Recent progress in research in science and technology has been carried out in various combinatory and diverse ways, and the potential dangers associated with research activities are increasing along with research progress. The actual response to these dangers is not managed by laboratory safety law applied to laboratories with high current risk but it is actually managed by other laws and regulations. By doing so, it is urgently necessary to prepare an environment in which safe research activities can be conducted and to prepare rational management strategies for the prevention of safety hazards in laboratories of hazardous substances. Therefore, in this research, we selected two buildings that use the most harmful factors for two universities, 131 Analyzing the current situation and issues through on-site inspection surveys of harmful factors used in laboratories, Based on the situation of general safety management of domestic and foreign campuses, we suggested suggestions through discussion about the chemical substance management system of laboratories on campus in korea. In addition, the laboratory management system based on individual laws and regulations applied to campus laboratories has reached its limits, and laboratory workers who are applying this will have substantial institutional, administrative and conscious aspects We will try to explore 3P (People, Process, Property) capacity building measures to establish solutions. We intend to establish the standard of the site-centric management system to rationally lower the risk in handling harmful factors at university by incorporating the derived final conclusion into the actual research site.