The focus in study of the central part of Nepsko-Botuobinskaya anteclise is concentrated on the subsalt oil and gas bearing horizons of group B (Osinsky, Upper Ust-Kutsky, Lower Ust-Kutsky, Preobrazhensky horizons) and V (terrigenous formations of Vendian age). However, higher, in the Lower-Middle Cambrian carbonate-halogen deposits, there are also promising horizons of group A (Kelorsky, Atovsky, Khristoforovsky, Balykhtinsky), oil and gas presence of a sufficient amount of the Angara-Lena stage, the northern part of the Nepsko-Botuobinskaya anteclise and adjacent structures. The paper examines the results of geochemical studies of oil samples from the Osinsky horizon (layer B1) and the nameless dolomite layer located between the salts in the lower part of the Upper Usolskaya subformation, previously considered gas-bearing at best. The conducted studies by the method of chromatography-mass spectrometry and comparison of the geochemical parameters of oils from different reservoirs show the similarity of hydrocarbon fluids of the Upper Usolskaya subformation and lower productive horizons, which makes it possible to attribute them to a single oil and gas bearing system.