Geographical Areas Research Articles

Prevalence of Helicobacter pylori infection in China from 2014-2023: A systematic review and meta-analysis

BACKGROUND Helicobacter pylori (H. pylori) stands as the predominant infectious agent linked to the onset of gastritis, peptic ulcer diseases, and gastric cancer (GC). Identified as the exclusive bacterial factor associated with the onset of GC, it is classified as a group 1 carcinogen by the World Health Organization. The elimination of H. pylori plays a crucial role in the primary prevention of GC. While the prevalence has declined in recent decades, H. pylori infection is still highly prevalent in China, accounting for a significant part of the disease burden of GC. Therefore, updated prevalence information for H. pylori infection, especially regional and demographic variations in China, is an important basis for the design of targeted strategies that will be effective for the prevention of GC and application of policies for H. pylori control. AIM To methodically evaluate the occurrence of H. pylori infection throughout China and establish a reference point for subsequent investigations. METHODS A systematic review and meta-analysis was conducted following established guidelines, as detailed in our methodology section. RESULTS Our review synthesized data from 152 studies, covering a sample of 763827 individuals, 314423 of whom were infected with H. pylori . We evaluated infection rates in mainland China and the combined prevalence of H. pylori was 42.8% (95%CI: 40.7-44.9). Subgroup analysis indicated the highest prevalence in Northwest China at 51.3% (95%CI: 45.6-56.9), and in Qinghai Province, the prevalence reached 60.2% (95%CI: 46.5-73.9). The urea breath test, which recorded the highest infection rate, showed a prevalence of 43.7% (95%CI: 41.4-46.0). No notable differences in infection rates were observed between genders. Notably, the prevalence among the elderly was significantly higher at 44.5% (95%CI: 41.9-47.1), compared to children, who showed a prevalence of 27.5% (95%CI: 19.58-34.7). CONCLUSION Between 2014 and 2023, the prevalence of H. pylori infection in China decreased to 42.8%, down from the previous decade. However, the infection rates vary considerably across different geographical areas, among various populations, and by detection methods employed.

Management of Fusarium Wilt of Lettuce

Abstract In recent years, Fusarium wilt, caused by Fusarium oxysporum f. sp. lactucae, has become the most important lettuce disease throughout the world. Since the pathogen is seed-transmitted, the disease spreads through infected seeds, favoured by the global commerce. We describe the biology and epidemiology of the pathogen, as well as the differentiation of four physiological races, with their distribution in different geographical areas. The reaction of the lettuce types and varieties to the pathogen are also described, as well as the diagnostic tools available for an appropriate detection of the pathogen, including the races. Like other soil-borne diseases, Fusarium wilt of lettuce is difficult to manage with a single product and/or with a single approach. At present, minimizing crop losses due to Fusarium wilt on lettuce entails the deployment of all available existing disease control tools within an integrated management programme. The first preventative strategy is the use of healthy seeds. Stock seeds should be produced in the areas associated with the lowest disease risk and subjected to standardized health analysis. Furthermore, seeds should be treated with chemical/physical or biological treatments. Among chemical tools, soil disinfestation is becoming very difficult due to the loss of registered fumigants. A careful monitoring of the race situation in the field would be useful for efficient use of genetic means of control. The seed industry is investing in the search of new varieties resistant to Fusarium wilt. Looking forward, the development of commercially acceptable cultivars of desired types of lettuce with high levels of resistance to Fusarium wilt as well as refinement of existing or development of new cultural, chemical and biofungicide tools should lead to more efficient and effective disease management. Information © The Authors 2024

Performance Assessment of ELISA Using the Trypanosoma cruzi-Specific Antigen Tc323 for the Diagnosis of Chronic Chagas Disease.

In the chronic phase of Chagas disease (CCD), diagnosis relies on detecting specific IgG antibodies due to the low or absent presence of the parasiteTrypanosoma cruzi in human blood. However, the performance of current serological tests is highly variable, lacking a "gold standard" assay with 100% sensitivity and specificity, which challenges the exploration of new biomarkers. In the present study, we evaluated the diagnostic accuracy of an optimized ELISA using the predicted immunogenic domains (called TcD3 and TcD6) of Tc323, a protein highly conserved among T.cruzi strains but absent in other clinically significant parasites such as Leishmania spp. This study was conducted using plasma or serum samples from CCD individuals with different clinical manifestations and living in endemic regions in Latin America, subjects with unrelated infectious diseases, and noninfected donors. The sensitivity and specificity of recombinant TcD3 were 90.8% and 92.6%, respectively, while rTcD6 displayed values of 93.1% and 93.6% for the same parameters. Area under curve (AUC) values were 0.949 for rTcD3 and 0.954 for rTcD6. The receiver operative characteristic (ROC) curve showed a highly significant difference between CCD individuals and noninfected donors. Cross-reactivity was 10.2% for rTcD3 and 8.2% for rTcD6 in subjects infected with leishmaniasis or with toxoplasmosis. In addition, the reactivity against rTcD3 differed among some geographical areas while no significant difference was found using both domains for the detection of T.cruzi-infected individuals with or without cardiac symptoms. Our findings show that the recombinant antigens rTcD3 and rTcD6 could be used as highly potential biomarkers for the serological diagnosis of CCD.

Cost Analysis of Penitentiary Systems and Comparison Between the Countries of the Council of Europe

Background: The objective was to analyze the budgets invested in prisons by the member states of the Council of Europe (CoE) and the relationships between the global cost, the cost incurred per single inmate, the number of inmates per 100,000 inhabitants (PPR), the gross domestic product (GDP) and per capita GDP. Methods: The data relating to the variables considered for the year 2020 were obtained from the SPACE-I 2021 of the CoE, the World Bank/OECD, and Eurostat. Regression models were used to evaluate the relationships between the PPR and the GDP, the daily cost per prisoner and per capita GDP, and between the PPR and the per capita GDP. A multiple correspondence analysis was performed to evaluate associations between the PPR, EU membership, cost per day, cost rate, geographical area, and inmate gender. Results: The daily expenditure per inmate in northern European countries reaches very high values, respectively: EUR 330.6 (Norway) and EUR 303 (Sweden), while, in the eastern countries, the values drop sharply (EUR 6.50 in Bulgaria and EUR 8.08 in Azerbaijani). The lowest PPR values are found in northern European countries, and the highest in the following countries: Russia, Turkey, Georgia, and Azerbaijan. Conclusions: Countries with a higher GDP per capita tend to have lower prison population rates and to invest larger amounts of funds for prison systems.

Occupational exposures in low- and middle-income countries: A scoping review.

Exposure to high levels of harmful agents in the workplace can significantly impact workers' health, contributing to morbidity and mortality. Levels of these exposures are often measured in high-income countries in research studies and, in some places, to monitor levels in line with health and safety regulations. However, less is known about workplace exposure levels in low- and middle-income countries (LMICs). Our aim was to describe the quantitative exposure measurements of different occupational agents across industries within LMICs. We conducted a scoping review of peer-reviewed publications available on Web of Science and PubMed from inception to 1 September 2023. Our search focused on quantitative occupational exposure measurements across industries in LMICs. We identified a total of 8,676 publications. After screening, 58 studies from 25 countries were retained for final review. China, Iran, and Tanzania contributed the greatest number of studies. Manufacturing, mining, and agriculture were the most studied sectors, with factory workers and miners being the most common job titles. Exposure measurements included vapour, gases, dust, and fumes (VGDF), solvents, metals, pesticides and particulate matter. Occupational exposure levels for the same industry varied widely across geographical regions. This review provides a comprehensive overview of occupational exposures in LMICs and highlights the absence of data in certain geographical areas and industries. The study contributes valuable insights for directing future research, and the need to optimise the assessment of occupational exposures in LMICs with the aim ultimately of reducing disease.

Deep-learning-based multi-timescale load forecasting in buildings: opportunities and challenges from research to deployment

Electricity load forecasting for buildings and campuses is becoming increasingly important as the penetration of distributed energy resources (DERs) grows. Efficient operation and dispatch of DERs require reasonably accurate predictions of future energy consumption in order to conduct near-real-time optimized dispatch of on-site generation and storage assets. Electric utilities have traditionally performed load forecasting for load pockets spanning large geographic areas, and therefore, forecasting has not been a common practice by buildings and campus operators. Given the growing trends of research and prototyping in the grid-interactive efficient buildings domain, characteristics beyond simple algorithm forecast accuracy are important in determining the algorithm’s true utility for smart buildings. Other characteristics include the overall design of the deployed architecture and the operational efficiency of the forecasting system. In this work, we present a deep-learning-based load forecasting system that predicts the building load at 1-hour intervals for 18 hours in the future. We also discuss challenges associated with the real-time deployment of such systems as well as the research opportunities presented by a fully functional forecasting system that has been developed within the National Renewable Energy Laboratory’s Intelligent Campus program.

Realising Rights of Nature across and beneath the Southern Ocean

ABSTRACT If the philosophical, ecological, moral and ethical imperatives for Rights of Nature (RON) in the Antarctic can be argued to be clear, given the limitations and failures of contemporary instrumental environmental management, the modalities of operationalising and applying these to the Antarctic marine environment, commonly understood as the Southern Ocean, are not. Securing progressive environmental policies is very much harder in the marine environment than ashore, everywhere. Structural complications of the existing Antarctic regime structure and the historic and contemporary regional geopolitics add to the challenges in the Southern Ocean, beyond those posed by RON. Classical Antarctic framings cast the Southern Ocean as either the area south of the Antarctic Convergence or as merely the area south of 60° South Latitude. Neither suffices for the purposes of RON. Antarctic biota cross even the Antarctic Convergence. In doing so, they enter spaces subject to extra-Antarctic Treaty System (ATS) international legal regimes including Regional Fisheries Management Organisations abutting the ATS area and/or coastal state jurisdictions in the sub-Antarctic. They also penetrate deep below the levels of the ocean hitherto operationally managed by the ATS. Even ‘within’ the ATS geographical area, the deep seabed and particular taxa (cetaceans) are formally subject to other regimes. The area of relevance for RON is thus neither coterminous with the geographical area nor the jurisdictional competence of the ATS. The relevant geographical area is a ‘Greater Southern Ocean’. The politico-legal context across multiple regimes meaningful to RON is extraordinarily complex and multi-tiered. Advancing a RON discourse across this huge and complex field likely entails a fragmented engagement with discrete jurisdictional and institutional entities, albeit an engagement informed by a unitary and coherent understanding and purpose. Necessary as this is, it will be neither simple nor quick.

Allocating investigative resources within the Hungarian police force

The distribution of authority and competence is essential for all organizations, including law enforcement. The main focus is not just the existence of this distribution but its actual functionality, particularly from a professional and scientific standpoint regarding resource allocation. Distributing work tasks involves determining the general investigative authority's capacity to respond to crimes across different geographical areas. The aim is to deploy the appropriate forces and tools to different cases. Efficient distribution of resources is crucial as it impacts the quality of criminal investigation work, minimizes crime-related costs, and mitigates social effects. This study aims to evaluate how well the current regulations and practices match investigative resources with arising tasks and what principles guide the allocation of police forces and assets for law enforcement purposes. The focus is on whether the police's investigative activities are effective socially and scientifically rather than purely from a statistical viewpoint.

Tenofovir and Hepatitis B Virus Transmission During Pregnancy: A Randomized Clinical Trial.

Standard care for preventing mother-to-child transmission (MTCT) of hepatitis B virus (HBV) in highly viremic mothers consists of maternal antiviral prophylaxis beginning at gestational week 28 combined with an HBV vaccine series and HBV immune globulin (HBIG) at birth. However, HBIG is unavailable in some resource-limited areas. To determine whether initiating tenofovir disoproxil fumarate (TDF) at gestational week 16 combined with HBV vaccinations for infants is noninferior to the standard care of TDF at gestational week 28 combined with HBV vaccinations and HBIG for infants in preventing MTCT in mothers with HBV and high levels of viremia. An unblinded, 2-group, randomized, noninferiority clinical trial was conducted in 7 tertiary care hospitals in China. A total of 280 pregnant individuals (who all identified as women) with HBV DNA levels greater than 200 000 IU/mL were enrolled between June 4, 2018, and February 8, 2021. The final follow-up occurred on March 1, 2022. Pregnant individuals were randomly assigned to receive either TDF starting at gestational week 16 with HBV vaccinations for the infant or TDF starting at gestational week 28 with HBV vaccinations and HBIG administered to the infant. The primary outcome was the MTCT rate, defined as detectable HBV DNA greater than 20 IU/mL or hepatitis B surface antigen positivity in infants at age 28 weeks. Noninferiority was established if the MTCT rate in the experimental group did not increase by more than an absolute difference of 3% compared with the standard care group, as measured by the upper limit of the 2-sided 90% CI. Among 280 pregnant individuals who enrolled in the trial (mean age, 28 years; mean gestational age at enrollment, 16 weeks), 265 (95%) completed the study. Among all live-born infants, using the last observation carried forward, the MTCT rate was 0.76% (1/131) in the experimental group and 0% (0/142) in the standard care group. In the per-protocol analysis, the MTCT rate was 0% (0/124) in the experimental group and 0% (0/141) in the standard care group. The between-group difference was 0.76% (upper limit of the 2-sided 90% CI, 1.74%) in all live-born infants and 0% (upper limit of the 2-sided 90% CI, 1.43%) in the per-protocol analysis. Both comparisons met the criterion for noninferiority. Rates of congenital defects and malformations were 2.3% (3/131) in the experimental group and 6.3% (9/142) in the standard care group (difference, 4% [2-sided 95% CI, -8.8% to 0.7%]). Among pregnant women with HBV and high levels of viremia, TDF beginning at gestational week 16 combined with HBV vaccination for infants was noninferior to the standard care of TDF beginning at gestational week 28 combined with HBIG and HBV vaccination for infants. These results support beginning TDF at gestational week 16 combined with infant HBV vaccine to prevent MTCT of HBV in geographic areas where HBIG is not available. ClinicalTrials.gov Identifier: NCT03476083.

Nuclear phylogenomics of Eperua (Leguminosae) highlights the role of habitat and morphological lability in dispersal and diversification across Amazonia and in the Caatinga-Cerrado ecotone.

Eperua is a genus of Neotropical trees that forms a major component of tropical lowland forests in Amazonia, especially in the Guiana Shield and on white-sand forests. One species occurs in the Cerrado-Caatinga ecotone, and the genus also inhabits riverine and terra firme forests. Species in Eperua exhibit one of two drastically different floral architectures and inflorescence types, each associated with distinct pollinators. Prior phylogenetic studies of Eperua have revealed an unstructured topology concerning floral architectures and inflorescence types. In addition, no investigation has been conducted on how the evolution of these traits and habitat preferences influenced the dispersal and diversification of Eperua. Using target capture sequencing, we inferred the most comprehensive phylogeny for Eperua to date, sampling all 19 known species, five for the first time. We used coalescence, concatenation, and network methods to infer the Eperua phylogeny and investigate sources of incongruence impacting resolution and support. We reconstructed the biogeographic history and ancestral states for the flower architecture, inflorescence type, and habitat preference. Our phylogenomic analyses successfully resolved relationships within Eperua, attributing conflicts between the species tree and concatenated tree to gene tree discordance linked to reticulation events. Biogeographical analyses indicate that Eperua originated and initially diversified in the white-sand forests of the Guiana Shield. A subsequent adaptation to riverine and terra firme forests enabled Eperua to expand into new habitats and regions. Still, its historical preference for white-sand forests probably accounts for its absence in the southern and western parts of Amazonia. Ancestral geographic areas and corolla morphotype reconstructions suggest that speciation in Eperua has occurred in sympatry, likely driven by pollinator shifts mediated by drastic changes in floral architecture.

Oncoming Revolution in the Next Generation of Cohort Studies

The world is changing rapidly, mainly due to the impact of megatrends that have an impact on the entire human life, particularly in medical sciences. Medical research methodologies such as cohort studies provide very critical information, but it is not clear what would be its destination in the future. In this short article, we have tried to offer a somewhat different perspective on the future of cohort studies by analyzing the texts and their conclusions from the author's viewpoint. According to our assessment, cohorts will play a key role in medical research, but their methodology will significantly change in terms of designing, implementing, analysing, and applying the findings. The new generation of cohort study extracts most of their information from electronic health records, and it is not just restricted to a particular geographic area. With the changes in the levels of occupational exposure, risk factors, and the introduction of Omics, likely, occupational and birth cohorts as well as human diseases will likely undergo fundamental changes in the future. Big data will provide researchers with new opportunities, but information extraction and analysis require a team of specialists from several scientific fields. Furthermore, participants are likely to play a more active role in setting priorities and implementing research findings.

LIFE-CYCLE AND ENERGY CONSUMPTION OF THE COMMERCIALLY AVAILABLE PASSENGER CARS

Today, passenger vehicle emissions alone represent 15% of global greenhouse gas emissions (GHG). The automobile industry is aware of this and has taken steps towards decarbonization over the past decade. Emissions related to the six phases of the life cycle were determined from the LCA database compiled on the basis of data collected on emissions during the life cycle of different types of vehicles, units, sizes and geographical areas. Typically, Internal Combustion Engine Vehicles (ICE) constantly emit CO2 while driving, whereas Battery Electric Vehicles (BEV) and Fuel Cell Electric Vehicles (FCEV) do not. The transition to an electric vehicle is only as clean as the energy source used to charge the vehicle. Each BEV car represents approximately 2.2 MWh/year of load on the country's electric power system, while due to the way energy is converted, the ICE car represents approximately 11.9 MWh/year of fuel-equivalent load.

Non-compete clauses in employment contracts: The case for regulatory response

Abstract In the employment context, non-competes are contractual terms which provide that once the employment ends the employee cannot work for another employer in the same industry or field (i.e. a competitor), within a specified geographic area, for a specified time. The existing law and practice regarding non-competes in Australia is plagued with confusion and uncertainty. Non-competes also have adverse economic consequences; they are associated with reduced employee mobility and consequent negative impacts on wages and productivity. The use of non-competes by Australian business has increased over the past 5 years and absent a policy response; this trend is likely to continue. Non-competes are no longer limited to highly paid executives but now apply to about one in five Australian workers, across income, age, occupational, and education groups. The distribution and prevalence of non-competes in Australia are broadly consistent with data in other developed economies. A number of jurisdictions within the Organisation for Economics Co-operation and Development have imposed restrictions on the use of non-competes. The US Federal Trade Commission is considering a ban on their use and, in the UK, the government has announced its intention to limit the term of non-competes to 3 months. In Australia, the Competition Minister has recently asked the Australian Competition and Consumer Commission and Treasury for advice on the competitive aspect of non-competes. The Australian Government released an Issues Paper (https://treasury.gov.au/sites/default/files/2024-04/c2024-514668-issues-paper.pdf#page40) – ‘Non-competes and other restraints: understanding the impacts on jobs, business and productivity’ in April 2024. The Issues Paper outlines the existing research and evidence in Australia and overseas on the use and effects of non-competes. A public consultation process will conclude in May 2024 and Treasury will advise the Government on the outcomes of the consultations by the end of 2024. After reviewing the arguments for and against restricting the ‘reach’ of non-competes, I conclude that the weight of the evidence favours a regulatory response to ameliorate the unfairness inherent in the existing law and practice. A number of possible regulatory responses are considered.

EGS SO25 - Ingestion of Sharp Foreign Bodies- Emerging Trends in a Large UK NHS Trust

Abstract Background Foreign body (FB) ingestion is a common medical problem. The type of object ingested depends on age, sex, socio-economic factors, geographical area, and nutritional habits. Accidental ingestion of hijab pins as a phenomenon has not been widely reported in the UK previously. Method Retrospective cohort study on all patients presenting with foreign body ingestion from July 2010 to January 2024. Patient medical records were reviewed, and data collected including mode of presentation, demographics, FB type and mode of ingestion (accidental/deliberate), admission details, radiology, management (conservative, endoscopic, surgery), morbidity and mortality and readmission rate. Data was recorded and analyzed using Microsoft Excel. Results 94 patients presented with FB ingestion of whom 39 ingested hijab pins. Median age was 19 (11-50) years. Median time from ingestion to presentation was 5 hours (0.5-120). All patients had abdominal Xray. The most common hijab pin location on presentation was in the stomach; n=27 (69%). Data on management was available in 38 patients, of whom 29 (76%) were managed conservatively, 6 (15%) had endoscopy and 3 (8%) had flexible nasal endoscopy (FNE). The reintervention rate was 3% with one patient managed conservatively subsequently having endoscopy. No complications, readmissions or mortality was observed. One OGD was therapeutic Conclusion We report increase in the incidence of FB ingestion with a significant proportion involving hijab pins. Young girls hold pins between their lips while styling their hijabs which can result in accidental ingestion. Although we report low morbidity and readmission rates, there is a 22% intervention rate. We believe there may be a causal link between increased accidental ingestion and popularity of social media content on elaborate hijab styling, some with millions of views each. There is a need to increase awareness on dangers of holding pins in the mouth whilst styling hijabs and alternate options such as hijab magnets

Genetic and biological insights into Hydatigera taeniaeformis in invasive black rats from southern Chile

IntroductionThis study investigates the genetic variability of Hydatigera taeniaeformis in black rats (Rattus rattus), a common tapeworm that infects cats and rodents worldwide. Despite its widespread presence and zoonotic potential, little is known about the genetic diversity of this parasite in the Americas.MethodsWe conducted DNA barcoding analysis using mitochondrial cox1 gene sequences using samples collected from 171 invasive wild black rats, captured in the temperate rainforest of Southern Chile. We also included two adult parasites isolated from road killed Kodkods (Leopardus guigna), a small felid species native to the Americas.ResultsOur findings revealed only two haplotypes, suggesting low genetic variability in a parasite that arrived in the Americas with the Spanish colonization.DiscussionThese haplotypes are more closely related to parasite populations from Peru, Africa, Australia, and Europe, suggesting an origin linked to the Spanish colonization, possibly from North Africa via the Canary Islands. The study also analyzed infection rates, parasite size, and their correlation with host body size, age, and weight, revealing significant patterns. These results provide new insights into the biogeography and genetic diversity of H. taeniaeformis in a new geographical area, enhancing our understanding of its evolutionary history.

Plasmodium vivax antigen candidate prediction improves with the addition of Plasmodium falciparum data.

Intensive malaria control and elimination efforts have led to substantial reductions in malaria incidence over the past two decades. However, the reduction in Plasmodium falciparum malaria cases has led to a species shift in some geographic areas, with P. vivax predominating in many areas outside of Africa. Despite its wide geographic distribution, P. vivax vaccine development has lagged far behind that for P. falciparum, in part due to the inability to cultivate P. vivax in vitro, hindering traditional approaches for antigen identification. In a prior study, we have used a positive-unlabeled random forest (PURF) machine learning approach to identify P. falciparum antigens based on features of known antigens for consideration in vaccine development efforts. Here we integrate systems data from P. falciparum (the better-studied species) to improve PURF models to predict potential P. vivax vaccine antigen candidates. We further show that inclusion of known antigens from the other species is critical for model performance, but the inclusion of only the unlabeled proteins from the other species can result in misdirection of the model toward predictors of species classification, rather than antigen identification. Beyond malaria, incorporating antigens from a closely related species may aid in vaccine development for emerging pathogens having few or no known antigens.

Post-pandemic face-to-face learning environments for undergraduate students: A scoping review protocol.

This scoping review explores the existing literature related to post-pandemic face-to-face learning environments for undergraduate students following their participation in virtual classes during the Covid-19 pandemic. The secondary objectives are focused to identify the cognitive; emotional, or communicative demands that characterize students; changes in pedagogical strategies; and primary recommendations regarding post-pandemic face-to-face education in the context of Covid-19. The global emergency created by the presence of COVID-19 has led to significant change in the daily lives of people worldwide, ranging from lockdowns to the proliferation of virtual channels for social interaction and learning. Interest in its effects remains relevant in various fields including social, economic, health, technological, and educational studies. The transition back to face-to-face studies in university settings requires new adjustment processes for both students and teachers, necessitating pedagogical transformations and addressing cognitive, emotional, communicative, and habituation demands. Studies on the return to face-to-face studies in university settings are relatively scarce and warrant in-depth research. This review will include studies completed and published in calendar years 2022 and 2024 that involve post-pandemic face-to-face learning environments for undergraduate students from any geographical area. This scoping review will follow the JBI methodology for conducting scoping reviews. The following databases will be used: Academic Search Complete, Inter-American Development Bank, CLACSO, and The UNESCO Institute for Higher Education in Latin America and the Caribbean (IESALC), Dimensions, DOAB, DOAJ, ERIC, LILACS, Psicodoc, Redalyc, Redib, Scielo, Scopus, Dialnet, Web Of Science, Latindex, Google Scholar, SocArXiv. The search will aim to locate publications without language restrictions from any geographic location, including peer-reviewed articles, grey literature, preprints, technical notes, and policy reports. Three independent reviewers will screen, retrieve and review full-text studies and extract data. Consensus will be sought in the event of disagreement. The search results will be presented in the PRISMA-ScR flowchart. A narrative summary will also be included (Tricco AC 2018). Registration of systematic reviews: Open Science Framework (https://doi.org/10.17605/OSF.IO/6P9QB).

Cultural Studies with Communities in South Africa: Implications for Participatory Development Communication and Social Change Research

This article theorizes the role of local and indigenous culture in its intersection with development initiatives. It argues that Communication for Development and Social Change (CDSC), through a cultural studies framework, strengthens the potentiality of democratization and participation within community-based development and social change settings. We advocate that applied cultural studies can facilitate agency (through voice and self-representation) in social interventions. This is a cultural studies approach that has been recontextualised from the Birmingham origin as read through Marxist development studies, first adapted and mobilized during the anti-apartheid struggle in developing cultural strategy, and more recently with efforts to indigenise research practices with research participants in the southern Kalahari. We draw on an example of the community-owned, state-funded, and privately operated !Xaus Lodge cultural tourism asset. We illustrate how CDSC strategies, influenced by applied cultural studies, can work with an agentic imperative to effect development and mutual understanding in a defined geographical area, where multiple stakeholder agendas, cultural backgrounds, and ontologies are to be negotiated.

A survey of ocular pathology in Warmblood horses in South Africa.

Warmblood horses are a popular breed around the world for equestrian sports. Previous studies have investigated ocular findings in other breeds of horses; however, no studies exist for the Warmblood breed. To determine the prevalence of ocular abnormalities in a convenience sample of Warmblood horses in South Africa and to determine if the prevalence of lens and chorioretinal lesions increase with age. Descriptive, observational study. Warmblood horses underwent a full ophthalmic examination which included a Schirmer tear test (STT), tonometry, fluorescein dye testing, slit lamp biomicroscopy and indirect ophthalmoscopy. Age was categorised into three groups namely <8 years old, 8-13 years old and 14+ years old for statistical analysis. Prevalence of lens and chorioretinal lesions were compared between age categories. One hundred and four horses (208 eyes) were examined. The age range was 5 months to 30 years (mean 11 years, standard deviation [SD] 6 years). Ocular pathology was noted in 125 eyes (60.1%) and 79 horses (76%). The highest number of lesions were noted in the choroid and retina, iris and lens. Chorioretinal lesions were seen in 100 eyes (48.1%) and in 65 horses (62.5%). Iridial lesions were seen in 19 eyes (9.1%) and 12 horses (11.5%). Cataracts were seen in 19 eyes (9.1%) and in 13 horses (12.5%). The presence of total chorioretinal lesions (eye level [p = 0.002]; horse level [p = 0.004]), focal chorioretinal lesions (eye level [p = 0.004]; horse level [p = 0.008]) and cataract (eye [p = 0.03]; horse level [p = 0.02]) were all shown to statistically increase with age. A small sample size and limited geographic area. There was a high prevalence of ocular pathology in this population of Warmblood horses in South Africa. This reiterates the importance of an ocular examination as a part of routine health checks, as well as during prepurchase examinations.

Freshwater salinisation: unravelling causes, adaptive mechanisms, ecological impacts, and management strategies.

Freshwater salinisation is a growing problem worldwide, affecting surface and groundwater resources. Compared with other global environmental issues, freshwater salinisation has been studied extensively in North America, Australia, and Europe but less so in South America, Asia, and Africa. Both the natural and anthropogenic sources can contribute for freshwater salinisation, through the concentration of dissolved salts in water rising above its normal levels. This review provides a comprehensive assessment of the causes of freshwater salinisation, the impacts on freshwater communities and ecosystem functions, the adaptive mechanisms for survival in an increasingly saline environment, and the management strategies available to control freshwater salinisation. Many human activities contribute to freshwater salinisation, including road salt use, agricultural practices, resource extraction, reservoir construction, and climate change. Aquatic organisms have evolved mechanisms to survive in increasingly saline environments, but excessive salinity can lead to mortality and non-lethal effects. Such effects can have cascading impacts on the structure and function of aquatic communities and ecosystem services. Therefore, monitoring programmes and chemical fingerprinting are needed to identify highly salinised areas, determine how various human activities contribute to freshwater salinisation, and implement management strategies. Furthermore, current research on freshwater salinisation has been limited to a few regions of the world. It is essential to expand the research further into exploring the impacts of salinisation on freshwater resources in unexplored geographic areas of the world that are mainly impacted by climate change scenarios.