<p>The treatment of wastewater plays a crucial role in protecting the environment and ensuring the sustainable use of resources. This research paper presents a new methodology for managing wastewater treatment operations, utilising Self-Organizing Fuzzy Sliding Mode Controller (SOFSMC) to enhance the efficiency of treatment procedures. MATLAB Simulink functions as a simulation tool that facilitates meticulous analysis. SOFSMC presents a control strategy that is both adaptive and robust. This strategy effectively regulates crucial parameters, including dissolved oxygen levels, pH levels, and flow rates. It achieves this within the challenging and complex framework of wastewater treatment, which is characterised by dynamic and nonlinear dynamics. Using a SOFSMC for wastewater treatment control is novel approach. This novel technique creates a self-learning, dynamic system using fuzzy logic (FL) and sliding mode control (SMC). This unique approach can autonomously adapt to wastewater treatment processes' complex and nonlinear dynamics, improving efficiency, resource optimisation, and system dependability. The results emphasise the potential of SOFSMC as a revolutionary approach for wastewater treatment. This approach can improve treatment effectiveness, conserve resources, and protect the environment. The proposed method SOFSMC, exhibits commendable outcomes, with an integrated absolute error of 0.082 mg/L, an integrated square differential error of 0.091 mg/L, and a response time of 1.85 seconds This study offers a substantial advancement in the field of wastewater treatment regulation, highlighting its significance in the context of sustainable water management and environmental conservation.</p>