Gatekeeper Function Research Articles

A GLOBAL COMPARISON OF CREDIT BUREAUS BASED ON DATA UTILIZATION IN CREDIT SCORING

The basic concept of credit scoring is to assess an individual`s payment ability as well as the specific individual`s credit default risk, hence determining an individual`s creditworthiness. Based on the credit score, financial institutions, insurance companies, telecommunication companies and other businesses decide whether consumers are eligible for a mortgage, credit card, auto loan, and other credit products. However, in many countries, potential tenants and insurance applicants also use credit scores extensively for screening. Accordingly, Credit Bureaus (CB) or Consumer Reporting Agencies (CRA) exert an essential gatekeeper function for important economic areas of consumers’ everyday life. However, when examining CBs globally, there are considerable differences in the use of data to calculate credit scores. Interestingly, the influence of CBs on credit rating receives little to no attention in academic research. This is particularly evident in the absence of a framework for classifying Credit Bureaus. Therefore, 24 traditional and non-traditional Credit Bureaus operating in 17 different countries are analyzed. First, the study identifies the different data types underlying credit reports and credit scores. Second, CBs are classified and clustered according to the type of information used for credit scoring. Furthermore, promising areas of research, in particular the ethical conflict between data protection and economic participation are highlighted.

Strategi Media JPNN.Com dalam Upaya Menyeimbangkan Churnalism dan Jurnalisme dalam Pemberitaan

The digital era has an impact on changing new work patterns in journalism, "Churnalism" is a new journalism that occurs as a consequence of the development of digital technology in the modern era. Churnalism is the simplicity of the way to obtain journalistic news content caused by technological advances. Churnalism threatens the quality of news in the digital era. JPNN.com is a news media that was established in 2008, experiencing a transition from the print media era to digital media. This research focuses on finding out and understanding JPNN.com media strategies in balancing Churnalism and journalism. This research is a qualitative research with a descriptive analysis approach, aiming to understand the process of Churnalism practice JPNN.com and understand their strategies in an effort to balance Churnalism and journalism. The results of this study show that JPNN.com has its own strategy in balancing Churnalism and journalism, namely a combination strategy, combining the practice of Churnalism with conventional journalism practices. The implementation of the combination strategy is carried out in six stages, including: First, journalists select potential news materials from online sources. Second, journalists research news materials to ensure the validity of the news. Third, journalists confirm with the source. Fourth, journalists combine Churnalism and conventional journalism in the reporting process. Fifth, the editor maintains the Gatekeeper function through news selection. Sixth, the editorial management conducts news every day.

‘And Along Came DNA’: The Introduction of DNA Evidence in Australian Courts in the Applebee case

ABSTRACT In 1989, serial offender Desmond Applebee was tried in the Australian Capital Territory for the rape of a young woman. A first for Australian courts, the prosecution tendered DNA evidence to counter Applebee’s alibi that he had been unconscious in his car at the time. However, despite the handling of novel scientific evidence being hotly debated at the time, the trial failed to engage with the legal issues this new evidence raised. The defence was unprepared and under-resourced to put into issue evidentiary principles; there was no systemic means for addressing the issues raised by novel scientific evidence if the defence did not do so. This paper argues that the Applebee case is a dissatisfying case of first impression, graphically illustrating the struggles legal systems can have interrogating novel scientific evidence. The case helped smooth adoption of this new form of evidence. How courts receive and respond to scientific evidence is today again in mind owing to the recent quashing of Kathleen Folbigg’s murder conviction following genetic discoveries; Applebee shows why relying on a particular defendant and particular defence counsel to carry out a gate-keeping function for admissibility of novel evidence collides with practical realities of the court system.

An ‘E’ for ‘elite’ in EMI? Global, local and elite dimensions in the promotion of English-medium university programmes

ABSTRACT The move towards EMI in higher education has been connected to university internationalisation, which reflects neoliberal trends. Research has underscored the need to consider socio-economic factors, materialities and ideologies surrounding EMI. Our study taps into this line of inquiry by focusing on how Swedish universities promote EMI programmes in business and economics in four videos. We take a novel approach to examine discursively constructed ideologies surrounding EMI by conducting a critical multimodal analysis of the videos. The analysis reveals how the use and representations of English – combined with different symbols, artefacts and concepts – are used to position these EMI programmes as both global and local. References to international rankings and multinational business partnerships position them on the global education market. At the same time, the programmes are locally situated in the academic tradition and entrepreneurial context of Sweden. Images of nature, the fika, or Scandinavian design present them in a way similar to tourist destinations. Tokens of economic and cultural eliteness create an extra layer of distinction, contributing to the added ‘elite’ value of EMI, where English is both taken for granted and serves a gate-keeping function. Findings provide insight into how EMI is promoted to international students.

Endothelial RUNX3 controls LSEC dysfunction and angiocrine LRG1 signaling to prevent liver fibrosis.

Liver fibrosis represents a global health burden, given the paucity of approved antifibrotic therapies. Liver sinusoidal endothelial cells (LSECs) play a major gatekeeping role in hepatic homeostasis and liver disease pathophysiology. In early tumorigenesis, runt-related transcription factor 3 (RUNX3) functions as a sentinel; however, its function in liver fibrosis in LSECs remains unclear. This study aimed to investigate the role of RUNX3 as an important regulator of the gatekeeping functions of LSECs and explore novel angiocrine regulators of liver fibrosis. Mice with endothelial Runx3 deficiency develop gradual and spontaneous liver fibrosis secondary to LSEC dysfunction, thereby more prone to liver injury. Mechanistic studies in human immortalized LSECs and mouse primary LSECs revealed that IL-6/JAK/STAT-3 pathway activation was associated with LSEC dysfunction in the absence of RUNX3. Single-cell RNA sequencing and quantitative RT-PCR revealed that leucine-rich alpha-2-glycoprotein 1 (LRG1) was highly expressed in RUNX3-deficient and dysfunctional LSECs. In in vitro and coculture experiments, RUNX3-depleted LSECs secreted LRG1, which activated hepatic stellate cells via TGFBR1-SMAD2/3 signaling in a paracrine manner. Furthermore, circulating LRG1 levels were elevated in mouse models of liver fibrosis and in patients with fatty liver and cirrhosis. RUNX3 deficiency in the endothelium induces LSEC dysfunction, LRG1 secretion, and liver fibrosis progression. Therefore, endothelial RUNX3 is a crucial gatekeeping factor in LSECs, and profibrotic angiocrine LRG1 may be a novel target for combating liver fibrosis.

Public Transport in Pre-Apartheid Literary Johannesburg: Between Progress and Oppression

ABSTRACT A close reading of literary representations of Johannesburg’s public transport in the early decades of the 20th century gives insight into the intricate way in which freedom, mobility, and narratives of progressive modernity interlink with urban mobility regimes of public transportation. The literary representations mark public transport simultaneously as progressive and oppressive, depending on access. Where access is denied, public vehicles become part of an oppressive racist mobility regime and exclude individuals from formative experiences of collective belonging. The present analysis engages with selected concepts from the field of mobility studies, namely Cresswell’s thoughts on the relationship of mobility and modern citizenship, Bissell’s observations regarding ‘mobile collectives’, and the idea of ‘throwntogetherness’ by the social geographer Massey. These will be used to analyze the gatekeeping function of public transport in representations of early Johannesburg, where black, male, urban subjecthood is negotiated against white urban modernity.

The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis

In mammals, the circadian clock network drives daily rhythms of tissue-specific homeostasis. To dissect daily inter-tissue communication, we constructed a mouse minimal clock network comprising only two nodes: the peripheral epidermal clock and the central brain clock. By transcriptomic and functional characterization of this isolated connection, we identified a gatekeeping function of the peripheral tissue clock with respect to systemic inputs. The epidermal clock concurrently integrates and subverts brain signals to ensure timely execution of epidermal daily physiology. Timely cell-cycle termination in the epidermal stem cell compartment depends upon incorporation of clock-driven signals originating from the brain. In contrast, the epidermal clock corrects or outcompetes potentially disruptive feeding-related signals to ensure the optimal timing of DNA replication. Together, we present an approach for cataloging the systemic dependencies of daily temporal organization in a tissue and identify an essential gate-keeping function of peripheral circadian clocks that guarantees tissue homeostasis.

Differences in emergency department visits and hospitalization between German and Dutch nursing home residents: a cross-national survey

Key summary pointsAimWhat is the difference in the frequency of transfers to hospital between German and Dutch nursing home residents?FindingsIn German nursing homes, residents are transported to hospital more often than in the Netherlands (e.g., at least one emergency department visit during last year: 26.5% vs. 7.9%, p < 0.0001). General practitioners in Germany are less involved in the transfer decision than elder care physicians in the Netherlands.MessageThe differences are probably mainly due to differences in the health and care systems (e.g., very strong gatekeeper function of the general practitioner/elder care physician in the Netherlands).

"So at least now I know how to deal with things myself, what I can do if it gets really bad again"-experiences with a long-term cross-sectoral advocacy care and case management for severe multiple sclerosis: a qualitative study.

Persons with severe Multiple Sclerosis (PwsMS) face complex needs and daily limitations that make it challenging to receive optimal care. The implementation and coordination of health care, social services, and support in financial affairs can be particularly time consuming and burdensome for both PwsMS and caregivers. Care and case management (CCM) helps ensure optimal individual care as well as care at a higher-level. The goal of the current qualitative study was to determine the experiences of PwsMS, caregivers and health care specialists (HCSs) with the CCM. In the current qualitative sub study, as part of a larger trial, in-depth semi-structured interviews with PwsMS, caregivers and HCSs who had been in contact with the CCM were conducted between 02/2022 and 01/2023. Data was transcribed, pseudonymized, tested for saturation and analyzed using structuring content analysis according to Kuckartz. Sociodemographic and interview characteristics were analyzed descriptively. Thirteen PwsMS, 12 caregivers and 10 HCSs completed interviews. Main categories of CCM functions were derived deductively: (1) gatekeeper function, (2) broker function, (3) advocacy function, (4) outlook on CCM in standard care. Subcategories were then derived inductively from the interview material. 852 segments were coded. Participants appreciated the CCM as a continuous and objective contact person, a person of trust (92 codes), a competent source of information and advice (on MS) (68 codes) and comprehensive cross-insurance support (128 codes), relieving and supporting PwsMS, their caregivers and HCSs (67 codes). Through the cross-sectoral continuous support in health-related, social, financial and everyday bureaucratic matters, the CCM provides comprehensive and overriding support and relief for PwsMS, caregivers and HCSs. This intervention bears the potential to be fine-tuned and applied to similar complex patient groups. The study was approved by the Ethics Committee of the University of Cologne (#20-1436), registered at the German Register for Clinical Studies (DRKS00022771) and in accordance with the Declaration of Helsinki.

Enduring elites in quoted sources: Institutional alignment in Finnish media, 1999–2018

Abstract This article addresses the question of whether and how sourcing practices of journalistic news media have been transformed by online-first publishing and the hybridisation of the media system. Focusing on four Finnish news outlets from 1999 to 2018 (a daily newspaper, a news agency, a tabloid, and a public broadcaster), we analyse the essential gatekeeping practice of giving voice to actors by quoting them directly or indirectly. According to our data, the hybrid media context does not lead to an increased diversification of sources. Instead, our analysis indicates a concentration and consolidation of sources across different news outlets: a continued elite source dominance in domestic political news. This development we term institutional alignment, suggesting that, by foregrounding elite sources, the news media seeks to maintain both its gatekeeping function and its key position in networks of power.

Aspirin overuse in primary prevention: nationwide temporal trends in low-dose aspirin therapy for primary prevention of cardiovascular disease in adults with and without diabetes

Abstract Background Aspirin therapy for primary prevention of cardiovascular disease (CVD) is controversial. European Society of Cardiology guideline recommendations have changed in the last decades, and aspirin is currently not recommended in individuals with low/moderate cardiovascular (CV) risk but may be considered in high-risk individuals with diabetes. Purpose We report temporal trends in primary prevention aspirin prescription among individuals with and without diabetes and describe characteristics of incident aspirin users. Methods Using Danish nationwide registries, we identified incident and prevalent aspirin users in a population ≥40 years without CVD, eligible for primary preventive aspirin therapy from 2000 through 2020. Temporal trends in aspirin use with and without diabetes were assessed, as were CV risk factors among incident users. Individuals in Denmark are primarily seen by general practitioners who have a gate-keeper function for secondary hospital-based care. Results A total of 522,680 individuals started aspirin therapy during the study period. The number of incident users peaked in 2002 (39,803 individuals, 1.78% of the eligible population) and was lowest in 2019 (11,898 individuals, 0.49%), with similar trends for subjects with and without diabetes (Figure 1). A large proportion of incident users had no CV risk factors (diabetes, hypertension, hypercholesterolemia, or chronic obstructive pulmonary disease [a proxy for smoking]); however, this proportion decreased from 53.9% in 2000 to 30.9% in 2020 (Figure 2). The number of prevalent aspirin users peaked at 7.7% in 2008 and was 3.3% in 2020. For subjects with diabetes, the peak was observed in 2009 at 38.5% and decreased to 17.1% in 2020. Conclusion Prescription of aspirin for primary prevention of CVD has decreased over the last two decades in individuals both with and without diabetes. However, aspirin appears to be inappropriately prescribed in many primary prevention adults as a large proportion of incident users had no CV risk factors. Efforts to inform appropriate prescription of aspirin are needed, e.g., by improved guidance for general practitioners.Figure 1Figure 2

The Window of Opportunity

Abstract This article explores UK bookselling in terms of the retail buying functions, promotional activity, merchandising, and stock management processes commonly adopted. The business structures and mechanisms that dictate organizational book buying in the UK market are also explored in terms of the time allowed for titles to succeed or fail. These very practical and logistical aspects of retailing are brought to life by the qualitative data obtained through seven semi-structured interviews in 2018–2019. The sample represented actors across the UK publishing industry supply chain but focused predominantly on the book buyer function. This research finds that the sale-or-return purchasing model, prevalent in the UK book trade, plays a crucial role in dictating the window of opportunity for books to succeed or fail; the book-buyer gatekeeper function is pivotal and highly sensitive to local demand; and that local demand is fulfilled through the curation of predictable or proven products in combination with novel or speculative products – the level of purchasing risk is dependent on retail location and footfall. These findings are aligned with organizational buyer behaviour, retail location theory, and buyer behaviour theory.

Guardians of the gut: influence of the enteric nervous system on the intestinal epithelial barrier.

The intestinal mucosal surface forms one of the largest areas of the body, which is in direct contact with the environment. Co-ordinated sensory functions of immune, epithelial, and neuronal cells ensure the timely detection of noxious queues and potential pathogens and elicit proportional responses to mitigate the threats and maintain homeostasis. Such tuning and maintenance of the epithelial barrier is constantly ongoing during homeostasis and its derangement can become a gateway for systemic consequences. Although efforts in understanding the gatekeeping functions of immune cells have led the way, increasing number of studies point to a crucial role of the enteric nervous system in fine-tuning and maintaining this delicate homeostasis. The identification of immune regulatory functions of enteric neuropeptides and glial-derived factors is still in its infancy, but has already yielded several intriguing insights into their important contribution to the tight control of the mucosal barrier. In this review, we will first introduce the reader to the current understanding of the architecture of the enteric nervous system and the epithelial barrier. Next, we discuss the key discoveries and cellular pathways and mediators that have emerged as links between the enteric nervous, immune, and epithelial systems and how their coordinated actions defend against intestinal infectious and inflammatory diseases. Through this review, the readers will gain a sound understanding of the current neuro-immune-epithelial mechanisms ensuring intestinal barrier integrity and maintenance of intestinal homeostasis.

Reimagining the Role of General Practitioners as Gatekeepers in South African Healthcare- A Review Focusing on Medical Schemes

This review provides insights into the role of GPs as gatekeepers in the South African healthcare system and emphasizes the importance of reimagining and reevaluating their role within the context of evolving healthcare reforms and the changing dynamics of medical schemes. The findings contribute to the ongoing discussion on optimizing the gatekeeping function to ensure equitable access to healthcare services while promoting efficient resource allocation and high-quality care.

Reimagining the Role of General Practitioners as Gatekeepers in South African Healthcare- A Review Focusing on Medical Schemes

This review provides insights into the role of GPs as gatekeepers in the South African healthcare system and emphasizes the importance of reimagining and reevaluating their role within the context of evolving healthcare reforms and the changing dynamics of medical schemes. The findings contribute to the ongoing discussion on optimizing the gatekeeping function to ensure equitable access to healthcare services while promoting efficient resource allocation and high-quality care.

Fajar.co.id Political Reporting: A Study on Editorial Policy Related to the Makassar Mayoral Election

This research explore Fajar.co.id’s editorial policies and editorial management process in political reporting, particularly concerning the 2020 Makassar Mayoral Election. This research uses an inductive qualitative analysis. Inductive analysis is an approach that begins with field facts, analyzes them based on relevant theories and arguments, and ultimately yields a conclusion. The results show that Fajar.co.id’s editorial policy in reporting the 2020 Makassar Mayoral Election prioritizes newsworthiness by ensuring each published news piece is widely discussed, offers interesting perspectives, and uses language easily understood by a broad spectrum of society from various backgrounds. The applied editorial management demonstrates that content control occurs in the initial writing phase, with editors playing a crucial role in editing and gatekeeping functions. Although published news becomes public domain, the editorial team remains responsible for ensuring the accuracy and integrity of content by correcting writing errors without altering the news substance. Therefore, it is recommended that Fajar.co.id’s editors and reporters continue honing their abilities in identifying and processing issues with high news value and social relevance while maintaining a balance between commercially appealing news and the importance of information for public interest. Fajar.co.id must keep its motto ‘wisdom on the unbiased line’. Furthermore, the importance of ongoing training in language skills enhancement to communicate news effectively to a diverse reader while ensuring that every presented news piece adheres to ethical journalism principles is emphasized. Additionally, the already robust control and gatekeeping system should continue to be strengthened to ensure any factual or linguistic errors can be promptly corrected without altering the essence of the news, to uphold and enhance Fajar.co.id’s credibility as a responsible and reliable news media.

A thrombophilic allele of clotting Factor VII/VIIa promoting recurrent pulmonary emboli, clinical details, and a structural model of the altered protein: a case report

BackgroundThe clotting or hemostasis system is a meticulously regulated set of enzymatic reactions that occur in the blood and culminate in formation of a fibrin clot. The precisely calibrated signaling system that prevents or initiates clotting originates with the activated Factor Seven (FVIIa) complexed with tissue factor (TF) formed in the endothelium. Here we describe a rare inherited mutation in the FVII gene which is associated with pathological clotting.Case presentationThe 52-year-old patient, with European, Cherokee and African American origins, FS was identified as having low FVII (10%) prior to elective surgery for an umbilical hernia. He was given low doses of NovoSeven (therapeutic Factor VIIa) and had no unusual bleeding or clotting during the surgery. In fact, during his entire clinical course he had no unprovoked bleeding. Bleeding instances occurred with hemostatic stresses such as gastritis, kidney calculus, orthopedic surgery, or tooth extraction, and these were handled without factor replacement. On the other hand, FS sustained two unprovoked and life-threatening instances of pulmonary emboli, although he was not treated with NovoSeven at any time close to the events. Since 2020, he has been placed on a DOAC (Direct Oral Anticoagulant, producing Factor Xa inhibition) and has sustained no further clots.Possible mechanism of (unauthorized) FVII activationFS has a congenitally mutated FVII/FVIIa gene, which carries a R315W missense mutation in one allele and a mutated start codon (ATG to ACG) in the other allele, thus rendering the patient effectively homozygous for the missense FVII. Structure based comparisons with known crystal structures of TF-VIIa indicate that the patient's missense mutation is predicted to induce a conformational shift of the C170's loop due to crowding of the bulky tryptophan to a distorted "out" position (Fig. 1). This mobile loop likely forms new interactions with activation loop 3, stabilizing a more active conformation of the FVII and FVIIa protein. The mutant form of FVIIa may be better able to interact with TF, displaying a modified serine protease active site with enhanced activity for downstream substrates such as Factor X.ConclusionsFactor VII can be considered the gatekeeper of the coagulation system. Here we describe an inherited mutation in which the gatekeeper function is altered. Instead of the expected bleeding manifestations resulting from a clotting factor deficiency, the patient FS suffered clotting episodes. The efficacy of the DOAC in treating and preventing clots in this unusual situation is due to its target site of inhibition (anti-Xa), which lies downstream of the site of action of FVIIa/TF.

The codification of nineteenth-century etiquette

AbstractEtiquette has only marginally attracted the attention of politeness scholars. This article aims to fill a knowledge gap as it explores the concept in a more systematic way, using nineteenth-century prescriptive metasources from four countries (Britain, France, Italy and the United States). Etiquette is found to form a complicated, all-encompassing body of tendentially amoral, mandatory norms, adapting the minutiae of court protocol to private settings. Since the conventions of etiquette are sequentially structured as scripts with a social gatekeeping function, they can be seen as rituals – that is, schematic, performative interaction that is emotionally invested. Furthermore, given the combination of mandatory behaviour and a concern for rank (precedence), etiquette is seen as a manifestation of Discernment, although etiquette privileges non-verbal aspects of interaction, with less attention for language advice. I consider “etiquette” to be a historically and geographically situated first-order term for the analytical concept of Discernment: emerging in Europe and in North America in the late eighteenth century, it is still in use today.

Authorship and individualization in the digital public sphere

Authorship and individualization in the digital public sphere

Functional basis for calmodulation of the TRPV5 calcium channel.

Within the transient receptor potential (TRP) superfamily of ion channels, TRPV5 is a highly Ca2+ -selective channel important for active reabsorption of Ca2+ in the kidney. Its channel activity is controlled by a negative feedback mechanism involving calmodulin (CaM) binding. Combining advanced microscopy techniques and biochemical assays, this study characterized the dynamic lobe-specific CaM regulation. We demonstrate for the first time that functional (full-length) TRPV5 interacts with CaM in the absence of Ca2+ , and this interaction is intensified at increasing Ca2+ concentrations sensed by the CaM C-lobe that achieves channel pore blocking. Channel inactivation occurs without requiring CaM N-lobe calcification. Moreover, we show a Ca2+ -dependent binding stoichiometry at the single channel level. In conclusion, our study proposes a new model for CaM-dependent regulation - calmodulation - of this uniquely Ca2+ -selective TRP channel TRPV5 that involves apoCaM interaction and lobe-specific actions, which may be of significant physiological relevance given its role as gatekeeper of Ca2+ transport in the kidney. KEY POINTS: The renal Ca2+ channel TRPV5 is an important player in maintenance of the body's Ca2+ homeostasis. Activity of TRPV5 is controlled by a negative feedback loop that involves calmodulin (CaM), a protein with two Ca2+ -binding lobes. We investigated the dynamics of the interaction between TRPV5 and CaM with advanced fluorescence microscopy techniques. Our data support a new model for CaM-dependent regulation of TRPV5 channel activity with CaM lobe-specific actions and demonstrates Ca2+ -dependent binding stoichiometries. This study improves our understanding of the mechanism underlying fast channel inactivation, which is physiologically relevant given the gatekeeper function of TRPV5 in Ca2+ reabsorption in the kidney.