Background: Most endodontic failures result from incomplete root canal sealing. For successful treatment, obturation materials must have excellent sealing properties, and the techniques used should minimally impact their sealing effectiveness.Objective: To compare the apical seal integrity utilizing the AH-PLUS sealer in immediate versus delayed post-space preparation.Materials and Methods: This study was conducted at the Operative Dentistry Department of Liaquat University of Medical and Health Sciences, Jamshoro. Fourteen teeth were randomly split into two groups of seven. Lateral compaction used AH Plus sealer (Dentsply) and gutta-percha. In group 1, Gates Glidden drills at 9000 rpm and a heated instrument created a post gap immediately after obturation, leaving 4 mm of gutta-percha apically. Group 2 teeth were immersed in saline at 37°C for one week before creating the post space using the same technique. The AH Plus sealer was used to test apical seal integrity in both groups.Results: In group 1 (Immediate post-space preparation) and group 2 (Delayed post-space preparation), 2 (28.6%) and 0 (0.0%) of 14 teeth had no apical seal integrity loss, while 5 (71.4%) and 7 (100.0%) had it. Compared to group 2 (Delayed post-space preparation), group 1 (Immediate post-space preparation) had considerably lower mean apical leakage (P-Value = 0.049) at 0.28 ± 0.38 mm.Conclusion: Apical seal integrity achieved by utilizing the AH-PLUS sealer is more favorable in immediate post-space preparation as compared to delayed post-space preparation after obturating the root canal system.Keywords: Apical, Integrity, Leakage, Preparation, Sealer.
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