The transition to a hydrogen economy is vital for achieving sustainable transport in Malaysia, particularly in mitigating the environmental impact of heavy-duty mobility. This paper proposes a preliminary methodological framework to evaluate hydrogen's potential as a transformative solution for decarbonizing the transportation sector, focusing on key areas such as hydrogen production, storage, distribution, and vehicle integration, with an emphasis on green hydrogen from renewable sources. Our assessment reveals the significant potential of hydrogen to reduce greenhouse gas emissions and air pollutants, positioning it as a viable alternative to fossil fuels and battery-electric vehicles, especially in heavy-duty applications. The study assesses the technological feasibility, economic viability, and environmental benefits of adopting hydrogen in Malaysia, considering current infrastructure, production capabilities, and regulatory frameworks. Key challenges identified include the high costs of hydrogen production and infrastructure, technological barriers in storage and vehicle integration, and gaps in policy and market readiness. To address these, we propose strategic recommendations for stakeholders, highlighting the need for government support, public-private partnerships, and international collaborations. This framework aims to guide Malaysia’s transition to a hydrogen-powered transport sector, aligning with the nation’s sustainability and energy security goals while positioning Malaysia as a leader in hydrogen technology in Southeast Asia.