Biological Prophylaxis as a Tool of Interventional EpidemiologyAbstract Number:2334 Boris Katsnelson, Larisa Privalova, Vladimir Gurvich, Sergey Kuzmin, Olga Malykh*, Ekaterina Kireyeva, Ilzira Minigaliyeva, Marina Sutunkova, Nadezhda Loginova, Sergey Yarushin, Julia Soloboyeva, Nataliya Kochneva Boris Katsnelson Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Russian Federation, E-mail Address: [email protected] Search for more papers by this author , Larisa Privalova Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Russian Federation, E-mail Address: [email protected] Search for more papers by this author , Vladimir Gurvich Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Russian Federation, E-mail Address: [email protected] Search for more papers by this author , Sergey Kuzmin Sverdlovsk Regional Rospotrebnadzor Department, Russian Federation, E-mail Address: [email protected] Search for more papers by this author , Olga Malykh* Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Russian Federation, E-mail Address: [email protected] Search for more papers by this author , Ekaterina Kireyeva Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Russian Federation, E-mail Address: [email protected] Search for more papers by this author , Ilzira Minigaliyeva Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Russian Federation, E-mail Address: [email protected] Search for more papers by this author , Marina Sutunkova Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Russian Federation, E-mail Address: [email protected] Search for more papers by this author , Nadezhda Loginova Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Russian Federation, E-mail Address: [email protected] Search for more papers by this author , Sergey Yarushin Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Russian Federation, E-mail Address: [email protected] Search for more papers by this author , Julia Soloboyeva Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Russian Federation, E-mail Address: [email protected] Search for more papers by this author , and Nataliya Kochneva Sverdlovsk Regional Rospotrebnadzor Department, Russian Federation, E-mail Address: [email protected] Search for more papers by this author AbstractEnvironment pollution with many chemicals is very persistent, and so population’s exposure to them can be virtually irremovable. For some chemicals in the workplace environment reliably safe low exposure levels are technically unattainable or presumably nonexistent (e.g. for genotoxic carcinogens). Therefore, to supplement technical and managerial ways of decreasing harmful exposures to as low levels as possible, the ‘biological prophylaxis’ aims at enhancing host’s protective mechanisms. During a long period we tested ‘bioprophylactic complexes’ (BPCs) comprising substances with expected beneficial influence on the toxicokinetics and/or toxicodynamics (pectins, glutamate, methionine, acetyl cysteine, glycine, vitamins, calcium, iron, iodine, trace elements, fish oils rich with ?-3 PUFA) in animal experiments modeling isolated or combined chronic or subchronic exposures to silica, asbestos, monazite, lead, chromium, arsenic, manganese, nickel, vanadium, nanosilver, nanocopper, formaldehyde, phenol, naphthalene, benzo(a)pyrene. When proved protectively effective BPCs were subjected to controlled field trials on restricted groups of volunteers. Once the effectiveness and safety of a BPC was established, it was recommended for practical use, first of all, in the most vulnerable population groups (children, pregnant women) and in the most harmful occupations. At each stage of this work the effectiveness of the above systemic approach was successfully demonstrated. All BPCs tested up to now proved capable of mitigating systemic toxicity, cytotoxicity, fibrogenicity, and mutagenicity of the above-listed chemicals. Our experience has been extended across and outside the Middle Urals region. Thus in the environmental health risk management controlled enhancing of organism’s resistance to harmful effects of pollutants can play an important part as a way to proceed from analytical epidemiology to population health protection.