This paper, guided by the OBE (Outcomes-Based Education) philosophy of "New Agricultural Sciences," oriented by talent cultivation goals, and based on the construction of general chemistry courses in applied universities, elaborates on the construction ideas of general chemistry courses in applied universities. It discusses the diversified construction of general chemistry courses from aspects such as teaching syllabus, teaching model, and assessment methods. Data on students' overall achievement and course goal achievement under different teaching models are analyzed. The results show that the construction of general chemistry courses under the background of "New Agricultural Sciences" has achieved good practical effects.