BackgroundThe differences in anatomical structure between men and women are widely known. Unfortunately, the influence of gender on the biomechanics of a healthy knee joint during gait is still poorly understood. Research questionThe aim of the presented study was to determine loads acting in the knee joint during gait, based on the observation of a large group of healthy young adults, in particular to determine the influence of gender on values of forces and moments and their time characteristics during gait cycle. MethodsTime-spatial gait parameters and ground reaction force were registered for 86 persons (43 females and 43 males) using a motion capture system and force plates. The numerical simulation with the AnyBody system was used to estimate loadings acting in the knee joint. Differences between women and men were tested using the unpaired Student's t-test with a Bonferroni correction. ResultsThe maximum values of loadings acting in the knee joint were: 411.1 %BW (body weight) for resultant force, 390.6 %BW for proximo-distal force, 110.8 %BW for antero-posterior force, 77.0 %BW for medio-lateral force, 2.63 %BWh (body weight times height) for flexion/extension moment, 0.97 %BWh for internal/external rotation moment and 5.7 %BWh for abduction/adduction moment. In general, the normalised forces were greater in the male group, while the normalised external moments acting on the knee were greater in the female group. Local extrema of forces during the stance phase were observed earlier for women. SignificanceKnowledge about gender differences in loadings acting in the knee joint can be of great importance in the case of detecting the early stages of gait abnormalities and treatment planning.