Introduction: The Republic of North Macedonia and especially the field pit of Polog in terms of geographical position and climatic aspect is considered as a place with different variables such as: temperature, humidity, radioactive exposure, hilly-mountainous relief. The Sharr mountain in the west and the dry mountain in the north, limit the Polog field pit in all directions, such as north-west and south-east, causing the living environment to deteriorate in the winter period due to air, water and land pollutants. With special emphasis, we highlight the winter season when we have an alarming state of air pollution, such as certain regions of the Republic of North Macedonia and especially the region of the field pit of Polog with the cities of Tetovo and Gostivar and the surrounding area. Recently, the city of Tetova and its surroundings is considered one of the most polluted cities in the country, region and the largest in the world, then this phenomenon of pollution necessarily leads us to unwanted consequences for the population that lives and operates in this region. As a result of environmental factors such as air pollution and other related factors such as: stress, temperature, food, social genes, mental state and other related factors can lead to disorders in the human body and lead to diseases that attack the nervous and cardiovascular systems , skeletal and thyroid. Many studies talk about the alarming condition of patients who are affected by these diseases, therefore our paper will focus on the effect of these factors above all on the actual state of pollutants in the Polog region of North Macedonia. The purpose of the study: This paper aims to investigate the potential causes that can affect the health of the population of the Polog field pit and especially the city of Tetova and its surroundings. As a potential pollutants of the living environment, the following can be considered: carbon monoxide, carbon dioxide, sulfur dioxide, urban combustion from automobiles, combustion of various physical substances, chemical components from factories, smoke from chimneys from burning oil and coal, combustion from wood in the form of pellets, etc. Material and working method: In the study, fertilized chicken eggs were taken and incubated in the incubator for 21 days of incubation. The eggs were treated with different doses of air pollutant extract at certain stages of embryonic development. Using the stereomicroscope with macroscopic and microscopic method were analyzed ontogenetic changes in certain stages of embryonic development. Research results: The results of the research will give a real insight into the situation of the level of pollution of the living environment in the city of Tetovo and its surroundings and in the field pit of Pollog. The monitoring of the living environment can be followed by the treatment of air pollutants in certain doses in the form of ampoule therapy, and the negative effect of the given dose on the hen's eggs will be observed. All eggs with the highest dose of injection had a stagnated embryonic development, whereas egss with lower dose of injections had underdeveloped embryos. Conclusion: From the results of the research we can conclude that the potential pollutants from air pollutants can lead to consequences for the population living in this region but also for the living world in general. These factors can lead to disorders of the nervous system, cardiovascular, and thyroid disorders and other respiratory diseases. This research will give a real insight into the pollution of the living environment and the possible consequences of this at a local, regional and wider level.
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