Gender-related Changes Research Articles

Age and Gender Related Changes on Total Antioxidant/Oxidant Status and Electrolyte Composition of Saliva in Individuals

BackgroundSaliva is used as an important biological material in the diagnosis and treatment of various diseases to collect easily, to be cheap, to have a minimal risk of infection. Here in that study we aimed to evaluate age and gender-related changes on total antioxidant/oxidant status and electrolyte composition of saliva levels in individuals. MethodsA total of 30 young adult (21.2± 2.47 years) and 14 adult (51.6±9.35 years) subjects were included in the study. Stimulated saliva samples were collected. Cortisol, amylase, oxidative stress biomarkers (total antioxidant status and total oxidant status) were measured by ELISA and spectrophotometric manual methods and electrolyte level of saliva samples were determined by autoanalyzer. ResultsSalivary concentrations of biomarkers of young adults were compared to adult subjects, there was a statistically significant difference between cortisol (μg/dL) (p=0.003), Ca+2(mg/dL) (p=0.004), TAS (mmol Trolox Equiv/L) (p=0.001), BUN (mg/dL) (p=0.02), Mg+2 (mg/dL) (p=0.02), and K+ (mmol/L) (p=0.05) levels , but there was no significant difference was found between uric acid (mg/dL) (p=0.44), Cl- (mmol/L) (p=0.07), amylase (ng/mL) (p=0.47), phosphate (mg/dL) (p=0.63), Na+(mmol/L)( p=0.21), and TOS (μmol H2O2 Equiv/L) ( p=0.70) levels. We evaluated salivary cortisol, amylase, and electrolyte levels of groups that we commented on their relationship between oxidant-antioxidant defense systems of the saliva and their correlations with age and gender. ConclusionsThis study could suggest the use of saliva samples to correlate with age and representing the levels of the most common biological parameters for routine use and antioxidant-oxidant enzymes for clinical trials.

Defining of the nasal anthropometry on facial computed tomography in subjects with epilepsy and healthy subjects.

Epilepsy is a frequent chronic and genetic brain disease. In diagnose of genetic and craniofacial disease, the face is one of the gold standard phenotypic features. This study was carried out to determine the angle and linear measurements of face region in Turkish healthy and epilepsy subjects, and to apply a feature selection method to identify the most important attributes that affect epilepsy decision. The retrospective and observational study was conducted with 120 subjects with epilepsy aged between 18 to 60 years (56 males; 64 females) and 60 healthy subjects aged between 18 and 55 years (29 males, 31 females). Pyramidal angle performed from 3 reference points, nasal bone length, the width of piriform aperture, nasofrontal angle, nasolabial angle, distance between glabella and nasion were measured on computed tomography. Also, we used supervised machine learning to learn classification models to detect epilepsy as our dataset has class label where 1 means epilepsy, 2 means healthy. The well-known classification model learning algorithms implemented in Weka (with version 3.8.6) machine learning toolkit were applied. All parameters excluding nasal bone length were higher in epilepsy patients than in healthy subjects. Also, there was a significant difference in nasal pyramidal angle nasal bone, nasal pyramidal angle nasal tip, piriform aperture, and nasal bone lengths between epilepsy and healthy subjects. However, age related changes for healthy subjects were no seen in healthy subjects. In epilepsy subjects there was a significant difference in 6 measurements all nasal pyramidal angles, piriform aperture width, nasofrontal angle, and nasolabial angle. Gender related changes were found in only nasal pyramidal angle nasal root and nasal bone of healthy subjects, in nasal pyramidal angle nasal bone, nasal bone length, nasofrontal angle of epilepsy subjects. We can say epilepsy may affect the some facial parameters and these, although anthropometric measurements are affected by age and gender parameters. Comprehensive knowledge of this region's normal references ranges is essential for planning, proper selection of silicone implants or osteotomy determining the limitations of the surgical field and minimizing the risk of complication and performing aesthetic facial surgery or rhinoplasty in epilepsy patients.

Prevalence and Association of Risk Factors According to Liver Steatosis and Fibrosis Stages among Nonalcoholic Fatty Liver Disease Patients with Type 2 Diabetes Mellitus in India: A Cross-sectional Study.

Type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD) are linked to the global diabetes epidemic, leading to increased disease progression and adverse health outcomes. The renaming of NAFLD to metabolic dysfunction-associated steatotic liver disease (MASLD) at the 2023 European Association for the Study of the Liver Congress highlights the complex relationship between metabolic disorders and liver health. Taking this into consideration, we aimed this study to identify prevalence and risk factors associated with the stages of NAFLD in individuals with T2DM in the Indian population. This observational, cross-sectional study was conducted on 1,521 T2DM patients at Dr Panikar's Speciality Care Centre, Mumbai, between September 1, 2022 and October 31, 2022. Demographic parameters such as age, gender, height, weight, and anthropometric parameters such as body mass index (BMI) and waist circumference were measured. Liver fibrosis and steatosis stages were identified by vibration-controlled transient elastography (VCTE) using FibroScan®. The prevalence of liver steatosis was 75.1% among the 1,521 diabetes cases [S0 (24.9%), S1 (15.1%), S2 (24%), and S3 (36%)], whereas the prevalence of liver fibrosis was 28.0% [F0 (72%), F1 (19%), F2 (5%), F3 (1.5%), and F4 (3.4%)]. The S1 (p = 0.012), S3 (p = 0.001), F1 (p = 0.001), and F2 (p = 0.001) grades showed significant gender-related changes, demonstrating a positive connection. Furthermore, waist circumference was associated with disease severity in both liver steatosis and fibrosis stages (p = 0.001), but BMI was solely associated with the degree of steatosis (p = 0.001). The mean age differences between these categories, however, did not reach statistical significance (p-values of 0.149 and 0.078, respectively, for the steatosis and fibrosis grades). The study reveals a high prevalence of NAFLD (steatosis and fibrosis) in T2DM patients, increasing the risk of advanced fibrosis. In T2DM patients with risk factors including waist circumference and BMI, appropriate screening and intervention are required.

Evaluating age-and gender-related changes in brain volumes in normal adult using synthetic magnetic resonance imaging.

Normal aging is associated with brain volume change, and brain segmentation can be performed within an acceptable scan time using synthetic magnetic resonance imaging (MRI). This study aimed to investigate the brain volume changes in healthy adult according to age and gender, and provide age- and gender-specific reference values using synthetic MRI. A total of 300 healthy adults (141 males, median age 48; 159 females, median age 50) were underwent synthetic MRI on 3.0 T. Brain parenchymal volume (BPV), gray matter volume (GMV), white matter volume (WMV), myelin volume (MYV), and cerebrospinal fluid volume (CSFV) were calculated using synthetic MRI software. These volumes were normalized by intracranial volume to normalized GMV (nGMV), normalized WMV (nWMV), normalized MYV (nMYV), normalized BPV (nBPV), and normalized CSFV (nCSFV). The normalized brain volumes were plotted against age in both males and females, and a curve fitting model that best explained the age dependence of brain volume was identified. The normalized brain volumes were compared between different age and gender groups. The approximate curves of nGMV, nWMV, nCSFV, nBPV, and nMYV were best fitted by quadratic curves. The nBPV decreased monotonously through all ages in both males and females, while the changes of nCSFV showed the opposite trend. The nWMV and nMYV in both males and females increased gradually and then decrease with age. In early adulthood (20s), nWMV and nMYV in males were lower and peaked later than that in females (p<.005). The nGMV in both males and females decreased in the early adulthood until the 30s and then remains stable. A significant decline in nWMV, nBPV, and nMYV was noted in the 60s (Turkey test, p<.05). Our study provides age- and gender-specific reference values of brain volumes using synthetic MRI, which could be objective tools for discriminating brain disorders from healthy brains.

Sex-Related Glycemic and Cardiovascular Responses After Continuous and Interval Aerobic Sessions in Patients With Type 1 Diabetes: A Randomized Crossover Study

We aimed to investigate sex-related glycemic and cardiovascular responses after intensity- (moderate) and duration- (30 minutes) matched interval aerobic exercise (IAE) and continuous (CAE) aerobic exercise sessions in patients with type 1 diabetes mellitus (T1DM). A total of 19 volunteers (10 women) participated in 2 randomized and crossover sessions (1:1). Heart rate, systolic and diastolic blood pressure, double product, and blood glucose (BG) levels were measured before (PRE), immediately after (POST-0), and 20 minutes after (POST-20) each session. The rates of perceived exertion (RPE) and enjoyment levels (ELs) were assessed after each session. Generalized estimating equations were used to analyze the data (condition × time × sex). Regarding sex-related changes, men showed BG reductions at POST-0 and POST-20 after CAE (∆: -3.7 and -3.7 mmol/L, respectively) and only at POST-0 after IAE (∆: -1.6 mmol/L), with 1 episode of hypoglycemia occurring in the latter group. In contrast, women showed reduced BG values only after CAE at both time points (∆: -1.4 and -1.7 mmol/L) compared with PRE values. The decrease in BG levels at both time points was higher for men after CAE than IAE. Cardiovascular responses, RPEs, and ELs were similar between exercise sessions, except for blood pressure, which showed higher values in men. In conclusion, lower BG levels were observed after CAE, with greater reductions in men. Similar cardiovascular, RPE, and EL responses were found across sexes and sessions. Consideration of sex-specific recommendations may be warranted when prescribing aerobic exercise, particularly, for men with irregular physical activity levels.

Examination of Age and Gender-Related Changes in Spinopelvic Parameters in Children and Adolescents Using Computed Tomography Images

Aim: In order for a person to stand in a balanced way, the pelvis and spine must be in harmony. The aim of this study was to determine the normal ranges of spinopelvic parameters in children and adolescents in Türkiye. Material and Method: In our study, computed tomography images of 1018 healthy 7-17 year olds were examined. As a result of this examination, sacrum pubic incidence, lumbar lordosis, sacral slope, sacral kyphosis, pelvic tilt and pelvic incidence were measured. Results: The sacrum pubic incidence was 58.71±6.17°, sacral slope 37.26±5.77, lumbar lordosis 42.98±8.06°, sacral kyphosis 21.27±9.96°, pelvic incidence 46.77±6.38, and pelvic tilt 9.51±5.06°. The calculations revealed that, with age, all parameters except pelvic tilt increased significantly. A statistically significant difference was found between the age groups. Conclusion: The results of this study will contribute to the existing literature and may give clinicians insight into sagittal corrections in spine and pelvic surgery.

Airway Analysis in Different Malocclusions - A Cephalometric Study

Background: It was essential to evaluate respiratory function when diagnosing and planning orthodontic treatment. Based on the correlation between pharyngeal airway space and craniofacial structure, airway width was hypothesized to be an indicator of airway patency in different groups of skeletal malocclusion. Aim: The purpose of this study was to investigate age and gender related changes in pharyngeal airway dimensions in different sagittal skeletal relationships Materials and Method: Sixty lateral cephalograms of patients aged 10-30 years with no pharyngeal pathology or nasal obstruction were retrospectively selected and categorized into skeletal Class I (n = 20), Class II (n = 20), and Class III (n = 20) malocclusion based on ANB angle. McNamara's airway analysis was used to quantify upper- and lower-airway dimensions. The analyses of intergroup differences were performed using a one-way ANOVA, an independent t-test, and Tukey's test as a post-hoc test. Results: Participants in the study ranged in age from 20.57 ± 5.41 years (males) and 20.03 ± 4.58 years (females) were included in the study. The upper pharyngeal airway (UPA) dimensions demonstrated a positive correlation with age. In both genders, the mean upper pharyngeal airway (UPA) size exceeded the lower pharyngeal airway (LPA) size, but neither age nor gender was associated with statistically significant differences in skeletal malocclusion. Conclusion: It was shown that skeletal malocclusions of different types have no effect on the upper and lower pharyngeal airways and that the upper and lower pharyngeal airways are not influenced by age or gender.

Role of Magnetic Resonance Imaging in the Evaluation of Age- and Gender-Related Changes in the Dimensions of the Pituitary Gland in the Indian Population.

Background MRI is the standard tool for imaging the pituitary gland. MRI is useful in detecting pathological conditions in the pituitary. Changes in the size and shape of the pituitary among different age groups are seen in MRI. Linear growth is seen in the pituitary during puberty except for growth spurts at the 1st, 10th, and 15th years, followed by a decline in pituitary height and cross-sectional area with increasing age. A convex upper margin was seen in females more than in males. There is a shortage of information about pituitary dimensions and volume in various age groups and among both genders in the Indian population. Hence, a study is needed to assess these parameters. Materials and methods A retrospective cross-sectional study was done in the MRI unit of Radiology, Saveetha Medical College and Hospital, Chennai. A total of 200 patients in the age group of 11-80 years who underwent MRI free from neuroendocrine, neurological, and psychiatric disorders were included in this study. Statistical analysis Measurements were made of the pituitary gland's height, volume, and anteroposterior and transverse dimensions. Using SPSS Statistics software (IBM Corp. IBM SPSS Statistics for Windows. Armonk, NY: IBM Corp.), the data was input and examined. The ANOVA test revealed the relationship between anteroposterior dimension, transverse dimension, height, and volume with age. In contrast, an independent t-test determined the association of the same parameters with sex. The Chi-square test was used to assess the association of the shape of the pituitary gland with age and sex. Results Anteroposterior dimension, height, and volume of the pituitary gland were found to be statistically significant with age (p<0.05), but the transverse dimension was not significant with age (p>0.05). However, the independent t-test showed highly significant differences between the anteroposterior dimension in males and females. The shape of the pituitary gland was found to be statistically significant with age and gender. In contrast, the pituitary gland's transverse diameter, height, and volume showed no significance. Conclusion The study helps identify the substantial changes in the pituitary gland during a person's lifespan, which are affected by age and gender. The pituitary height and volume will reflect physiological neuroendocrine differences between younger and older male and female subjects.

Age- and gender-related changes in diameter of the lumbar spinal canal: A cross- sectional analysis of 2220 patients with low back pain

Age- and gender-related changes in diameter of the lumbar spinal canal: A cross- sectional analysis of 2220 patients with low back pain

THE EFFECT OF CHRONOLOGICAL AGE AND GENDER AND DIFFERENT SOURCE OF TISSUE ON THE IN VITRO PROPERTIES OF MESENCHYMAL STROMAL CELLS

AbstractObjectivesOsteoarthritis is a common articular cartilage disorder and causes a significant global disease burden. Articular cartilage has a limited capacity of repair and there is increasing interest in the use of cell-based therapies to facilitate repair including the use of Mesenchymal Stromal Cells (MSCs). There is some evidence in the literature that suggests that advancing age and gender is associated with declining MSC function, including reduced proliferation and differentiation potential, and greater cellular apoptosis. In our study, we first performed a systematic review of the literature to determine the effects of chronological age and gender on the in vitro properties of MSCs, and then performed a laboratory study to investigate these properties.Methods and ResultsWe initially conducted a PRISMA systematic review of the literature to review the evidence base for the effects of chronological age and gender on the in vitro properties of MSCs including cell numbers, expansion, cell surface characterization and differentiation potential. This was followed by laboratory-based experiments to assess these properties. Compare the extent of the effect of age on MSC cell marker expression, proliferation and pathways. Tissue from patients undergoing total knee replacement surgery was used to isolate MSCs from the synovium, fat pad and bone fragments using a method developed in our laboratory. The growth kinetics was determined by calculating the population doublings per day. Following expansion in culture, MSCs at P2 were characterised for a panel of cell surface markers using flow cytometry. The cells were positive for CD73, CD90 and CD105, and negative for antibody cocktail (eg included CD34, CD45). The differentiation potential of the MSCs was assessed through tri-lineage differentiation assays. At P2 after extracting RNA, we investigate the gene analysis using Bulk seq. Clear differences between the younger and older patients and gender were indicated.ConclusionsChronological age and gender-related changes in MSC function have important implications on the use of these cells in clinical applications for an ageing population. The results from this study will be used to plan further work looking at the effects of chronological age and gender on cellular senescence and identify pathways that could be targeted to potentially reverse any age and gender-related changes.Declaration of Interest(b) declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported:I declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

A framework based on the information domain to measure coupling changes in electrophysiological signals

Objectives. In this paper, the features of physiological signals of healthy dataset are extracted using the linear and non-linear techniques, and a comparison has been made on healthy young and old subjects to study the aging and gender-related changes in the contribution of Heart Rate (HR), Blood Pressure (BP), and Respiration (RESP). Methods. To quantify the coupling changes in cardiovascular, cardiorespiratory, and vasculorespiratory complexity, an information domain approach based on compensated transfer entropy (cTE) is proposed. Result. The results show that there is a substantial decrease in the flow of information from BP tro the time interval between successive R-peaks (RR) and from RR to BP. There is also a significant decrease in the flow of information from RESP to BP and RESP to RR but there is no significant change in the information flow from BP to RESP and RR to RESP. Conclusion. We have done linear and non-linear analysis on the healthy datasets of young and old subjects. As already existed techniques lacks in studying complex behaviours of electrophysiological signals so to overcome these limitations, we have proposed compensated transfer entropy (cTE). We conducted an investigation to determine the degree to which recordings of RESP, BP, and HR can be utilized to predict changes in the other parameters. Specifically, the proposed analysis examined the relationship between these variables and assessed their consistency across different age groups and genders. By analyzing the data, we aimed to gain insights into the interdependencies and predictive potential of these physiological measures in relation to each other.

Anatomical and radiological evaluation of frontal lobe morphometry in healthy and dementia people and machine learning-based prediction of dementia

Purpose: This paper aimed to determine the morphometry of the frontal lobe and central brain region using magnetic resonance imaging in patients having dementia and healthy subjects. &#x0D; Materials and Methods: 243 subjects (121 subjects having dementia; 122 subjects healthy group) aged 60-90 years over for 2 years between January 2018 and 2020 were included in this study. Also, the supervised Machine learning based (ML based) detection of dementia has been studied on this obtained real world data.&#x0D; Results: The gender-related changes of frontal region measurements in dementia and healthy subjects were analyzed and, there were differences of measurements’ mean values in gender. In healthy subjects, significance differences were found in all measurements (except the distance from anterior commissure to posterior commissure and outermost of corpus callosum genu to innermost of corpus callosum genu). The means of the measurements were found higher in males than in females.&#x0D; Conclusions: We believe that the knowledge of our study will provide valuable reference data for our population and will help for a surgeon in planning an operation by considering measurements related to the frontal lobe. In addition, ML based supervised methods that were trained on the collected data for detection of dementia showed that it is required to provide as many attributes and instances as possible to train an accurate estimator. However, if this is not possible, by creating new features based on the hidden patterns between attributes and instances we could increase the success of the estimators up to 96.3% f-score value.

To estimate age and gender related morphometric changes in lateral ventricle of brain by Evans index in north Indian population

Introduction: Several histopathological and gross changes are seen in human brain as age increases, causing enlargement of the lateral ventricles. Morphometric measurement and ventricular size of lateral ventricle is of trivial importance to identify certain changes and correlate it with clinical significance. This study is designed to provide a normal data of Evans Index of lateral ventricle of brain and its association between both the genders and its correlation with different age group of North Indian Population. Materials and methods: This study was carried out in the Department of Anatomy &amp; Department of Radiodiagnosis, S.N Medical College, Agra, U.P. In this prospective study, Computed Tomography Scans of 200 patients between the age 18 – 75 years (120 Males and 80 Females) were done and measurements of lateral ventricle of Brain and were analyzed statistically. Results: The overall mean value of Evans Index is 0.23 ± 0.02. Evans Index in males is 0.23 ± 0.02 and mean Evans Index in females is 0.22 ± 0.01, the difference being statistically significant between both the genders as p = 0.0001* (p ≤ 0.05). Conclusions: Evans Index is a widely and most commonly used linear measurement for the determination of ventricular dilation which is helpful in diagnosis of neurological conditions (e.g.schizophrenia, bipolar disorder and Non Pressure Hydrocephalus). If the Evans Index ranges from 0.25 to 0.30 represented early ventricular enlargement and if the Evans Index value is more than 0.30, it suggests Hydrocephalus. Keywords: Lateral Ventricle, Brain, Morphometry, Ventricular system, CT, Evans Index

Age and Gender Specific Effect of Lip Form on Maxillary and Mandibular Incisal Display with Lips at Rest in Elderly Indian Population: A Cross-sectional Study

Introduction: Maxillary and mandibular incisal display at rest and smile is an integral part of dento-facial aesthetics. Its correlation with lip form and the effect of age and gender has not been studied in elderly Indian population. Dental photography has been given a great importance in prosthodontics and the study of various aesthetic parameters on digitalised photographs can act as additional diagnostic tool. Aim: To determine correlation between lip form and incisal display in elderly subjects and to determine age and gender related changes. Materials and Methods: A cross-sectional study was conducted in the Department of Prosthodontics, Karnavati School of Dentistry, Gandhinagar, Gujarat, India, from November 2020 to September 2021. The study sample comprised of digital photographs taken in natural head position of 324 elderly Indian subjects (180 males &amp;144 females) and they were divided into 4 age groups: Group I consisting of 157 subjects aged (31- 45 years), Group II consisting of 107 subjects aged (46-55 years), Group III consisting of 47 subjects aged (56-65 years) and Group IV consisting of 13 subjects aged &gt;65 years. The various parameters (lip form, maxillary and mandibular incisal display) were then analysed using Image J (Fiji app) image analysis software. The statistical analysis was done using Pearson correlation (significant when p&lt;0.05), scatter plot, and Independent t-test (significant when p&lt;0.05) and one-way Analysis Of Variance (ANOVA) post-hoc Tukey-Kramer test to compare the parameters of different groups. Results: The results of this study showed that there is a significant correlation between lip form and maxillary &amp; mandibular incisal display at rest (r=0.388, p=0.001). Females have more incisal display for a particular type of lip form as compared to male subjects. A statistically significant difference was found in maxillary incisal display and lip form between male and female groups (T=-5.934, p-value=0.001 and T=-2.367, p-value=0.019 respectively) but no statistically significant difference was found in mandibular incisor display between male and female groups (T=1.832, p-value=0.068). Hence, females above 30 years of age had more maxillary incisal display as compared to males but almost same mandibular incisal display. Also, straight lip form was more common among elderly male subjects (63.6% as compared to females 36.4%) but females had moderate lip form most commonly (52.1% as compared to males 47.9%). High lip form was reported equally in both male and female subjects with 50% in each group. Conclusion: It has been concluded from the study that for a particular type of lip form (either straight, moderate or high), females have more average incisal displays as compared to males. A strong correlation exists between lip form and incisal display in elderly Indian population. Hence, lip form can be used as a definitive parameter to determine Incisal displays in prosthetic rehabilitation to get optimum aesthetic outcomes.

Linguistic means of reflecting gender-related changes in modern society (exemplified by English-language newspapers advertisements)

Language means play a crucial role in the shaping stereotypes within cultural groups. The present study addresses the issues of gender neutralization in English-language advertising and newspaper texts. The paper investigates linguistic means involved in the creation of genderneutral advertising texts. The analysis of gender-unmarked advertising texts was conducted on the material of English-language newspaper texts from the rubrics "Lifestyle", "Health", "Sports", "Culture" of The Guardian edition. As a result of the study, the authors conclude that the main features of gender-neutral advertising texts are the absence of lexical units that would refer advertising to male or female; the use of scientific terms, numbers in the description of the goods; the use of imperative sentences. Gender neutralization in advertising occurs due to the use of impersonal sentences, defining pronouns and euphemisms. Gender neutralization is a relatively new trend in advertising and has a huge impact on the use of language in modern advertising texts.

Morphometric Analysis of Age and Genderrelated Variations of Corpus Callosum by using Magnetic Resonance Imaging: A Cross-sectional Study

Introduction: The Corpus Callosum (CC) is the largest commissural bundle connecting the two cerebral hemispheres which is involved in learning, memory, thinking, three-dimensional visual ability, executive functions as well as behavioural patterns. Exact morphometric dimensions are a prerequisite before surgical interventions and stereotactic approaches to the foramen of Munro and also in cases of callosectomy for intractable epilepsy as inconsistencies exist regarding gender and age related changes of CC. Also, most published studies are from the western world and very few studies are from South-east Asia and India. Aim: To study the morphometry of CC and possible age, gender related variations using Magnetic Resonance Imaging (MRI) in the North Indian population. Materials and Methods: An observational, cross-sectional study was done in Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India from January 2019 to October 2019. A total of 200 head MRI scans, using PACS (Picture Archiving and Communication System) System Viewer software were evaluated. In all the scans, length, height, minimum and maximum thickness of CC were studied. The data were statistically analysed using STATA Software for age and gender-related differences. Student’s t-test, one-way Analysis of Variance (ANOVA), linear regression and Pearson correlation coefficient were applied. Results: The study showed decrease in thickness of body, rostrum and splenium with age, linked to generalised degeneration of cortical neurons or atrophy of white matter with advancing age. Also, there was increase in length with age, possibly due to age mediated structural dilatation in lateral ventricles. Statistically significant sexual dimorphism was observed as a larger CC length in males (74.24±4.26 mm) than females (72.67±4.16 mm) (p-value&lt;0.001) and larger brain length in males (171.75±5.51 mm) as compared to females (163.70±5.75 mm) (p-value&lt;0.001). Males also showed greater splenial thickness (10.15±1.79 mm) in comparison to females (9.68±1.51 mm) (p-value&lt;0.001) which may represent the importance of distribution of fibres of visual cortex in males due to larger occipital lobe. Conclusion: The present study documented morphometry of normal CC in different gender and age groups and observed sexual dimorphism, especially greater CC length and splenial thickness in males than females. With age increase in the length and decrease in thickness of CC was seen.

Institution and gender-related differences in publication speed before and during COVID-19.

The COVID-19 pandemic elicited a substantial hike in journal submissions and a global push to get medical evidence quickly through the review process. Editorial decisions and peer-assessments were made under intensified time constraints, which may have amplified social disparities in the outcomes of peer-reviewing, especially for COVID-19 related research. This study quantifies the differential impact of the pandemic on the duration of the peer-review process for women and men and for scientists at different strata of the institutional-prestige hierarchy. Using mixed-effects regression models with observations clustered at the journal level, we analysed newly available data on the submission and acceptance dates of 78,085 medical research articles published in 2019 and 2020. We found that institution-related disparities in the average time from manuscript submission to acceptance increased marginally in 2020, although half of the observed change was driven by speedy reviews of COVID-19 research. For COVID-19 papers, we found more substantial institution-related disparities in review times in favour of authors from highly-ranked institutions. Descriptive survival plots also indicated that scientists with prestigious affiliations benefitted more from fast-track peer reviewing than did colleagues from less reputed institutions. This difference was more pronounced for journals with a single-blind review procedure compared to journals with a double-blind review procedure. Gender-related changes in the duration of the peer-review process were small and inconsistent, although we observed a minor difference in the average review time of COVID-19 papers first authored by women and men.

Prediction of gender from longitudinal MRI data via deep learning on adolescent data reveals unique patterns associated with brain structure and change over a two-year period

Deep learning algorithms for predicting neuroimaging data have shown considerable promise in various applications. Prior work has demonstrated that deep learning models that take advantage of the data's 3D structure can outperform standard machine learning on several learning tasks. However, most prior research in this area has focused on neuroimaging data from adults. Within the Adolescent Brain and Cognitive Development (ABCD) dataset, a large longitudinal development study, we examine structural MRI data to predict gender and identify gender-related changes in brain structure. Results demonstrate that gender prediction accuracy is exceptionally high (>97%) with training epochs > 200 and that this accuracy increases with age. Brain regions identified as the most discriminative in the task under study include predominantly frontal areas and the temporal lobe. When evaluating gender predictive changes specific to a two-year increase in age, a broader set of visual, cingulate, and insular regions are revealed. Our findings show a robust gender-related structural brain change pattern, even over a small age range. This suggests that it might be possible to study how the brain changes during adolescence by looking at how these changes are related to different behavioral and environmental factors.

A study of morphological changes in the mandible associated with sexual dimorphism: a digital panoramic study

BACKGROUND: In forensic anthropology, osteological remains are widely used to assess various characteristics of a person, which helps in establishing the identity of the deceased or serves as additional evidence in controversial cases.&#x0D; AIMS: The study aimed to measure, compare and distinguish the gender-related changes in the mandible among dentate of different age groups on digital panoramic radiographic images and to evaluate their reliability in sex determination that might serve as evidence in forensics.&#x0D; MATERIALS AND METHODS: Digital panoramic images were obtained for 420 patients, which included 210 males and 210 females. Various parameters such as gonial angle, condylar length, ramus length, cortical bone thickness and ramal notch width were measured and evaluated. The data obtained was subjected to descriptive statistical analysis and two-way ANOVA test.&#x0D; RESULTS: Comparison between gender groups showed statistically significant differences in all parameters with p 0.05 except the ramal notch width. The mean value of all parameters, was found to be comparatively higher in males. Among the groups, gonial angle and ramus length were found to be higher on right side, but in ramal notch width it was higher on left. The condylar length among males showed greater value on right side, and females showed greater value on left side. The cortical bone thickness among males depicted greater value on left side, and females depicted greater value on right side. Thus, all parameters except the ramal notch width were found to be reliable in sex determination.&#x0D; CONCLUSION: It was found that males had greater value when compared to females. Hence, this study recommends the use of these parameters for the purpose of sex determination.

Osteoarthritis induces gender-related changes in the knee range of motion.

In time, osteoarthritis (OA) generates the misalignment of the affected joint structures. However, due to the nature of bipedal gait, OA in the lower limb can also cause pathological gait patterns, which can generate instability and falls, with great consequence, especially in the aged population. With goniometry used to evaluate the range of motion (ROM) of joints, we wanted to evaluate how gender impacts gait dynamics in OA patients. For this study, we have compared 106 OA patients (74 females and 32 males) to age matched controls. All participants had their right leg as dominant. Video recording of normal gait was analyzed with a digital goniometry tool phone application, and the knee's ROM was measured in midstance and midswing moment of the gait. During midstance, significant extension and flexion of the knee excursion have been observed in both males and females. During midswing, knee OA presents more differences, whereas subjects with hip and knee OA present changes on the dominant knee. Midstance changes suggest that the knee's joint degenerative changes, such as synovitis, can be linked to hip OA secondary changes. Midswing changes in lower limb OA suggest a connection to the activities of daily life. Gender differences generated by OA must furthermore be studied in both lower limbs so that the best therapeutic approach can be chosen.