In this paper, we focus on stochastic delay differential equations in the G-framework (G-SDDEs). We introduce the practical stability to examine whether the performance of G-SDDE near an unstable equilibrium point is acceptable. We establish a new generalized Gronwall inequality based on which we prove the practical mean-square (PMS) exponential stability of G-SDDE. We also establish the stability equivalence between the discrete and the continuous EM approximations for G-SDDE and then show that the continuous EM approximation can preserve the PMS exponential stability of G-SDDE. One numerical experiment is conducted to confirm our theoretical results.