Football is a sports that the most attention and love from many countries and people regardless of gender around the world. Recently, FIFA (Fédération internationale de football association) has been actively helping female football players around the world with economic and technical support. In addition, FIFA has been making great efforts to revitalize the women's league. In this article, the medical issues that should be considered and examined by team doctors and medical teams and what problems should be particularly concerned in female football players will be divided into three categories to be gone through: sports injury, RED-s(relative energy deficiency in sports) and gender verification. First of all, it is known that the overall percentage of injury for female football players is lower than that of male players, however the rate of serious damage is higher in female football players due to the more frequent the knee anterior cruciate ligament injury and traumatic brain injury. It is important to know that RED-s starts with low energy availability as it progresses it can be a serious problem that deteriorates the health and performance of individual athletes. The issue of gender verification is needed to determine whether this player can participate in the women's competition, and it should be check whether this violates the spirit of fair play.