The purpose of the study is to analyse the peculiarities of using the archives of research and educational institutions as an integral part of the source base of genealogical research on the history of science and technology and to identify the degree of digitalisation of archival collections. The research methodology is based on theoretical developments in history and related sciences, as well as the use of basic approaches to cognition and dialectics, the application of the principles of historical science such as objectivity, scientificity, historicism, universality, systematicity, specificity; the principle of a specific historical approach – historicism – the integrity of the source. The organic blending of general scientific and special research methods in the complex makes it possible to carry out a comprehensive analysis of the topic. The methods of generalisation, analogy, synthesis, analysis, formal logic, as well as historical and chronological, historical and comparative, historical and genetic, historical and typological methods were used in the scientific search, which contributed to obtaining new results in the study of this topic. The scientific novelty of the article is to actualise the issue of using the funds of archives of research and educational centres in conducting genealogical research on the history of science and technology. The systematisation of historiographical sources containing information of genealogical nature is proposed, their information potential is characterised. The reliability degree of the identified sources and the need to introduce new components of the source base of genealogical research on the history of science and technology are determined. The methodological foundations for reconstructing the genealogies of Ukrainian scientists on the basis of representative, diverse sources have been further developed. The necessity of digitalisation of the archival collections of scientific and educational centres, the introduction of information technologies as the main factor in improving the quality of scientific research is substantiated. Keywords: archive, source base, genealogical research, electronic resources, information technology, librarianship, document.