In this paper, we study the existence and multiplicity of homoclinic solutions for following Hamiltonian systems with asymptotically quadratic nonlinearities at infinity \begin{eqnarray*} \ddot{u}(t)-L(t)u+\nabla W(t,u)=0. {eqnarray*} We introduce a new coercive condition and obtain a new embedding theorem. With this theorem, we show that above systems possess at least one nontrivial homoclinic orbits by Generalized Mountain Pass Theorem. By Variant Fountain Theorem, infinitely many homoclinic orbits are obtained for above problem with symmetric condition. Our asymptotically quadratic conditions are different from previous ones in the references.
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