White balance (WB) is a critical back-end processing function in image sensors to keep color constancy under various lighting conditions by adjusting the RGB color channel gain values. In this work, we proposed a novel gate-controlled gain-tuning method for a fully depleted silicon-on-insulator (FDSOI) one-transistor (1 T) pixel to achieve WB inside the sensor. Based on the pixel structure of a p-well under the buried oxide for sensing and an n-type nMOSFET on the top for readout, the 1 T pixel output gain is modulated by the MOSFET gate according to the transistor transfer characteristics. About 5x gain modulation range in RGB spectrum photoresponse (nonlinearity < 3%) is experimentally demonstrated in the devices fabricated by 22 nm FDSOI-based technology. The scheme for in-sensor WB demonstration is provided with a novel 1 T pixel array design, and the evaluation result shows in-sensor WB achieving an almost equivalent performance (Delta-E deviation < 1) compared with using conventional back-end WB.