Background: Load balancing of communication-intensive applications, allowing efficient resource utilization and minimization of power consumption is a challenging multi-objective virtual machine (VM) placement problem. The communication among inter-dependent VMs, raises network traffic, hampers cloud client’s experience and degrades overall performance, by saturating the network. Introduction: Cloud computing has become an indispensable part of Information Technology (IT), which supports the backbone of digitization throughout the world. It provides shared pool of IT resources, which are: always on, accessible from anywhere, at anytime and delivered on demand, as a service. The scalability and pay-per-use benefits of cloud computing has driven the entire world towards on-demand IT services that facilitates increased usage of virtualized resources. The rapid growth in the demands of cloud resources has amplified the network traffic in and out of the datacenter. Cisco Global Cloud Index predicts that by the year 2021, the network traffic among the devices within the datacenter will grow at Compound Annual Growth Rate (CAGR) of 23.4% Methods: To address these issues, a communication cost aware and resource efficient load balancing (CARE-LB) framework is presented, that minimizes communication cost, power consumption and maximize resource utilization. To reduce the communication cost, VMs with high affinity and inter-dependency are intentionally placed closer to each other. The VM placement is carried out by applying the proposed integration of Particle Swarm Optimization and non-dominated sorting based Genetic Algorithm i.e. PSOGA algorithm encoding VM allocation as particles as well as chromosomes. Results: The performance of proposed framework is evaluated by the execution of numerous experiments in the simulated datacenter environment and it is compared with the state-of-the-art methods like, Genetic Algorithm, First-Fit, Random-Fit and Best-Fit heuristic algorithms. The experimental outcome reveals that the CARE-LB framework improves 11% resource utilization, minimize 4.4% power consumption, 20.3% communication cost with reduction of execution time up to 49.7% over Genetic Algorithm based Load Balancing framework. Conclusion: The proposed CARE-LB framework provides promising solution for faster execution of data-intensive applications with improved resource utilization and reduced power consumption. Discussion: In the observed simulation, we analyze all the three objectives, after execution of the proposed multi-objective VM allocations and results are shown in Table 4. To choose the number of users for analysis of communication cost, the experiments are conducted with different number of users. For instance, for 100 VMs we choose 10, 20,...,80 users, and their request for VMs (number of VMs and type of VMs) are generated randomly, such that the total number of requested VMs do not exceed number of available VMs.