This paper presents a new method to numerically solve the nonlinear time-fractional generalized Kawahara equations (NTFGKE) with uniform initial boundary conditions (IBCs). A class of modified shifted eighth-kind Chebyshev polynomials (MSEKCPs) is introduced to satisfy the given IBCs. The proposed method is based on using the operational matrices (OMs) for the ordinary derivatives (ODs) and the fractional derivatives (FDs) of MSEKCPs. These OMs are employed together with the spectral collocation method (SCM). Our presented algorithm enables the extraction of efficient and accurate numerical solutions. The convergence of the suggested method and the error analysis have been developed. Three numerical examples are presented to demonstrate the applicability and accuracy of our algorithm. Some comparisons of the presented numerical results with other existing ones are offered to validate the efficiency and superiority of our approach. The presented tables and graphs demonstrate that the proposed approach produces approximate solutions with high accuracy.