This study aims at modeling and investigating the impact of realistic turbulence inhomogeneity on radiowave propagation by utilizing large eddy simulations (LES). An up-to-date version of the X-LES method for generating realistic turbulent phase screens is first introduced. It combines atmospheric simulations with the classical Tatarski statistical modeling. This method naturally incorporates vertical turbulence inhomogeneity into phase screens at scales resolved by LES. It is then extended to sub-grid scales by weighting statistically generated phase variations with the vertical profile of the turbulent structure constant extracted from atmospheric data. This method is applied to replicate turbulence of a classical tropical marine atmospheric boundary layer. The impact of the generated medium on the propagation of a 10 GHz spherical wave emanating from a Gaussian aperture is analyzed through a statistical study of log-amplitude profiles performed for three different source altitudes. Results first show that contrary to a classical homogeneous turbulence modeling, log-amplitude profiles resulting from the propagation into inhomogeneous turbulence exhibit a statistical heterogeneity strongly dependent of source altitude. Furthermore, classical stochastic phase screen generation from a homogeneous Von-Kàrmàn Kolmogorov spectrum seems to give a statistically significant underestimation of the actual impact of turbulence compared to the X-LES method.