Based on the wind tunnel test data of a long-span spatial roof structure, the correlation between higher-order statistics and peak factors was obtained according to the time and frequency domain characteristics of wind pressure-time history, as well as the coincidence condition between wind pressure power spectra of measurement points and wind speed power spectra. A simplified peak factor calculation formula was proposed based on the moment-based Hermite polynomial model. The Gaussian part of the peak factor was calculated through the wind speed spectrum based on the zero-crossing theory, and the parameters related to higher-order statistics were considered as the non-Gaussian part of the peak factor. The simplified method was verified through the instantaneous extreme value method based on a coal shed structure with available long-term wind pressure-time history. It revealed that the results of the proposed simplified method correlate well with that of the instantaneous extreme value method, indicating its accuracy and potential value for engineering practice.