This paper explores a pursuit–evasion game (PEG) based on quadrotors by combining fuzzy Q-learning (FQL) and model-predictive control (MPC) algorithms. Initially, the FQL algorithm is employed to perceive, make decisions, and predict the trajectory of the evader. Based on the position and velocity information of both players in the game, the pursuer quadrotor determines its action strategy using the FQL algorithm. Subsequently, a state feedback controller is designed using the MPC algorithm, with reference inputs derived from the FQL algorithm. Within each MPC cycle, the FQL algorithm dynamically provides reference inputs to the MPC, thereby enhancing its robust control and dynamic optimization for the quadrotor. Finally, simulation results verify the effectiveness of the proposed algorithm.