This study proposes a novel system for accurately predicting grout’s uniaxial compressive strength (UCS) in fully grouted rock bolting systems. To achieve this, a database comprising 73 UCS values with varying water-to-grout (W/G) ratios ranging from 22 to 42%, curing times from 1 to 28 days, the admixture of fly ash contents ranging from 0 to 30%, and two Australian commercial grouts, Stratabinder HS, and BU-100, was built after conducting comprehensive series of experimental tests. After building the dataset, a metaheuristic technique, the jellyfish search (JS) algorithm was employed to determine the weight of base models in the ensemble system. This system combined various data and modelling techniques to enhance the accuracy of the UCS predictions. What sets this technique apart is the comprehensive database and the innovative use of the JS algorithm to create a weighted averaging ensemble model, going beyond traditional methods for predicting grout strength. The proposed ensemble model was called the weighted averaging ensemble model (WAE-JS), in which the obtained results of several soft computing models such as multi-layer perceptron (MLP), Bayesian regularized (BR) neural networks, generalized feed-forward (GFF) neural networks, classification and regression tree (CART), and random forest (RF) were weighted based on JS and the new results were then generated. Eventually, the result of WAE-JS was compared to other models, including MLP, BR, GFF, CART, and RF, based on some statistical parameters, such as R-squared coefficients, RMSE, and VAF as indices for evaluating the performance and capability of the proposed model. The results suggested the superiority of the ensemble WAE-JS system over the base models. In addition, the proposed WAE-JS model effectively improved the predicting accuracy achieved from the MLP, BR, GFF, CART, and RF. Furthermore, the sensitivity analysis revealed that the W/G had the most significant impact on the grout’s UCS values.