The article is dedicated to the issue of the United Nations activities in preventing and eradicating gender-based crimes. It is indicated that gender-based violence and gender-motivated killings can be classified as hate crimes motivated by intolerance towards certain groups of the population. It is noted that an important contribution to combating gender-based crimes was made by the General Assembly, the Secretary-General, the UN Office on Drugs and Crime, the Committee on the Elimination of Discrimination against Women, the Special Rapporteur on violence against women and girls, its causes and consequences, and other bodies, institutions and structures of the Organization. In particular, the UN General Assembly has adopted a number of resolutions in this area, including Resolution 68/191, which set out recommendations to Member States and UN bodies, agencies and institutions on measures against gender-related killing of women and girls. In pursuance of this recommendation, an open-ended intergovernmental expert group meeting was convened to review promising practices and formulate a number of practical recommendations on ways and measures to improve the effectiveness of efforts to prevent and investigate gender-related killings. It is indicated that since 2019, UNODC has been implementing the Global Programme on Strengthening Crime Prevention and Criminal Justice Responses to Violence against Women, providing specific solutions that complement existing UN joint programmes and country projects. It is noted that the Committee on the Elimination of Discrimination against Women has played an important role in combating gender-based crimes. In particular, in its concluding observations on the periodic reports of States parties and in the context of relevant follow-up procedures, the Committee consistently condemns gender-based violence. In addition, the Committee provides clarification of the standards related to the elimination of such violence and the related obligations of States parties. The article also focuses on the work of the Special Rapporteur on violence against women and girls, its causes and consequences in this area.