Thecombination of chemo- and radiotherapy used as main treatment of locally advanced cervical cancer (CC) may lead to side effects in healthy cells, which undermine theeffectiveness of treatment and quality of life. Theassessment of damage level in healthy radiosensitive cells from thetumor environment before thetreatment is important in order to predict and prevent remote side effects of radiation. To study theoxidative metabolism and genetic disorders in peripheral blood lymphocytes (PBL) of primary CC patients in order to evaluate thepossibilities of predicting radiation complications based on themolecular and biological properties of PBL. Peripheral blood samples were collected from 13primary CC patients T1-4N0-1M0-1, and PBL were routinely isolated. Theoxidative metabolism (mitochondrial trans-membrane potential, superoxide anion radical (О2•) generation, reactive oxygen species (ROS) production in PBL as well as thelevel of SH-groups in plasma and pro/antioxidant ratio in hemolysates were examined. Thedevelopment of genetic instability was determined by estimation of DNA double-strand breaks (DNA-DSB), frequency and spectrum of chromosome aberrations and apoptosis. Themarked increase in theintensity of О2• generation in PBL (1.5-fold), depletion of SH-groups content (1.6-fold) and a shift in thepro-antioxidant balance (1.4-fold) towards its prooxidant component were observed in theblood of primary CC patients as compared to healthy individuals. These oxidative stress related events were accompanied by an increase in thelevel of DNA-DSB (2.1-fold), apoptosis (3.5-fold) and frequency of cells with chromosome aberrations (3.9-fold). On thecontrary, significant decrease in mitochondrial trans-membrane potential (2.0-fold) and ROS generation in PBL (4.0-fold) were detected. Preliminary data indicate a violation of redox processes regulation, a shift in thepro-antioxidant balance towards its pro-oxidant component, accompanied by an increase in thelevel of DNA damage, development of genetic instability and apoptotic death of blood lymphocytes in primary CC patients.