs of 4.1 °C. The comparison between the diurnal and nocturnal cooling power productions across China reveals that the nocturnal cooling potential is higher than the diurnal scenario, with an average deviation of −66.2%, ranging from −53.7% to −78.8%. Moreover, compared to the ideal RSCR, the practical RSCR has a smaller radiative cooling power production (−18.2%) but a larger convective cooling power production (+1.6%), resulting from the relatively higher surface temperature on the practical RSCR, and the ideal RSCR-assisted GSHP system is 5.0% higher than that of the practical RSCR-assisted GSHP system regarding the nationwide average COP. The findings of this study can provide valuable insights into the better utilization of this energy-saving technology across a variety of weather conditions in China.

Effect of weekend versus weekday admission on the mortality of acute ischemic stroke patients in China: an analysis of data from the Chinese acute ischemic stroke treatment outcome registry.

Due to disparities in medical resources in rural and urban areas as well as in different geographic regions in China, the effect of weekend versus weekday admission on the outcomes of acute ischemic stroke (AIS) patients is unknown. Our aim was to investigate whether the outcomes of AIS patients differ according to the day of admission in China. The data were extracted from the Chinese Acute Ischemic Stroke Treatment Outcome Registry (CASTOR), a multicenter prospective study database of patients diagnosed with AIS. The chi-square test (χ2) and logistic regression were used to assess mortality for weekday and weekend admissions among AIS patients stratified by rural or urban status and geographic region (including the eastern, northeastern, central, and western regions). In total, 9,256 patients were included in this study. Of these patients, 57.2% were classified as urban, and 42.8% were classified as rural. A total of 6,760 (73%) patients were admitted on weekdays, and 2,496 (27%) were admitted on weekends. There was no significant difference in the mortality rate among patients admitted on weekends compared with those admitted on weekdays in urban (7.5% versus 7.4%) or rural areas (8.8% versus 8.1%; p > 0.05). The mortality rate was the highest among patients admitted on weekends and weekdays (11.6% versus 10.3%) in the northeastern area, without statistical significance before and after adjusting for the patients' background characteristics (p > 0.05). In addition, regression analysis revealed that the mortality of patients admitted on weekdays was more likely to be influenced by regional subgroup, hospital level and intravenous thrombolysis than that of patients admitted on weekends. The weekend effect was not observed in the mortality of patients with AIS regardless of rural-urban status or geographic region in China.

First report of GI.1aP-GI.2 recombinants of rabbit hemorrhagic disease virus in domestic rabbits in China.

The rabbit hemorrhagic disease virus 2 (RHDV2 or GI.2) is a highly contagious agent leading to lethal disease in rabbits. It frequently recombines with other Lagovirus genus, generating epidemical variants with high pathogenicity. In this study, twenty-two liver samples tested positive for GI.2 VP60 gene, were collected in rabbit farms from several geographical regions in China. All GI.2 positive specimens were submitted for RT-PCR detection, nucleotide sequencing and phylogenetic analysis. In addition, suspected GI.2 recombinants were evaluated for virus virulence. The results showed that nine presumptive recombinants were identified by testing for RdRp-VP60 recombination. In these recombinants, four were selected to fully characterize the genome of novel GI.2 recombinant variants, which were described as GI.1aP-GI.2. The nucleotide sequence of these novel variants showed unique recombination pattern and phylogenetic features compared to currently prevalent GI.2 variants. Furthermore, this distinctive recombination of new variant SCNJ-2021 moderately enhanced the virulence of GI.2, even for rabbits vaccinated against parental GI.2. In conclusion, the novel GI.1aP-GI.2 recombinants were identified in rabbit industry in China for the first time, which expanded the knowledge on the phylodynamics and genomic diversity of GI.2 genotype. The rapid molecular evolution and varied pathogenicity of these virus recombinants highlight the urgent need for epidemiological surveillance and for future prevention of these neglected GI.2 variants.

Antibiotic susceptibility and clonal distribution of Staphylococcus aureus from pediatric skin and soft tissue infections: 10-year trends in multicenter investigation in China.

Skin and Soft Tissue Infections (SSTIs) Surveillance Network of S. aureus In Pediatrics in China was established in 2009 to routinely report epidemiological changes. We aimed to monitor the present antibiotic sensitivity and molecular characteristics of S. aureus and methicillin-resistant S. aureus (MRSA) from SSTIs in children nationwide and track the changes over the past decade. Patients diagnosed with SSTIs from the dermatology departments of 22 tertiary pediatric hospitals in seven geographical regions of China were recruited continuously from May 2019 to August 2021. S. aureus was isolated, and its sensitivity to 15 antimicrobials was evaluated using the broth microdilution method. The molecular characteristics of the MRSA isolates were determined through multilocus sequence typing (MLST) and staphylococcal cassette chromosome mec (SCCmec) typing. The presence of the Panton-Valentine leukocidin gene (pvl) was determined. The detection rate of S. aureus was 62.57% (1379/2204), among which MRSA accounted for 14.79% (204/1379), significantly higher than the result in previous study in 2009-2011 (2.58%, 44/1075). Compared with previous study, the sensitivity to cephalosporins and fusidic acid decreased to varying degrees, while that to chloramphenicol, ciprofloxacin, clindamycin, erythromycin, gentamicin, penicillin, and tetracycline increased significantly. The sensitivity to mupirocin, trimethoprim/sulfamethoxazole (TRISUL), and rifampicin still maintained at a high level (97.90%, 99.35% and 96.66% respectively). The leading multidrug resistance pattern of MRSA and methicillin-sensitive S. aureus (MSSA) were erythromycin-clindamycin-tetracycline (55.84%; 43/77) and erythromycin-clindamycin-chloramphenicol (27.85%, 44/158) respectively. 12 high-level mupirocin-resistant strains were detected, and notable differences in geographical distribution and seasonal variation were observed. The main types of MRSA were ST121 (46.08%, 94/204), followed by ST59 (19.61%, 40/204). SCCmec V (65.69%, 134/204) and SCCmec IV (31.86%, 65/204) were dominant epidemic types. ST121-V, ST59-IV, and ST22-V were the most prevalent clones nationwide. The detection rate of pvl had increased markedly from 9.09% (4/44) in 2009-2011 to 22.55% (46/204) in 2019-2021 (P<0.05). The antibiotic sensitivity and molecular characteristics of S. aureus from pediatric SSTIs has changed significantly over the past decade. To standardize medical care, provide timely and reasonable clinical treatment, and effectively manage infection control, Chinese pediatric SSTIs guidelines are urgently needed.

Proportion of liver cancer cases and deaths attributable to potentially modifiable risk factors in China.

Understanding the differences in the burden of liver cancer due to different risk factors across provinces is critical to informing and improving liver cancer prevention and control. In this study, we estimated the population attributable fractions (PAFs) of liver cancer in all 31 provinces of China in 2016. Prevalence estimates of risk factors were derived from representative surveys. We used pooled relative risks obtained from several recent large-scale pooled analyses or high-quality meta-analyses. We calculated PAFs using multiple formulas which included exposure prevalence and relative risk data stratified by sex, age and province, and then combined and created overall PAFs by sex, risk factors and risk factor groups. Approximately 252 046 liver cancer cases {69.5% [95% confidence interval (CI) 52.6, 76.5]} and 212 704 deaths [67.7% (95% CI 50.9, 74.6)] were attributable to modifiable risk factors in China in 2016. The overall PAF for liver cancer was approximately 1.5 times higher in men than in women, with the top three risk factors in men being hepatitis B virus (HBV), smoking and alcohol drinking, whereas in women, they were HBV, excess body weight and hepatitis C virus (HCV). Among the risk factor groups, infectious agents had the highest PAF, followed by behavioural factors and metabolic factors. The PAF for liver cancer caused by modifiable risk factors varies widely among provinces and socioeconomic and geographical regions in China. The use of tailored primary prevention strategies across provinces and socioeconomic and geographical regions has great potential to reduce the burden and disparities of liver cancer.

Identification, characterization, and expression analysis of PpCPK gene family in response to Alternaria-infected peach fruits collected from different geographical regions of China

Peach is a popular and economically important fruit tree highly susceptible to biotic and abiotic stresses, including diseases caused by fungi, bacteria and viruses, pests and insects that feed fruits and leaves. Alteranria is a deadly disease agent, a genus of fungi that can cause significant damage to plants and crops such as peaches. Here, we investigated the role of CPK genes against in Alternaria species. The calcium-dependent protein kinase (CPK) gene family plays a vital role in the biotic stress response of plants. In this study, we aimed to identify, characterize, and analyze the expression pattern of the PpCPK gene family in response to Alternaria-infected peach fruits collected from different geographical regions of China. Based on phylogenetic analysis, 17 PpCPK genes were identified and classified into seven groups. The physicochemical properties, gene structure, conserved domains, and motifs of the PpCPK genes were analyzed to understand their molecular characteristics further. The Ka/Ks ratio analysis revealed the evolutionary facets of duplication events of PpCPKs and predicted the divergence time between 23.5 and 43.6 million years ago. The promoter region analysis confirmed the presence of plant growth, light, stress, and hormone-related cis-elements in PpCPKs. Additionally, the expression pattern of PpCPKs was analyzed using real-time quantitative PCR in Alternaria-infected peach fruits from different regions of China. The results indicated a differential expression pattern of PpCPK genes responding to Alternaria infection, suggesting their potential role in defense against biotic stress. Overall, our study provides insights into the molecular mechanisms of PpCPK genes in response to biotic stress, which could aid in developing strategies for improving peach resistance to biotic stress.