The importanee of physics in the premedical curriculumii has been recognized for many years. In almost all universities one year of general physics is a prerequisite for adcmissioni to a medical school. Beeause of this brief exposure to physics very few of the medical students have an adequate knowledge of the subject. They do not appreciate the importance of physical prinieiples in the study of biological phenomena. This criticism also applies to biology majors. In many universities they imiay complete a degree program without a single course in physics. Modern biophysics is that branch of applied physics which titilizes the principles and techniques of physics for the investigation of biological and medical problems. Introductory courses in biophysics are specially designied for the premedical students and the biology majors. Such a course has been given at: Tulane Universitv for several years anid is recognized as a valuable part of our undergraduate program. There are many possible proceduires and methods of organization for such a course. The time allotted to the course will determine the number and variety of topics developed. We have experiiiented with three types of coursesone, two, or three hours per week, with equivalent semester hours of credit. The one-hour course has been the most popullar, possibly because it is easy to schedule in an already crowded curriculum. However, many of the students have requested the three-hour course. Topical outlines for both one-hour and threehour courses are appended to this article. Both are based on fifteen-week semesters. The course (either onie-hour or threehour) is opened with a discussion of X-rays. These may or may not have been menitioned in the general physics course, but are famiiiliar to the student. Topics treated inielude the nature and production of X-rays, absorption of X-rars, X-ray scatterinlg-the Compton effect, the effect of X-radiation on living tissue, protectioni from X-radiation, X-ray therapy, initensity measurements aind detection of X-rays. For example. it should be poinited out that studies of the nature of chroiiosom-les and of mutationis caused bX-rays have been of great value in our efforts to understand the livingo plant anid animal cell. The new betatronl aiid syncehrotron as sources of stroioi X-radiationi provide an interesting project for iiivestigation. Natural radioactivity may be correlated with the discussion of X-rays. The .disinteoration of uranium, thorium and actinium, their disintegration products anid the nature of alpha rays, beta rays and goamma radiationl are stressed. Radioactive decav is discussed in terms of half life anid average life values. With this as ani iintroduction a more detailed studv is cenitered around radium anid radonl. The methods of preparation of radiunm and radoii for biological uses, the uniits of miieasuremnent-the curie, millieurie aiid biolog ical roentgen-are introduced. Radium and radon dosage. methods of therapy and tissue reaction to the radiations are but a few of the many biological applications. Method sof producing artificially radioactive materials, such as the Rutherford and Curie-Joliot experiments, are links betweeni cheimistry, biology, and