IntroductionPublic health emergencies can have a ripple effect on the resilience of multimodal transport network, which will lead to problems such as route disruptions or blockages, route selection change and information transmission delay spreading to the whole network, further hindering the transportation planning and operational efficiency of the network. MethodsThis study constructs a multimodal transport route optimization model under uncertainty with the objective of the sum of transportation cost, transshipment cost, penalty cost and carbon emission cost. To enhance the computational efficiency of the model, a novel invasive weed optimization with memory and encoding value clustering capabilities is proposed. In addition, by fusing the Q-learning algorithm in reinforcement learning with the novel invasive weed algorithm, the action-value function table obtained from the training facilitates the selection of optimal routes. Based on empirical data, explore the sensitivity analysis of node disruptions, time windows, and fuzzy demand on route decision-making under public health emergencies. ResultsThe transport network is affected by public health emergencies, which makes the optimal route deviate from the expected goal, resulting in an increase in the total cost. The proportion of total cost is determined by the position of nodes in the network, with critical nodes suffering more losses than ordinary nodes. Reasonable setting of time windows and fuzzy demand intervals is an effective way to improve the resilience and transportation efficiency of multimodal transport network. ConclusionsThis study provides more applicable decision-making references for enterprises to prevent the risk of supply chain disruptions caused by public health emergencies.