Gastrointestinal Motility In Health Research Articles

Contractility patterns and gastrointestinal movements monitored by a combined magnetic tracking and motility testing unit.

Ingestible wireless capsules, including the 3D-transit magnetic capsule and the wireless motility capsule (WMC), describe gastrointestinal (GI) motility from changes in position or pressure. This study aimed to combine information on contractile events in terms of position (assessed with the 3D-transit) and change in pressure (assessed with the WMC) throughout the entire GI tract. The 3D-transit capsule and WMC were combined into a single-wireless unit system. Three-dimensional space-time coordinates, pressure, and pH data from a pilot case were analyzed as the combined unit passed the GI tract. Two single and three continuous contraction patterns were defined according to pressure changes and quantified through the GI tract. The combined unit was well tolerated and provided information on contractions throughout the gut. Single contraction patterns with no significant progressive movement of the unit were most prevalent in the stomach and the rectosigmoid colon. During the continuous contraction patterns, the unit moved in an antegrade or retrograde direction. Longer distance and higher velocity were seen during antegrade than during retrograde movements. The motility indices (as measured with WMC) in combined ascending, transverse and descending colon showed a positive linear association (r=0.7) to the capsule movements (as measured with 3D-transit). The combined system provides synchronous information about movements and gut contractions. These measurements can be used to extract more information from existing recordings and may enhance our understanding of GI motility in health and disease.

Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission.

Recent studies implicate TRPV4 receptors in visceral pain signaling and intestinal inflammation. Our aim was to evaluate the role of TRPV4 in the control of gastrointestinal (GI) motility and to establish the underlying mechanisms. We used immunohistochemistry and PCR to study TRPV4 expression in the GI tract. The effect of TRPV4 activation on GI motility was characterized using in vitro and in vivo motility assays. Calcium and nitric oxide (NO) imaging were performed to study the intracellular signaling pathways. Finally, TRPV4 expression was examined in the colon of healthy human subjects. We demonstrated that TRPV4 can be found on myenteric neurons of the colon and is co-localized with NO synthase (NOS-1). In vitro, the TRPV4 agonist GSK1016790A reduced colonic contractility and increased inhibitory neurotransmission. In vivo, TRPV4 activation slowed GI motility and reduced stool production in mouse models mimicking pathophysiological conditions. We also showed that TRPV4 activation inhibited GI motility by reducing NO-dependent Ca(2+) release from enteric neurons. In conclusion, TRPV4 is involved in the regulation of GI motility in health and disease. • Recent studies implicate TRPV4 in pain signaling and intestinal inflammation. • Our aim was to characterize the role of TRPV4 in the control of GI motility. • We found that TRPV4 activation reduced colonic contractility. • Our studies also showed altered TRPV4 mRNA expression in IBS-C patients. • TRPV4 may be a novel pharmacological target in functional GI diseases.

Standards for diagnosis gastrointestinal motility disorders. Section: ultrasonography position statement from the Gruppo Italiano di Studio Motilità Apparato Digerente (GISMAD)

Ultrasonography is a non-invasive, relatively easy, validated and reproducible technique. We assessed the usefulness of functional ultrasonography to study disorders of gastro-oesophageal tract, gallbladder and pancreatic duct. Oesophagus Oesophagus and the gastro-oesophageal junction can be visualized in children up to 5 years old. Ultrasonography shows 100% sensitivity and 87.5% specificity compared to ambulatory pH-metry for gastro-oesophageal reflux disease diagnosis. Stomach Ultrasonography can be used to estimate whole gastric volume, antral area or diameters, antro pyloric volume, transpyloric flow in fasting state and in response to test meal. Gallbladder Ul-trasonography is reliable to estimate volume in fasting state and in response to test meal or exogenous stimulus. For both stomach and gallbladder, indications might include the study of healthy subjects and of pathophysiologically relevant conditions such as dysmotility-like dyspepsia, suspicion of delayed gastric emptying, diabetes mellitus, gallstone disease and effect of drugs either delaying or accelerating motility. Common bile duct Ultrasonography can be used to estimate interprandial and postprandial common bile duct diameter in patients with clinical suspicion of common bile duct obstruction in fasting state and in response to test meal or exogenous stimuli. Although functional ultrasonography is used mainly for research purposes, its simplicity makes it appealing for clinical use to assess gastrointestinal motility in health and disease.

Gastro-intestinal motility in health and critical disease

Gastro-intestinal motility in health and critical disease

Atlas of gastrointestinal motility in health and disease: Edited by Marvin M. Schuster. 320 Pp. $95.00. Williams And Wilkins, Baltimore, Maryland, 1993. Isbn 0-683-07623-X

Atlas of gastrointestinal motility in health and disease: Edited by Marvin M. Schuster. 320 Pp. $95.00. Williams And Wilkins, Baltimore, Maryland, 1993. Isbn 0-683-07623-X

Pattern recognition of canine duodenal contractile activity.

An application of statistical pattern recognition technique to the classification of canine duodenal contractile activity resulting from the ingestion of three different test meals, viz. water, acid, and solid, is described. Feature vectors were extracted from the contractile activities recorded by means of strain gauges, and were based on average duration, number, and intensities of contractions, as well as their frequency and propagational characteristics. Pattern training and classification were performed via the Bayes decision rule. The resuits indicate that the three different meals give rise to three different kinds of contractile activities. An improvement in the classifier's performance was observed when it was updated with correctly classified patterns. The results appear to suggest that pattern analysis techniques add a new dimension to the study of gastrointestinal motility in health and disease. For example, pattern recognition techniques can also be extended to identify contractile patterns altered due to such pathological conditions as irritable bowel syndrome and postoperative diarrhea and, hence, elucidate the underlying relationship between contractile activity and distal propulsion of contents.

Guts and Their Motions (Gastrointestinal Motility in Health and Disease)

In the last decade, a much greater understanding of human upper intestinal motility has been obtained. The existence of a cyclical fasting pattern is now recognized, associated with intermittent secretion and propulsion of material through the stomach and small intestine. This pattern changes after the ingestion of food, the duration of the disruption depending upon both quality and quantity of nutrient ingested. The present clinical relevance of this phenomenon is twofold. 1) In normal fasting persons, the passage and absorption by the small intestine of food and drugs may be influenced by such periodic changes. 2) Motility abnormalities in disease states may account for associated gastrointestinal symptoms. While the number of disorders showing clinically relevant motor dysfunction is small, continuing study will undoubtedly bring others to light, and may even provide a rational basis for therapy.

Gastrointestinal Motility in Health and Disease

Gastrointestinal Motility in Health and Disease

Book Review: Gastrointestinal Motility in Health and Disease

Book Review: Gastrointestinal Motility in Health and Disease

Gastrointestinal Motility in Health and Disease.

Gastrointestinal Motility in Health and Disease.

Gastrointestinal Motility in Health and Disease

Gastrointestinal Motility in Health and Disease

Gastrointestinal Motility in Health and Disease

Gastrointestinal Motility in Health and Disease