In this paper, an adaptive fuzzy disturbance observer (FDO)-based control is proposed for the swing suppression of the mooring-heavy lift crane (HLC)-cargo system in the presence of a wave disturbance. First, the dynamic model of the HLC system is determined by employing the Lagrangian method, and the wave force is modeled as an exosystem with unknown terms based on the Jonswap spectrum. Then, based on the HLC model and the wave force exosystem, an FDO is established to determine the wave disturbances, and a fuzzy approximator is developed to estimate the unknown terms. A novel disturbance estimation error observer is first developed to facilitate the parameter adaptive updating law. Subsequently, by augmenting the HLC system and disturbance estimation error system, an FDO-based fuzzy antiswing control method is proposed in terms of the linear matrix inequality technique to suppress the swing. The closed-loop system stability is examined by using the Lyapunov method. Finally, the effectiveness of the proposed method is validated by numerical simulation.