Gel State Research Articles

Ultrafast synthesis and binder‐free fabrication of a monolithic metal–organic framework for efficient carbon capture

AbstractAchieving rapid synthesis alongside efficient shaping without sacrificing high porosity and crystallinity poses significant challenges for metal–organic frameworks (MOFs) in practical applications. Here, we report an ultrafast, scalable method for preparing an ultramicroporous MOF at room temperature. This method achieves a space–time yield significantly higher than conventional MOF synthesis by orders of magnitude. As a result of strongly promoted crystal nucleation by careful selection of solvent and metal source, the MOF material is produced in a gel state offering both high crystallinity and processability. This allows for the binder‐free fabrication of monolithic adsorbents with predesigned macro shapes and sizes. Owing to its narrowly distributed pore size and high‐density open metal sites, the monolithic adsorbent demonstrates top‐tier selectivity for CO2/N2 (>200) and CO2/CH4 separations. The performance sets a new benchmark among current MOF xero‐ or aerogel monoliths. Breakthrough experiments further verify its robust ability for carbon capture under dynamic conditions.

Binder-Mediated Supramolecular Polymerization with Controllable Gel-to-Crystal Transformation in Metal-Organic Polyhedra.

Controlling supramolecular polymerization across various length scales through metal-organic polyhedra in aqueous media enables functional nanomaterial fabrication beyond traditional π-chromophoric systems. Herein, we present a straightforward strategy to tune the nano- and microscopic structural evolution of a co-assembled system. Ga-MOC ([Ga8(ImDC)12]12-, ImDC = imidazoledicarboxylate) is introduced as a discrete unit, while the Ni-ethylenediamine complex [Ni(en)3]2+ (Ni-en), served as the binder towards supramolecular polymerization. Comprehensive investigations revealed that adjusting the binder ratio in the bicomponent (Ga-MOC and Ni-en) co-assembly process allows precise control over nanostructure length and evolution by influencing both the kinetics and thermodynamics of the assembly. At higher concentrations, this assembly forms a hydrogel above a critical binder ratio. Furthermore, the binder's ratio significantly influences the viscoelastic strength of the hydrogels by modulating the connectivity between the MOCs through hydrogen (H)-bonding. Intriguingly, the hydrogels gradually transformed into crystals without any external stimuli, with different timescales regulated by the binder ratio. Single crystal structure determination reveals a 3D structure composed of Ga-MOC and Ni-en, extended through charge-assisted H-bonding (CAHB) interactions, resulting through the transformation from a kinetically controlled gel state to a thermodynamically stable crystal product. This study provides an understanding of binder-mediated control over nanostructural evolution in co-assembled MOCs.

Licochalcone A loaded multifunctional chitosan hyaluronic acid hydrogel with antibacterial and inflammatory regulating effects to promote wound healing

The wound healing process is characterized by persistent infection and long-term inflammation. The licochalcone A (LicA) has the potential for skin wound healing and needs a good drug-loading platform to apply its antibacterial and anti-inflammatory effects. In this study, the LicA@chitosan (CS) -hyaluronic acid (HA) hydrogel with antibacterial and anti-inflammatory was developed for wound healing in mice. The SEM displayed that the hydrogel had an obvious porous structure and was very suitable to be used as a delivery carrier for LicA. The FTIR results suggested that the LicA can be effectively loaded in the CS-HA hydrogel. Variable strain scanning, frequency scanning and temperature scanning indicated that the LicA@CS-HA hydrogel can maintain the gel state. The LicA@CS-HA hydrogel had good biological safety, can inhibit the activity of Escherichia coli and Staphylococcus aureus, and can release LicA stably. The LicA@CS-HA hydrogel also has good adhesion and hemostatic properties. Finally, the LicA@CS-HA hydrogel significantly accelerated wound healing in mice skin injury model, and reduced inflammation and orderly collagen deposition were observed by HE and Masson staining. The immunohistochemistry indicated that the LicA@CS-HA hydrogel induced the positive expression of CD31, VEGF, and HIF-1α promoted neovascularization. The LicA@CS-HA hydrogel also down-regulated the expression of M1 macrophage markers CD86, IL-6, and TNF-α, and increased the expression of M2 macrophage markers CD206, IL-4, and IL-10 proteins. The molecular docking demonstrated that the target proteins had better binding activity to LicA. Collectively, the LicA@CS-HA hydrogel has broad application prospects in promoting wound healing.

Colloidal state-based studies on the chloride salts of magnesium- and calcium-induced coagulation of soymilks.

Chloride salts (MgCl2 and occasionally CaCl2) coagulation of the heated soymilks is the key step in manufacturing traditional tofu. In this study, colloidal state diagrams were constructed first, and then the effects of processing parameters, including coagulant concentration, preheating intensity, protein concentration, and coagulation temperature as well as the intrinsic properties (phytate concentration) on the microstructure, protein coagulability, and water holding capacity (WHC) were investigated to gain an overall framework understanding of the Mg2+ and Ca2+ coagulated soymilk process. As the variables changed, the coagulated soymilks displayed one of the following states: colloidal suspension, flocs, weak gel, and strong gel. The microstructures of the coagulated systems also changed to different features with the variation in processing parameters and phytate concentrations. Several interesting results were obtained. It was found that the transformations from colloidal suspension to gel state were usually corresponding to the increase of particle size, the decrease of porosity, and a sharp increase in protein coagulability. The colloidal states of Mg2+ and Ca2+ coagulated soymilks were usually different, but their microstructures were similar. With the increase of protein concentration, the protein coagulability decreased but the WHC was enhanced. The presence of high phytate contents led to form small protein agglomerates, which resulted in worse protein coagulation and WHC. It is expected that this study will deepen the understanding of chloride salts coagulation process.

Light-Induced Transformation of a Supramolecular Gel to a Stronger Covalent Polymeric Gel.

A polymerizable diacetylene gelator, containing urea and urethane groups, that congeals various non-polar solvents was synthesized. The gelator molecules self-assemble forming non-covalent polymers through intermolecular hydrogen bonding, as evidenced from FT-IR and concentration-dependent 1H NMR spectroscopy. The self-assembly positions the diyne units of adjacent molecules at proximity and in a geometry suitable for their topochemical polymerization. UV irradiation of the gel resulted in topochemical polymerization, transforming the non-covalent polymer to a covalent polymer, in situ, in the gel state. The polymerization was confirmed by characterizing the polydiacetylene (PDA) using UV-Vis and Raman spectroscopy. Time-dependent rheological studies revealed gradual strengthening of the gel with the duration of irradiation, suggesting that the degree of polymerization increases with the duration of irradiation. The PDA formed is a semiconductor, which might be useful for various applications.

Gelation and post-gelation mechanism of methylcellulose in an aqueous medium: 1H NMR and dynamic compressive rheological studies.

Methylcellulose (MC) has become crucial in 3D bioprinting in the last decade. Researchers investigated MC aqueous solutions blended with biopolymers at room temperature, focusing on rheological studies. Even at low concentrations, the gel state of MC, which provides structural strength through hydrophilic and hydrophobic associations, was explored for injection-based 3D printability. Post-gelation phenomena were examined at 80 °C using a dynamic mechanical analyzer (DMA), revealing increased storage and loss moduli with frequency, indicating a robust gel network structure. Optical microscopy reveals that upon heating from 40 to 80 °C, the structural strength is enhanced via the formation of hydrophobic confirmations, starting from the micro-helical structure to the associated microarray. These microarrays are further synchronized to withstand the high frequency of the DMA probe. Compressive rheology outcomes allow us to elaborate on the possibility of injection-based 3D printability of aqueous MC gel at 80 °C. 1H and 13C NMR studies probed hydrophobic interactions among MC chains, showing evidence of H-bonding through temperature-dependent shifts. UV/Vis experiments traced gel formation, depicting a time-dependent network formation process. Overall experiments indicated that adjusting temperature could control gelation time, allowing precise tuning of the printing process and achieving fine layers (10 μm) in the printed membrane with maximum hydrophobic clusters.

Pyridine hydrazide glycoconjugate-based gelators: Facile synthesis and exploring their application in iodide sensing

Detection of iodide (I−) holds great importance because of its crucial role in various biological activities in the human body. However, its selective detection using small molecular systems has not been as well-explored as metal complex and metal-framework structures, which are expensive and difficult to synthesize. Here, we have reported the synthesis of a novel class of 4,6-O-protected sugar-pyridine hydrazide derivatives in an environmentally benign condition with moderate yield. The overall characterization was done using NMR, HRMS, single-crystal XRD, and DFT studies. Anomeric forms of the N-glucosylamines were assigned from NMR spectroscopy and single-crystal XRD studies. The selective sensing ability towards I− of the synthesized derivatives has been confirmed through colourimetry, UV–Vis and 1H NMR titration and gelation studies. The 4,6-O-butylidene derivatives 6(a–c) were utilized because of their better solubility for the selective detection of iodide ion in solution, whereas 4,6-O-benzylidene derivatives 7(a–c) were used for the same in gel state for their enhanced gelation ability. Furthermore, the morphology of the xerogels have been analyzed through SEM and the thermal ability has been determined by DSC spectra. The experimental studies suggest that the iodide anion takes part in self-assembly formation with the sugar-pyridine hydrazide derivatives through C–H···I− interaction, which, along with H-bonding, π–π stacking, van der Waal force of interaction enhances the gel formation.

Temperature‐Responsive Injectable Hydrogels Containing Gelatin and Cell Adhesion Peptides for Adipose‐Derived Stem Cell Delivery

ABSTRACTResearch on injectable polymers (IPs) has been actively conducted in recent decades for biomedical applications. Temperature‐responsive IPs are especially effective because they can be gelled by injecting them into a living organism without external contamination. Adipose‐derived stem cells (AdSCs) can be easily harvested in a minimally invasive manner and differentiated into various cell lineages. Versatile therapeutic applications have been developed through the secretion of various cytokines from AdSCs. In this study, we prepared IP hydrogels comprising a temperature‐responsive polymer with reactive succinimide groups (tri‐PCG‐OSu), a biomacromolecule (gelatin) as a crosslinker, and Pluronic with RGDS peptide (PL‐RGDS) as a cell adhesion factor to extend the duration of the gel state and improve cell engraftment in the IP hydrogels for AdSC delivery. The combined use of gelatin and cell adhesion peptides in the polymer matrix improved the fraction of living cells encapsulated in the IP hydrogels and increased the expression levels of angiogenic factors in AdSCs cultured within them. We also presume that a certain number of cells in the IP hydrogels could be differentiated into adipocytes using the differentiation‐inducing medium. These results suggest that our temperature‐responsive IP system could be used as a cell delivery material for regenerative medicine.

The role of presence of wormlike micelles of ionic surfactants on the sterilization efficiency of sodium hypochlorite

Abstract This paper describes an attempt to increase the sterilising efficacy of sodium hypochlorite (SH) by prolonging its shelf life in gel mode through the presence of wormlike micelles. No effect was observed on the presence of SH on the ratio of highest viscosity peak of 20:80 of 3 % (w/w) sodium dodecylsulfate (SDS) and cetyltrimethylammonium bromide (CTAB). On the other side, the presence of SH has a relatively negative effect on transformation process from spherical (three-dimensional, 3D) micelles to wormlike (one-dimensional, 1D) micelles. The gel state of the aqueous SH solution is maintained even at a ratio of 20:80 SDS:CTAB 3 % (w/w). Measurements of the biological activity of the gel using Staphylococcus aureus bacteria show that the sterilizing efficiency of SH is enhanced by the presence of 1D micelles. In contrast, the stability of SH using the kinetic method shows a sudden decrease in its stability due to the presence of 1D micelles, and the same is the case when both SDS and CTAB micelles are present. It was concluded that the increase in the biological activity of SH due to presence of micelles in gel or liquid mode resulted from their chemical interference, which acts as an antibacterial formulation.

Dynamically Cross-linked Oligo[2]rotaxane Networks Mediated by Metal-Coordination.

Polyrotaxanes (PRs) have attracted significant research attention due to their unique topological structures and high degrees of conformational freedom. Herein, we take advantage of an oligo[2]rotaxane to construct a novel class of dynamically cross-linked rotaxane network (DCRN) mediated by metal-coordination. The oligo[2]rotaxane skeleton offers several distinct advantages: In addition to retaining the merits of traditional polymer backbones, the ordered intramolecular motion of the [2]rotaxane motifs introduced dangling chains into the network, thereby enhancing the stretchability of the DCRN. Additionally, the dissociation of host-guest recognition and subsequent sliding motion, along with the breakage of metal-coordination interactions, represented an integrated energy dissipation pathway to enhance mechanical properties. Moreover, the resulting DCRN demonstrated responsiveness to multiple stimuli and displayed exceptional self-healing capabilities in a gel state. Upon exposure to PPh3, which induced network deconstruction by breaking the coordinated cross-linking points, the oligo[2]rotaxane could be recovered, showcasing good recyclability. These findings demonstrate the untapped potential of the oligo[2]rotaxane as a polymer skeleton to develop DCRN and open the door to extend their advanced applications in intelligent mechanically interlocked materials.

Calcium-Based Mineralized Hydrogels for Temporary Reinforcement and Conservation of Ancient Ivory Relics.

Ancient ivory serves as an important witness of time and historical events, offering highly significant insights into the fields of paleontology, mineralogy, materials science, and geochemistry. However, ancient ivory has undergone groundwater corrosion and has a loose porous structure and reduced mechanical strength due to being buried for a long time. Therefore, the temporary reinforcement and preservation of ancient ivory artifacts are a well-known challenge. A methodology was presented in this article for the synthesis of calcium-based mineralized hydrogels (Ca-gel), which possess controllable adhesive strength, beneficial compatibility, environmentally friendly and noninvasive protection, as well as efficient and rapid adhesion for ancient ivory cultural relics. By manipulating the various components of Ca-gel, it was possible to achieve a controllable gel time and gel state. Additionally, the hydrogel possessing a substantial water content has the potential to establish a humid environment suitable for the preservation of ancient ivory, thereby overcoming the challenges associated with water loss and weathering that may arise during excavation processes. It is noteworthy that Ca-gel possessed universality and temporary adhesive properties that could be employed in the temporary reinforcement of cultural relics from different materials. A method has been proposed in this study to facilitate the temporary reinforcement process while ensuring the protection of authenticity, integrity, and continuity for cultural relics.

Mechanistic study on the decline of foaming characteristics of egg white under heat stress: Emphasizing apparent phenomena, structure, and intermolecular interactions

Heat stress is a critical step in the processing of liquid egg white; however, this treatment can severely affect its foaming properties. This study aims to elucidate the mechanisms underlying the decline in foaming properties of liquid egg white during heat stress. The research begins by examining the adverse effects of heat stress on the foaming properties of liquid egg whites, where an increase in apparent viscosity, turbidity, and particle size is initially observed, indicating the formation of aggregates. After heat stress, the binding water capacity of the liquid egg white increases, intermolecular forces strengthen, and the secondary structure transforms towards β-sheet and β-turn configurations, while surface hydrophobicity decreases. Heat stress promotes the transition of liquid egg white into a more stable gel state. Additionally, electrophoresis results show the disappearance of bands for ovomucin subunit, ovotransferrin, and lysozyme, while microscopic observations reveal a rougher surface texture of the samples. In summary, this study provides insights and theoretical basis for understanding the mechanisms behind the decline in foaming properties of liquid egg whites under heat stress.

Detailed structural analyses and viscoelastic properties of nano-fibrillated bacterial celluloses

Nano-fibrillated bacterial cellulose (NFBC) can be prepared by cultivating a cellulose-producing bacterium in a medium containing a dispersant under agitating and aerobic conditions. Although NFBCs have various applications, their detailed structure and physical properties have not been clarified. Therefore, in this study, we performed detailed structural and physical property analyses of NFBCs to advance their potential applications. Atomic force microscopy and image analysis showed that the average fiber length of NFBCs was approximately 17 µm and fiber widths were 10–15 nm; the aspect ratios of NFBCs were > 1000, which are >10-fold higher than that of 2,2,6,6-tetramethylpioeridine-1-oxyl-oxidized cellulose nanofiber. Shear viscosity measurements showed that the NFBCs exhibited shear-thinning flow behavior even at low concentrations (0.01 wt%). Frequency sweep measurements showed that the storage modulus values were greater than the loss modulus values in the measured frequency range, indicating that the NFBCs were in a stable gel state. Thus, the NFBCs exhibited significantly longer fiber lengths, larger aspect ratios, and excellent viscoelastic properties based on these unique structural features. Our findings will help develop novel applications utilizing the ultrahigh aspect ratio unique to NFBC and its viscoelastic properties.

Spreadable thermosensitive nanocomposite hydrogel dressing with ultrasound-responsive bactericidal/repair-promoting regulation and cascade antioxidantion for infected burn wound repair

Treating severe burn wounds poses significant challenges, including considerable cell loss, excessive inflammation, and a high susceptibility to bacterial infections. Ideal burn dressings should exhibit excellent antibacterial properties, anti-inflammatory effects, and promote cell proliferation. Additionally, they need facilitate painless dressing changes and be user-friendly. Herein, we synthesized a thermosensitive hydrogel by crosslinking poly (N-isopropylacrylamide-co-allyloxybenzaldehyde) (PNA) and amino-terminated Pluronic F127 (APF) through a Schiff base reaction. It exhibited reversible gel-sol transition and spreadability. By incorporating piezoelectric gold nanoparticle-modified barium titanate (Au@BaTiO3) and cascade antioxidant MOF-818, a nanocomposite hydrogel dressing with diverse bioactive functionalities was developed. Results demonstrated that the nanocomposite hydrogel possessed gel-sol transition properties, maintained a stable gel state within a broad temperature range, and desirable self-healing property. Au@BaTiO3 exhibited good piezoelectric properties and ROS generation upon ultrasound stimulation, while MOF-818 displayed highly efficient cascade nanozyme activity. The combination of Au@BaTiO3 and MOF-818 promoted fibroblast proliferation and migration, reduced intracellular ROS levels, and induced anti-inflammatory polarization of macrophages under ultrasound stimulation. In vitro and in vivo antibacterial results disclosed that the nanocomposite hydrogel had excellent antibacterial activity under high-intensity ultrasound stimulation. When applied to infected burn wounds, the nanocomposite hydrogel can rapidly sterilize the wound upon initial high-intensity ultrasound, and then reduce inflammation and promote M2 macrophage polarization by the following low-intensity ultrasound stimulation, and thus accelerating the healing by improving granulation tissue formation, angiogenesis, and collagen deposition.

Chitosan-based bilayer shell phase change nano-capsules with excellent anti-permeability for thermal regulation dressings

Nano-encapsulated phase change materials (NEPCMs) with appropriate phase change temperature range and excellent anti-permeability have significant application value in the field of thermal regulation dressings. In this study, NEPCMs were synthesized using the microemulsion polymerization method, with eutectic fatty acids (LA-SA) as the core material and poly(methyl methacrylate) (PMMA) as the shell material. Subsequently, using the electrostatic adsorption method, chitosan (CS) was successfully coated onto the outer surface of NEPCMs, resulting in the preparation of a novel bilayer shell nano-encapsulated phase change materials (BS-NEPCMs) for thermal regulation dressings. The impact of core/shell ratio, CS acid solution concentration and cross-linking agent content on capsule properties was investigated. It was found that BS-NEPCMs exhibited excellent cyclical stability and thermal stability. In particular, the CS shell layer provided excellent interfacial impermeability effects for the capsules, achieving an anti-permeability efficiency of 96.21 %. This not only helps address the problem of high leakage rates in single wall capsules, but also ensures that the capsules maintain high phase change enthalpies of 99.32 J/g and 96.38 J/g, respectively. The dressings based on BS-NEPCMs demonstrated good thermal regulation at 33–42 °C with maximum phase change enthalpies of 39.53 J/g and 34.08 J/g, respectively. Swelling and rheological analysis showed that the dressing exhibits a gel state, with a swelling ratio of 343 %, an elastic modulus of 15 kPa and a viscous modulus of 4 kPa. This study indicated that BS-NEPCMs hold significant promise for various applications in energy storage and body thermal regulation fields.

Chitosan-Alginate Gels for Sorption of Hazardous Materials: The Effect of Chemical Composition and Physical State.

Chitosan, alginate, and chitosan-alginate (50:50) mixed hydrogels were prepared by freeze casting, freeze-drying, and subsequent physical cross-linking. Chitosan was cross-linked with citrate and alginate with calcium ions, while the mixed gels were cross-linked with both cross-linking agents. Both cryogels and xerogels were obtained by lyophilization and drying of the hydrogels. We investigated the effect of the chemical composition and the physical state of gels on the gel structure and sorption of model dyes. Alginate and mixed gels cross-linked with Ca2+ ions sorbed 80-95% of cationic dye from the solutions. The chitosan gels are primarily capable of adsorbing anionic dyes, but at near-neutral pH, their capacity is lower than that of alginate gels, showing 50-60% dye sorption. In the case of alginate gels, the dye sorption capacity of xerogels, cryogels, and hydrogels was the same, but for chitosan gels, the hydrogels adsorbed slightly less dye than the dried gels.

Multiple stimuli-responsive low-molecular-weight organogel with room temperature phosphorescence for dynamic anti-counterfeiting

Pure organic luminogens with stimuli-responsive room temperature phosphorescence (RTP) have drawn much attention due to their promising applications in dynamic anti-counterfeiting. In this work, we designed a simple organic molecule with rigid chemical structure (m-FBCM), and all-atom molecular dynamics simulation indicated that it was a potential organogelator. Moreover, the molecule comprises multiple carbonyl units and aromatic rings, which could promote the intersystem crossing process. Our experiments revealed that m-FBCM could form stable gel in DMSO, promoted by balanced intermolecular π-π interactions. Green afterglow was observed at room temperature in the gel state with lifetime 41.6 ms, ascribed to its RTP. The afterglow became invisible at 45 °C and could recover upon cooling to room temperature. Moreover, the N-acylation reaction between m-FBCM xerogel and vapor of volatile primary amine could occur in a few minutes without additional catalyst, providing an orange afterglow. The thermal-responsive and chemical-reponsive properties impart the RTP gel promising application in dynamic anti-counterfeiting.

Formation of Self-Healing Granular Eutectogels through Jammed Carbopol Microgels in Supercooled Deep Eutectic Solvent.

Typically, gel-like materials consist of a polymer network structure in a solvent. In this work, a gel-like material is developed in a deep eutectic solvent (DES) without the presence of a polymer network, achieved simply by adding microgels. The DES is composed of choline chloride and citric acid and remains stably in a supercooled state at room temperature, exhibiting Newtonian fluid behavior with high viscosity. When the microgel (Carbopol) concentration exceeds 2 wt %, the DES undergoes a transition from a liquid to a soft gel state, characterized as a granular eutectogel. The soft gel characteristics of eutectogels exhibit a yield stress, and their storage moduli exceed the loss moduli. The yield stress and storage moduli are observed to increase with increasing microgel concentration. In contrast, the ion conductivity decreases with increasing microgel concentration but eventually levels off. Because the eutectogel can dissolve completely in excess water, it is a physical gel-like material, attributed to the densely packed structure of microgels in the supercooled DES. Due to the absence of networks, the granular eutectogel has the capability to self-heal simply by being pushed together after being cut into two pieces.

Molecularly Engineered Supramolecular Thermoresponsive Hydrogels with Tunable Mechanical and Dynamic Properties.

Synthetic supramolecular polymers and hydrogels in water are emerging as promising biomaterials due to their modularity and intrinsic dynamics. Here, we introduce temperature sensitivity into the nonfunctionalized benzene-1,3,5-tricarboxamide (BTA-EG4) supramolecular system by incorporating a poly(N-isopropylacrylamide)-functionalized (BTA-PNIPAM) moiety, enabling 3D cell encapsulation applications. The viscous and structural properties in the solution state as well as the mechanical and dynamic features in the gel state of BTA-PNIPAM/BTA-EG4 mixtures were investigated and modulated. In the dilute state (c ∼μM), BTA-PNIPAM acted as a chain capper below the cloud point temperature (Tcp = 24 °C) but served as a cross-linker above Tcp. At higher concentrations (c ∼mM), weak or stiff hydrogels were obtained, depending on the BTA-PNIPAM/BTA-EG4 ratio. The mixture with the highest BTA-PNIPAM ratio was ∼100 times stiffer and ∼10 times less dynamic than BTA-EG4 hydrogel. Facile cell encapsulation in 3D was realized by leveraging the temperature-sensitive sol-gel transition, opening opportunities for utilizing this hydrogel as an extracellular matrix mimic.

Chemiluminescent Reaction Induced by Mixing of Fluorescent-Dye-Containing Molecular Organogels with Aqueous Oxidant Solutions.

Chemiluminescence in solution-based systems has been extensively studied for the chemical analysis of biomolecules. However, investigations into the control of chemiluminescence reactions in gel-based systems, which offer flexibility in reaction conditions (such as the softness of the reaction environment), have only recently begun in polymer materials, with limited exploration in low-molecular-weight gelator (LMWG) systems. In this study, we investigated the chemiluminescence behaviors in the gel states using LMWG systems and evaluated their applicability to fluorescent-dye-containing molecular organogel systems/oxidant-containing aqueous systems. Using diethyl succinate organogels composed of 12-hydroxystearic acid as a molecular organogelator, we examined the fluorescent properties of various fluorescent dyes mixed with oxidant aqueous solutions. As the reaction medium transitioned from the solution to the gel state, the emission color and chemiluminescence duration changed significantly, and distinct characteristics were observed, for each dye. This result indicates that the chemiluminescence behavior differs significantly between the solution and gel states. Additionally, visual inspection and dynamic viscoelastic measurements of the mixed fluorescent dye-containing molecular gels and oxidant-containing aqueous solutions confirmed that the chemiluminescence induced by the mixing occurred within the gel phase. Furthermore, the transition from the solution to the gel state may allow for the modulation of the mixing degree, thereby enabling control over the progression of the chemiluminescence reaction.