Nano-satellites of cubesat format can be used effectively to study different aspects of space weather phenomena, such as high energy charge particle flux variations at near-Earth space as well as for monitoring cosmic gamma-ray bursts (GRBs) and hard X-ray and gamma-ray emission of solar flares. Using a constellation of CubeSats enables cost-effective synchronous measurements of radiation fluxes at different points in space, effectively separating the spatial and temporal effects of observed flux variations.Since July 5, 2019, M. V. Lomonosov Moscow State University (MSU) has realized its own program of cubesat employment. To the present date, 18 satellites in 1.5U, 3U, and 6U formats with the instruments developed at MSU have been launched, and 11 of them continue to operate on the solar-synchronous low-altitude orbits (400–600 km). The number of instruments elaborated especially for cubesats includes the universal Detector of Cosmic Radiation (DeCoR-1, DeCoR-2, and DeCoR-3 modifications), the Advanced Ultraviolet Radiometer (AURA, AURA-2) and the Complex Radiation Detector (CoRaD, i.e., KODIZ in Russian acronym). The DeCoR-1, DeCoR-2 and DeCoR-3 instruments allow for the detection of gamma-quanta and electrons in the energy ranges of 0.02–2.0 MeV and 0.3–10.0 MeV, respectively. The KODIZ instrument is intended especially to detect protons with energies higher than 300 MeV and electrons with energies higher than several MeV. The AURA and AURA-2 instruments are used to monitor atmospheric UV glow in ∼200–400 nm bands. Up until now, the good experience has been accumulated by using these instruments to measure different space weather effects, such as polar cups filling with solar cosmic rays, the dynamics of outer belt boundaries during geomagnetic storms, and electron precipitation in different areas of near-Earth space, including low-latitude regions. As a by-product, a number of GRB candidates were detected. The possibility of further development of multi-satellite group and perspectives to study the mentioned phenomena will be discussed in this paper.